Correlation of Vitamin B12 with Homocysteine Levels in Cerebral Venous Sinus Thrombosis

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Sahith Reddy Gantla
Ninad Mallana Mulimani
Mallana Mulimani


Introduction: In geriatric individuals,Stroke is the third most frequent cause of disability. A stroke is caused by cerebral venous sinus thrombosis between 0.5 and 3.0% of the time, primarily younger people are affected and has an incidence of three–four adults per million. Previous studies have stated that Hyper-Homocystenemia is associated with venous thromboembolism and atherosclerotic arterial disease, but the relationship between vitamin B12 deficiency, Hype-Homocystenemia and Cerebral venous thrombosis remains debatable. Thus the present study was undertaken to estimate and correlate the serum level of Vitamin B 12 and homocysteine in cerebral venous sinus thrombosis (CVST) patients.

AIM & Objectives :To estimate and correlate Vitamin B12 with Homocysteine levels in cerebral venous thrombosis

Materials and methods: From January 2021 to July 2022, we conducted a hospital-based prospective observational study with a sample size of 55 patients who were admitted to BLDE (DU)'s B.M. Patil Medical College and Hospital, Vijayapura, with a clinical history and neurological examination correlating with cerebral venous thrombosis and radiological evidence. We excluded Patients who are on Drugs causing vitamin B12 deficiency, on drugs or with health conditions interfering with homocysteine metabolism and who are on vitamin B 12 supplementation. Detailed clinical history was taken and complete neurological examination was done for every subject included in the study. Fasting serum homocysteine and B12 levels were measured in all subjects. Using SPSS software, version 25, a descriptive analysis of each variable included in the study was carried out. Statistical significance was defined as P values of 0.05 or less.

Results:The proportion of vitamin B12 among various homocysteine levels varied statistically significantly with p value of <0.001. Maximum vitamin B12 deficient patients were observed in mild to moderate levels of Homocysteine. Homocysteine level and other parameters like GCS score, Prothrombin Time, Platelets counts and Hb level were not statistically correlated but Homocysteine level and Vitamin B12 level was significant negatively correlated at 10% level of significance.

Conclusion:Serum homocysteine level has significant negative correlation with vitamin B12 levels in patients with cerebral venous sinus thrombosis.

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Sahith Reddy Gantla, Ninad Mallana Mulimani, & Mallana Mulimani. (2023). Correlation of Vitamin B12 with Homocysteine Levels in Cerebral Venous Sinus Thrombosis. Journal of Coastal Life Medicine, 11(2), 1448–1455. Retrieved from


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