Exploring the Influence of an Antifungal Medication on Patients Receiving Oral Hypoglycemic Therapy: Investigating the Interplay Between Medications
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Abstract
In situations where diabetic patients who are prescribed either pioglitazone or repaglinide may also require treatment with an antifungal medication such as Itraconazole. In order to explore the potential interactions between Itraconazole and oral anti-diabetic agents, this study was carried out. Whole study was divided in 3 phases and blood glucose level (BGL) was measured. In the study, it was found that there are changes in BGL in normal and diabetic animals when concurrently used with itraconazole which may be due to at metabolic stage. The observed potentiation of hypoglycemic effects of both pioglitazone and repaglinide by itraconazole pre-treatment can be attributed to pharmacokinetic modification by Itraconazole.
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References
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