A Review on Sustained Release Drug Delivery and Sustained Release Matrix Tablets

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Published: May 29, 2023
Keywords:
Sustained release Controlled release Matrix tablet SRDDS Half-life Bioavailability

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Vishwas C. Bhagat
Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Tal. Bhor Dist. Pune 412206 (Maharashtra), India.
Pravin B. Awate
Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Tal. Bhor Dist. Pune 412206 (Maharashtra), India.
Deepak P. Kardile
Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Tal. Bhor Dist. Pune 412206 (Maharashtra), India.
Onkar P. Pawar
Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Tal. Bhor Dist. Pune 412206 (Maharashtra), India.
Rajkumar V. Shete
Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Tal. Bhor Dist. Pune 412206 (Maharashtra), India.
Amit D. Bichukale
Department of Pharmaceutics, Satara College of Pharmacy, Satara 415001(Maharashtra), India.
Jayesh M. Raut
Department of Pharmaceutics, Satara College of Pharmacy, Satara 415001(Maharashtra), India.
Sukanya R. Mane
Department of Quality Assurance Techniques, Satara College of Pharmacy, Satara 415001(Maharashtra), India.

Abstract

Oral medication delivery is still the finest and most popular method for administering pharmaceuticals via the internal route. A Sustained Release is also a good option for reducing a drug's negative effects and boosting its therapeutic potency. The fundamental ideas of sustained drug delivery systems optimize a variety of factors, including a medication's biopharmaceutical, pharmacokinetic and Pharmacodynamic properties, such that therapeutic efficacy is increased, side effects are minimized, and disease treatment is made simple. The major methods of manufacturing sustained-release matrix tablets include wet granulation, direct compression, or dispersion of solid particles within solid particles within a porous matrix created by employing various polymers. The matrices employed might be mineral, hydrophilic, hydrophobic, or biodegradable in nature. Therefore, by lowering the overall dosage and dosing schedule, sustained-release matrix tablets may improve patient compliance, which is very beneficial for treating chronic diseases. Studies of in-vitro dissolution can be used to determine the medication release rate. The main objective of this study is to provide comprehensive information for sustained release matrix tablet dosage form.

Article Details

How to Cite
Vishwas C. Bhagat, Pravin B. Awate, Deepak P. Kardile, Onkar P. Pawar, Rajkumar V. Shete, Amit D. Bichukale, Jayesh M. Raut, & Sukanya R. Mane. (2023). A Review on Sustained Release Drug Delivery and Sustained Release Matrix Tablets. Journal of Coastal Life Medicine, 11(2), 1174–1190. Retrieved from https://www.jclmm.com/index.php/journal/article/view/1142
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Vol. 11: Number 2, 2023
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Articles

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