Assessment of Hepatoprotective Potential of Ecbolium Linneanum Extract on Experimental Animals
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Abstract
The hepatoprotective potential of Ecbolium Linneanum extract was evaluated in experimental animals. Liver diseases pose a significant health burden worldwide, and the search for effective hepatoprotective agents is ongoing. In this study, we investigated the potential of Ecbolium Linneanum extract in protecting the liver against damage induced by various hepatotoxic agents.
Treatment with Ecbolium Linneanum extract resulted in a significant attenuation of liver damage induced by the hepatotoxic agents. Biochemical parameters such as serum levels of liver enzymes, bilirubin, and lipid peroxidation were restored to near-normal levels in the extract-treated groups compared to the control group. Histopathological examination of liver tissues further confirmed the protective effect of Ecbolium Linneanum extract, showing reduced hepatocellular necrosis, inflammation, and fatty infiltration. Furthermore, treatment with Ecbolium Linneanum extract improved liver function markers, including increased levels of antioxidant enzymes and enhanced hepatic glycogen content. The extract also exhibited significant anti-inflammatory activity, as evidenced by reduced levels of pro-inflammatory cytokines in the liver.
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References
Latha, U., Rajesh, M.G., Latha, M.S., 1999. Hepatoprotective effect of an ayurvedic medicine. Indian Drugs 36, 470–473.
2. Venkateswaran, S., Pari, L., Viswanathan, P., Menon, V.P., 1997. Protective effect of Livex, a herbal formulation against erythromycin estolate-induced hepatotoxicity in rats. Journal of Ethnopharmacology 57, 161–167.
Mitra, S.K., Seshadri, S.J., Venkataranganna, M.V., Gopumadhavan, S., Venkatesh Udupa, U., Sarma, D.N.K., 2000. Effect of HD-03-a herbal formulation in galactosamine-induced hepatopathy in rats. Indian Journal of Physiology and Pharmacology 44, 82–86.
Dhuley, J.N., Naik, S.R., 1997. Protective effect of Rhinax, a herbal formulation against CCl4-induced liver injury and survival in rats. Journal of Ethnopharmacology 56, 159–164.
Tathe P. R., Bheemachari., Uplanchiwar V., Modi A., Gahane A., Jain S. K., Jain R., 2010 Hepatoprotective Activity of Fruit Extract of Sesbania Grandiflora, Pers. Pharmacology online, 3: 423-430.
Venkatesh B., Uplanchiwar V., Gahane A., Telrandhe U. B., Modi A., 2010 Protective effect of L-35, A Herbal Formulation, against Isoniazid induced Hepatotoxicity in Rats. Journal of Pharmacy Research. 3(6).
Venkatesh B., Bheemachari., Uplanchiwar V., Modi A., Gahane A., Jain S. K., Tiwari S., 2010. Hepatoprotective Effect of L-35-A Polyherbal Formulation. Pharmacologyonline 3: 431-438.
Sharma B., Sharma U. K., 2009 Hepatoprotective activity of some indigenous plants. International Journal of PharmTech Research. Vol: 1(4), 1330-1334.
Ali E. A. S., Mousa H. N., Wajdi J. M., 2019 Medicinal plants possessed hepatoprotective activity. IOSR Journal of Pharmacy. Vol: 9(8), 26-56.
Guntupalli M M R, Chandana V R, Palpu P, Annie S. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol 2006; 103: 484–490.
Avijeet J, Manish S, Lokesh D, Anurekha J, Rout SP, Gupta VB, Krishna KL. Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. Leaves. J Ethnopharmacol 2007.
Mary C, Kasturi S, Parames CS. Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress. Pathophysiol 2006; 13: 95–102
Telrandhe U. B., Modi A., Uplanchiwar V., Gahane A., Hemalatha S., Goswami D.V., 2010. Hepatoprotective and Antioxidant activity of Root of Cadaba farinosa, Forsk. against Carbon Tetra Chloride induced Hepatotoxicity in Rats.Journal of Pharmacy Research 3(6).
Pornpen Pramyothin, Patcharavadee Samosorn, Somlak Poungshompoo, Chaiyo Chaichantipyuth. The protective effects of Phyllanthus emblica Linn. Extract on ethanol induced rat hepatic injury. J Ethnopharmacol 2006; 107:361–364.
Blancho CD, Gentil S. Alterations of glucose metabolism in chronic liver disease. Diab Res Clin Prac 8, 1990:29-36.
Deb AC. Fundamentals of biochemistry. 7th ed. New Central Book Agency: Kolkata,
Devhare, Lalchand D., and Niharika Gokhale. "Antioxidant and Antiulcer property of different solvent extracts of Cassia tora Linn." Research Journal of Pharmacy and Technology 15.3 (2022): 1109-1113
Devhare, Lalchand D., and Niharika Gokhale. "A brief review on: phytochemical and antiulcer properties of plants (fabaceae family) used by tribal people of gadchiroli maharashtra." International journal of pharmaceutical sciences and research 14.4 (2023): 1572-1593.
Devhare, Lalchand D., and Niharika Gokhale. "Acid Neutralizing Capacity and Antimicrobial Potential of Selected Solvent Extract From Various Indigenous Plants." Journal of Advanced Scientific Research 12.04 (2021): 175-179.
Makhani, A. A., and Lalchand Devhare. "Development and validation of vierordt's spectrophotometric method for simultaneous estimation of Drotaverine and Nimesulide combination." Research Chronicle in Health Sciences 3.2 (2017): 22-28.
Devhare, L. D., et al. "Method development for determination of water content from various materials by spectrophotometry and it’s validation." International journal of drug delivery 7.4 (2015): 233-240.
Devhare, Lalchand D., and Niharika Gokhale. "In silico anti-ulcerative activity evaluation of some bioactive compound from Cassia tora and Butea monosperma through moleculer docking approach." International journal of pharmaceutical sciences and research 14.2 (2023): 1000-08.
Devhare, Lalchand D., et al. "Important role of food and nutritional security during Covid-19: A survey." cancer 4 (2023): 5.
Bodhankar, Shishupal S., et al. "Formulation and in vitro evaluation of dental gel containing ethanglic extract of Mimosa pudica." European Chemical Bulletin 12 (2023): 1293-1299.
Makhani, A. A., and L. D. Devhare. "Development and Validation of Analytical Methods for Drotaverine and Nimesulide Combination." Research Chronicle in Health Sciences 3.3 (2017): 40-44.
Devhare, Lalchand, and P. K. Kore. "A recent review on bioavailability and solubility enhancement of poorly soluble drugs by physical and chemical modifications." Research Chronicle in Health Sciences 2.5 (2016): 299-308.
Ghugare, A. P., et al. "Development and validation of analytical methods for the simultaneous estimation of Nimorazole and Ofloxacin in tablet dosage form."
Tonde, T. U., R. H. Kasliwal, and L. D. Devhare. "Quantitative Estimation of Bacoside A in Polyherbal Memory Enhancer Syrup for Memory Boosting Activity Using HPTLC Method." Research Chronicle in Health Sciences 2.6 (2016): 315-320.
Shende, Shubham M., et al. "In-Vitro: Micropropagation of Mint and Investigate The Antibacterial Activity Of Mint Extract." Eur. Chem. Bull 12 (2023): 780-784.
Suruse, Pravin B., et al. "Rimegepant Embedded Fast Dissolving Films: A Novel Approach For Enhanced Migraine Relief." Journal of Survey in Fisheries Sciences (2023): 2071-2084.
Suruse, Pravin B., et al. "Exploring the potential of Aerva Lanata extract in a herbal ointment for fungal infection treatment." Journal of Survey in Fisheries Sciences (2023): 1922-1932.
Devhare, Lalchand, Sachin Hiradeve, and Trupti Bobade. Method Development & Validation For Determination Of Water Content. LAP LAMBERT Academic Publishing, 2017.
Singh, Shailja, et al. "An Update on Morphology, Mechanism, Lethality, And Management Of Dhatura Poisoning."
Pathak, Neha R., et al. "A Clinial Review on Pharmacological Evaluation of Thiazolidine and Isatin In The New Millenium As Magic Moieties."
Thakare, Vinod M., et al. "Separation and Purification of Carboxymethyl Cellulose From Spinacia Oleracea for Use In Pharmaceutical Dosage Form."
Mahesh Prasad, Abhishek Suman, Swati Srivastava, Lalchand D Devhare et al. Butea monosperma stem bark extract partially reverses high fat diet-induced obesity in rats. Eur. Chem. Bull. 2023, 12(Reg Issue 5), 4267 - 4273
Harshal. G. Salpe, L. D. Devhare, Anjali Ghugre, & Navjot Singh. Formulation and evaluation of hpmc coated diltiazem hcl tablet and its comparison with other marketed preparation. Research chronicle in health sciences. 2016, 3(1), 11-17