Formulation, Development, Evaluation and Comparative Study of Ketorolac Tromethamine Loaded Colloidal Gel
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Abstract
The aim of this study is formulation development of ketorolac tromethamine loaded colloidal gel, to evaluate pre-formulation and post-formulation parameters of gel with effect of different gelling agent and their comparative study. Initially, pre-formulation studies were done after that formulation of ketorolac tromethamine was prepared using solvent dispersion method, and then post formulation studies were done. The API used ketorolac tromethamine has excellent NSAIDs potency, which is used in formulation of gel. The gel will provide a better retention time at the site of application as well as site of drug absorption, so that the drug will get enough time for absorption. The formulation prepared will produce oral pain relief effect in case of dental problems. The various parameters studies in the formulation of gel includes: Organoleptic properties, viscosity study, in-vitro drug release study, FT-IR of API, and gelling agent. Formulation F4 provides better gelling strength to the gel with good retention\on time.
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References
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