The High Potential Prognostic Factors for Oral Squamous Cell Carcinoma (OSCC): A Neural Network (RBF) and Principle Components Analysis (PCA) Plot Approach

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Wan Muhamad Amir W Ahmad
Muhammad Azeem Yaqoob
Mohamad Nasarudin Adnan
Farah Muna Mohamad Ghazali
Nor Farid Mohd Noor
Nor Azlida Aleng
Nurfadhlina Abdul Halim
Nuzlinda Abdul Rahman
Noor Maizura Mohamad Noor


The aim of this research paper is to discuss the basic idea of the methodology building of the prognostic model for Oral Squamous Cell Carcinoma (OSCC) through the Radial Basis Function (RBF) model and Principle Component Analysis (PCA). This combined methodology is our main focus for the OSCC factor determination. Results from the RBF model will be verifying through PCA for validation purposes. Through the PCA plots, special characteristics or patterns of the tumor size will be assessed. The gained pattern will be studied for the characteristic association. This combined technique had led to successful research, giving the best results for decision making especially among the decision-maker and provide very important information for health science education. The utmost finding from this study, it provides a very useful information about the tumor size and their association and also gives an idea for further active treatment.

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Wan Muhamad Amir W Ahmad, Muhammad Azeem Yaqoob, Mohamad Nasarudin Adnan, Farah Muna Mohamad Ghazali, Nor Farid Mohd Noor, Nor Azlida Aleng, Nurfadhlina Abdul Halim, Nuzlinda Abdul Rahman, & Noor Maizura Mohamad Noor. (2023). The High Potential Prognostic Factors for Oral Squamous Cell Carcinoma (OSCC): A Neural Network (RBF) and Principle Components Analysis (PCA) Plot Approach. Journal of Coastal Life Medicine, 11(2), 1191–1197. Retrieved from


Ajila V, Shetty H, Babu S, Shetty V, Hegde S. Human Papilloma Virus Associated Squamous Cell Carcinoma of the Head and Neck. J Sex Transm Dis, 2015.

Almangush A, Coletta RD, Bello IO. A Simple Novel Prognostic Model for Early Stage Oral Tongue Cancer. Int J Oral Maxillofac Surg, 2015.

Brandwein-Gensler M, Teixeira MS, Lewis CM. Oral Squamous Cell Carcinoma: Histologic Risk Assessment, but Not Margin Status, is Strongly Predictive of Local Disease-Free and Overall Survival. The American Journal of Surgical Pathology, 2005.

Dissanayaka WL, Pitiyage G, Kumarasiri PVR, Liyanage RLPR, Dias KD, Tilakaratne WM. Clinical and Histopathologic Parameters in Survival of Oral Squamous Cell Carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2012.

Ferlay J, Soerjomataram I, Dikshit R. Cancer Incidence and Mortality Worldwide: Sources, Methods and Major Patterns in GLOBOCAN 2012. Int J Cancer, 2015

Gillison ML, Koch WM, Capone RB. Evidence for A Causal Association Between Human Papillomavirus and A Subset of Head and Neck Cancers. Journal of The National Cancer Institute, 2000.

Mehrotra R, Yadav S. Oral Squamous Cell Carcinoma: Etiology, Pathogenesis and Prognostic Value of Genomic Alterations. Indian J Cancer, 2006.

W.M.A.W. Ahmad., M.A. Yaqoob, Nurfadhlina Abd Halim, N.A. Aleng, Z. Ali and R.Hassan. Computer Programming Based: An Optimized Prognostic Model of The Fuzzy Survival Oral Cancer Using Sas. Journal of Science and Arts, 2018.

W.M.A.W. Ahmad, M.S. Ibrahim, R. A. Rohim, Z. Ali. Predicting The Predictor's Variables of Survival Time for Oral Cancer With Decision Tree Analysis. International Journal of Advanced and Applied Sciences, 2018.

W.M.A.W. Ahmad, N.A. Aleng, Z. Ali, M. S. M. Ibrahim. Statistical Modeling via Bootstrapping and Weighted Techniques Based on Variances. Engineering, Technology & Applied Science Research, 2018.

W.M.A.W. Ahmad, N. A. Aleng, Y. Dasril, N.A Halim, R. Hasan, Z. Ali, A.Baharum & S.Zakaria. International Journal of Multidisciplinary Research and Modern Education (IJMRME), 2017.

W. M. A. W. Ahmad, R. A. A. Rohim, Y. Norhayati, N. A. Aleng Z. Ali. Developing A New Dimension of an Applied Exponential Model: Application in Biological Sciences. Engineering, Technology & Applied Science Research, 2018.

Yaaqob MA, Hairon SM, Kannan TP, Rahman NA. Factors Associated with Mortality of Oral Squamous Cell Carcinoma (OSCC) Patients Managed at Hospital USM. Archives of Orofacial Science, 2019.

L. Khaled and V.Roa Vemuri. An Application of Principal Component Analysis to The Detection and Visualization of Computer Network Attacks. Annales Des Telecommunications, 2006.

Vargas-Ferreira F, Nedel F, Etges A, Gomes APN, Furuse C, Tarquinio SBC. Etiologic Factors Associated with Oral Squamous Cell Carcinoma in Non-Smokers and Non-Alcoholic Drinkers: A Brief Approach. Brazilian Dental Journal, 2012.