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In this review, we look into the in-vivo and in-vitro anticancer activity of Andrographolide and its derivatives. Through tailored drug development techniques that not only concentrate on conventional routes but also incorporate particular signaling pathways, Andrographolide's demonstrate their anticancer benefits.
Along with the suppression of the P13K/Akt pathway, which is linked to inflammation and activation the Nrf-2/HO-1 system, which is linked to antioxidant processes, these pathways include Wnt/-catenin, Hippo, Hedgehog,NF-B, STAT, p53 and P13-K/AKT/ERK. Through anti-arrhythmic, anti-hypertensive, anti-inflammatory and antioxidant mechanisms, animal studies have demonstrated that Andrographolide and its derivatives are effective against cancer. As a result, Andrographolide and its derivatives may prove to be excellent candidates for the creation of brand-new colorectal cancer treatment compounds. In the near future, more investigation and study in this area might result in viable therapy possibilities.
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