In Vitro Antioxidant Activity of Aqueous Extract of Saffron and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin-Induced Diabetic Female Rats

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Sonu Sharma
Nitin B Ghiware
Neelmani Chauhan
Jyoti Gorakh Wagh
Vineeta Khanvilkar
Kavita Yogesh Pawar
Sadiqul Alam
Rajesh E Jesudasan


In this work, the substance of hepatic non-enzymatic antioxidants in STZ-diabetic rats was analyzed according to the impacts of an aqueous saffron extract and vigorous activity. Utilizing a randomization interaction, 41 male rats (age: 12 weeks; weight: 31426.7 gr) were isolated into five gatherings: solid control (HC; n = 6); diabetic-control; diabetic-vigorous preparation; diabetic-saffron; and diabetic-high-impact preparing saffron (DATS; n = 5). The DS and DATS bunches ran on the treadmill for a long time, five straight meetings, at a speed of 12 m/min and a slant of 0% for 30 min. They likewise consumed 25 mg/kg of saffron aqueous extract every day for a long time. The rats were made it lights-out time prior to being killed. The livers were then taken out to gauge the degrees of malondialdehyde (MDA), glutathione (GSH), and generally speaking antioxidant limit. The DATS and DC groups, respectively, saw the greatest and smallest increases in TAC concentration (P=0.006). It would seem that using saffron extract in conjunction with aerobic exercise would be a suitable strategy for boosting the hepatic non-enzymatic antioxidant system in diabetic rats.

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Sonu Sharma, Nitin B Ghiware, Neelmani Chauhan, Jyoti Gorakh Wagh, Vineeta Khanvilkar, Kavita Yogesh Pawar, Sadiqul Alam, & Rajesh E Jesudasan. (2023). In Vitro Antioxidant Activity of Aqueous Extract of Saffron and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin-Induced Diabetic Female Rats. Journal of Coastal Life Medicine, 11(2), 1263–1270. Retrieved from


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