Pathophysiology and Management of Urinary Tract Infection in Type 2 Diabetes Mellitus – A Review.
Main Article Content
Abstract
In type 2 diabetes mellitus (T2DM) patients, Urinary Tract Infection (UTI) are a frequent complication with a greater incidence and recurrence rate than in the general population. UTIs in T2DM have a complicated pathophysiology that is caused by several variables, including hyperglycemia, diabetic neuropathy, and urinary stasis. Bacterial growth and pathogenicity are encouraged by hyperglycemia, which increase colonization and infection. Successful care of UTIs in people with T2DM necessitates an all-encompassing strategy that tackles the infection as well as underlying causes that led to its occurrence. Even though choosing the right antibiotic based on bacterial culture and sensitivity tests is crucial in people with T2DM due to a higher risk of antibiotic resistant bacteria, antibiotics are the main treatment for UTIs. To avoid potentially fatal consequences including pyelonephritis and sepsis, early detection, and timely treatment of UTIs in people with are crucial. Effective treatment of UTIs in people with T2DM necessities a multidisciplinary strategy that condition’s complicated pathophysiology and associated consequence. Healthcare professionals can lessen the prevalence of UTIs in people with T2DM and enhance their general health outcomes and quality of life by implementing a comprehensive management plan that tackles both the infection and the underlying causes that lead to its development.
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References
Geerlings SE, Hoepelman AIM. Immune dysfunction in patients with diabetes mellitus (DM). F1000Research. 2017; 6:1–11. doi: 10.12688/f1000research.10525.1
Meiland R, Geerlings SE. Diagnosis and management of urinary tract infection and pyelonephritis in the older adult. Clin Geriatr Med. 2016;32(3):523–38. doi: 10.1016/j.cger.2016.02.005
Schäffer AJ, Matsumoto T, Saito M, Kumon H. When a urinary tract infection is not a urinary tract infection: Clinical implications of a confusing case. Can Urol Assoc J. 2011;5(5):E145–E147. doi: 10.5489/cuaj.10104
Zhang H, Chen Y, Wu J, et al. Risk factors for urinary tract infection in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. BMJ Open Diabetes Res Care. 2020;8(1):e001567. doi: 10.1136/bmjdrc-2020-001567
Lin WH, Wang YC, Wang YH, et al. Urinary tract infections in patients with diabetic kidney disease: Risk factors and biomarkers. J Hosp Infect. 2020;104(2):214-220. doi: 10.1016/j.jhin.2019.08.006
Kwak BO, Lee HS, Han DH. Risk factors for urinary tract infection in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Diabet Med. 2019;36(8):1045–54. doi: 10.1111/dme.13979
Li X, Xu H, Chen H, et al. The pathogenesis, management and prevention of urinary tract infections in patients with diabetes mellitus. Expert Rev Anti Infect Ther.2019;17(5):351-360.
Vaidya A, Jain R, Rajput R, et al. Urinary tract infections and diabetes mellitus: A review. J Lab Physicians. 2015;7(2):79-83,
Nicolle LE. Urinary tract infections in patients with diabetes mellitus. Semin Nephrol. 1999;19(4):327-341.
Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Am J Med. 2002 Jul 8;113 Suppl 1A:14S-19S.
Nicolle LE. "Urinary tract infections in diabetes. Epidemiology, pathogenesis and treatment." Diabetes Metab Res Rev. 2001 Mar-Apr;17(2): 10.1002/dmrr.195
Zhanel GG, Harding GK, Nicolle LE. "Asymptomatic bacteriuria in patients with diabetes mellitus." Rev Infect Dis. 1991 Sep-Oct;13(5):797-802. doi: 10.1093/clinids/13.5.797.
Jhung YJ, Chen HC, Chen HS, Tsai CC, Lin BS, Huang YC, Chen JW. "Urinary tract infection in diabetic patients: risk factors, clinical features, and outcomes." Medicine (Baltimore).
Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015;13(5):269-284.
Al-Badr A, Al-Shaikh G. Recurrent urinary tract infections management in women: A review. Sultan Qaboos Univ Med J. 2013;13(3):359-367
Sethia, U. Assessment of the Urinary Tract Infection (UTI) in Patients Suffered from Diabetes.
Lopes, A. C., Lourenço, O., Roque, F., & Morgado, M. (2023). Clinical and Pharmacotherapeutic Profile of Patients with Type 2 Diabetes Mellitus Admitted to a Hospital Emergency Department. Biomedicines, 11(2), 256.
Foxman B. The epidemiology of urinary tract infection. Nat Rev Urol. 2010;7(12):653-660.
Blango MG, Mulvey MA. Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. Antimicrob Agents Chemother. 2010;54(5):1855-1863.
Lim JH, Kim JH, Kim JS, et al. Factors associated with the recurrence of urinary tract infections in Korean women. Korean J Urol. 2010;51(7):492-496.
Schneeberger C, Geerlings SE, Middleton P, et al. Predictors of urinary tract infection in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. 2017;40(10):1385-1394.
Zhanel GG, Nicolle LE, Harding GK. Prevalence of asymptomatic bacteriuria and associated host factors in women with diabetes mellitus. The Manitoba Diabetic Urinary Infection Study Group. Clin Infect Dis. 1995;21(2):316-322.