Development and Characterization of Some Novel Herbal Composition for Treating Diabetes Using Fenugreek and Cinnamon Extracts

Main Article Content

Mohd Ruman Khan
Kajal Khan
Pankaj Mohan Pimpalshende
Sachin Tyagi
Sayyed Mateen
Sakshi Aole
Gourishankar Birtia


Clinical exploration recommends that successive utilization of utilitarian food sources can assist with staying away from T2DM and its ramifications. This minimal expense technique for treating T2DM in emerging countries could be extremely useful. To look at the advantages of fenugreek and cinnamon on the treatment of recently analyzed instances of T2 DM, a randomized controlled try was directed. The India Organization of Clinical Sciences Medical clinic in Islamabad filled in as the wellspring of the subjects. Three periods of the review were directed: Stage I, gauge; Stage II, following 90 days; and Stage III, at the finish of the waste of time period. Times of the subjects, who were of the two genders, went from 40 to 65. 26 subjects made up each gathering. At benchmark, the finish of the second and third stages, and fasting insulin levels and lipid profiles were undeniably surveyed in the serum. All periods of the concentrate additionally included assessment of BMI, WC, and WHR. For the examination, SPSS (adaptation 22) was used. Around 60% of individuals use customary meds that are produced using medicinal plants.

Article Details

How to Cite
Mohd Ruman Khan, Kajal Khan, Pankaj Mohan Pimpalshende, Sachin Tyagi, Sayyed Mateen, P.Balaji, Sakshi Aole, & Gourishankar Birtia. (2023). Development and Characterization of Some Novel Herbal Composition for Treating Diabetes Using Fenugreek and Cinnamon Extracts. Journal of Coastal Life Medicine, 11(2), 1246–1254. Retrieved from


Anand, P.; Murali, K.Y.; Tandon, V.; Murthy, P.S.; Chandra, R. Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats. Chem. Biol. Interact. 2010, 186, 72–81.

Chatterjee, S.; Khunti, K.; Davies, M.J. Type 2 diabetes. Lancet 2017, 389, 2239–2251.

Chaturvedi, R.; Desai, C.; Patel, P.; Shah, A.; Dikshit, R.K. An evaluation of the impact of antidiabetic medication on treatment satisfaction and quality of life in patients of diabetes mellitus. Perspect. Clin. Res. 2018, 9, 15–22.

ElSayed, N.A.; Aleppo, G.; Aroda, V.R.; Bannuru, R.R.; Brown, F.M.; Bruemmer, D.; Collins, B.S.; Cusi, K.; Das, S.R.; Gibbons, C.H.; et al. Introduction and methodology: Standards of care in diabetes-2023. Diabetes Care 2023, 46, S1–S4.

Gale, E.A. Collateral damage: The conundrum of drug safety. Diabetologia 2009, 52, 1975–1982.

Hannan, J.M.; Ali, L.; Rokeya, B.; Khaleque, J.; Akhter, M.; Flatt, P.R.; Abdel-Wahab, Y.H. Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. Br. J. Nutr. 2007, 97, 514–521.

Khan, A.; Safdar, M.; Ali Khan, M.M.; Khattak, K.N.; Anderson, R.A. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003, 26, 3215–3218.

Patel, D.K.; Kumarm, R.; Laloo, D.; Hemalatha, S. Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects. Asian Pac. J. Trop. Dis. 2012, 2, 239–250.

Petersmann, A.; Müller-Wieland, D.; Müller, U.A.; Landgraf, R.; Nauck, M.; Freckmann, G.; Heinemann, L.; Schleicher, E. Definition, classification and diagnosis of diabetes mellitus. Exp. Clin. Endocrinol. Diabetes 2019, 127, S1–S7.

Rafraf, M.; Malekiyan, M.; Asghari-Jafarabadi, M.; Aliasgarzadeh, A. Effect of Fenugreek Seeds on Serum Metabolic Factors and Adiponectin Levels in Type 2 Diabetic Patients. Int. J. Vitam. Nutr. Res. 2014, 84, 196–205.

Ranade, M.; Mudgalkar, N. A simple dietary addition of fenugreek seed leads to the reduction in blood glucose levels: A parallel group, randomized single-blind trial. Ayu 2017, 38, 24–27.

Tran, N.; Pham, B.; Le, L. Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery. Biology 2020, 9, 252.

Verma, N.; Usman, K.; Patel, N.; Jain, A.; Dhakre, S.; Swaroop, A.; Bagchi, M.; Kumar, P.; Preuss, H.G.; Bagchi, D. A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes. Food Nutr. Res. 2016, 60, 32382.

Xue, W.L.; Li, X.S.; Zhang, J.; Liu, Y.H.; Wang, Z.L.; Zhang, R.J. Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Asian Pac. J. Clin. Nutr. 2007, 16, 422–426.

Yaghmoor, S.S.; Khoja, S.M. Effect of cinnamon on plasma glucose concentration and the regulation of 6-phosphofructo-1-kinase activity from the liver and small intestine of streptozotocin induced diabetic rats. J. Biol. Sci. 2010, 10, 761–766.