A Review Article – Pyrimidines as a Propitious Scaffold for Numerous Bioactive Compounds
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Abstract
In recent years, the resistance of organisms toward drugs has accelerated at an alarming rate. Hence, the search for newer drugs is incessant. Pyrimidines, six-membered heterocyclic compounds, form the basis of our DNA and RNA. This pharmacophore possesses an extensive array of biological activities, namely antimicrobial, anti-cancer, anticonvulsant, anthelmintic, etc. This review aims at describing recent reports in the field of pyrimidine synthesis along with the pyrimidine-based drugs employed to treat numerous disorders. A detailed summary of the pyrimidine moiety, including its structure, various reactions it undergoes, numerous substituted and fused pyrimidines, along with their biological significance, etc., has been reported. This panoramic study has been undertaken to facilitate a scaffold for discovering newer drugs.
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References
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