Traditional Uses of Cichorium Intybus and its Medicinal Importance for Health
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Abstract
Increasingly, it is acknowledged that fibers are essential to our diet and to maintaining health. Notably, it has been discovered that complex fibre mixes boost metabolic health. The bitter tree (Cichorium intybus L.) tuber, which contains almost 90% of its dry weight in fibre, is one of the vegetables with the highest level of fibre, according to our analysis of the fibres of tree products. In addition to unique phytonutrients like sesquiterpene lactones, which have a long history of research, chicory roots also contain lactose, pectin, and (hemi-) cellulose. The majority of the times, chicory root are now used as a raw materials to obtain inulin, a prebiotic fibre or dietary component. However, chicory roots have indeed been eaten like a vegetable by living in the past. The entire root has been used for nutritional, medicinal, as well as other purposes for millennia, and it is currently used in traditional dishes throughout the world. Here, we summaries the chemical structure of chicory roots in order to explain its longstanding popularity in human diets. We revisit the consumption of clover roots by people and detail the numerous types of use as well as their various preparation techniques. This paper focuses on the complete root in its intricate, organic state, as well as its contents, and discusses legislative regulations and also the health of chicory root preparations for personal food. Finally, we go over the current and future uses of chicory roots in relation to their dedication to a diet high in fibre. The six species of a Asteraceae genus Cichorium are predominantly found in Europe and Asia. It is frequently utilised in the field of medicine for the purpose of treating a wide variety of condition, ranging from wounds to diabetes. The chicory plant, also known as Cichorium intybus, is a popular substitute for coffee and goes by the name chicory. No one has looked into how the majority of this plant's component might have therapeutic uses, despite the fact that it has a long history of folkloric use. Currently, toxicological information on C. intended to govern is scarce. This article examines the economically and culturally significant medical use of C. intybus. In depth discussion of traditional applications, scientific validity, and phytochemical composition.
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References
Bais, H. P., & Ravishankar, G. A. (2001). Cichorium intybus L–cultivation, processing, utility, value addition and biotechnology, with an emphasis on current status and future prospects. Journal of the Science of Food and Agriculture, 81(5), 467-484.
van Arkel, J., Vergauwen, R., Sévenier, R., Hakkert, J. C., van Laere, A., Bouwmeester, H. J., ... & van der Meer, I. M. (2012). Sink filling, inulin metabolizing enzymes and carbohydrate status in field grown chicory (Cichorium intybus L.). Journal of Plant Physiology, 169(15), 1520-1529.
Van Wyk, B. E., Oudtshoorn, B. V., & Gericke, N. (1997). Medicinal Plants of South Africa. Briza.
Judžentienė, A., & Būdienė, J. (2008). Volatile constituents from aerial parts and roots of Cichorium intybus L.(chicory) grown in Lithuania. Chemija, 19(2).
Kroes, B., & Cimino, G. (2010). Assessment report on Cichorium intybus L., radix. European Medicines Agency (EMA), 113041.
Cadalen, T., Mörchen, M., Blassiau, C., Clabaut, A., Scheer, I., Hilbert, J. L., ... & Quillet, M. C. (2010). Development of SSR markers and construction of a consensus genetic map for chicory (Cichorium intybus L.). Molecular Breeding, 25(4), 699-722.
Gurib-Fakim, A. (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular aspects of Medicine, 27(1), 1-93.
Wang, Q., & Cui, J. (2011). Perspectives and utilization technologies of chicory (Cichorium intybus L.): A review. African Journal of Biotechnology, 10(11), 1966-1977.
E. Sezik, E. Yeşilada, G. Honda, Y. Takaishi, Y. Takeda, and T. Tanaka,2001 “Traditional medicine in Turkey X. Folk medicine in Central Anatolia,” Journal of Ethnopharmacology, vol. 75, no. 2-3, pp. 95–115, 2001.View at: Publisher Site | Google Scholar
T. A. Bischoff, C. J. Kelley, Y. Karchesy, M. Laurantos, P. Nguyen-Dinh, and A. G. Arefi,2004 “Antimalarial activity of Lactucin and Lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.,” Journal of Ethnopharmacology, vol. 95, no. 2-3, pp. 455–457, 2004.View at: Publisher Site | Google Scholar
E. Hanlidou, R. Karousou, V. Kleftoyanni, and S. Kokkini, “The herbal market of Thessaloniki (N Greece) and its relation to the ethnobotanical tradition,” Journal of Ethnopharmacology, vol. 91, no. 2-3, pp. 281–299, 2004.View at: Publisher Site | Google Scholar
B. Šarić-Kundalić, C. Dobeš, V. Klatte-Asselmeyer, and J. Saukel, “Ethnobotanical survey of traditionally used plants in human therapy of east, north and north-east Bosnia and Herzegovina,” Journal of Ethnopharmacology, vol. 133, no. 3, pp. 1051–1076, 2011.View at: Publisher Site | Google Scholar
M. L. Leporatti and S. Ivancheva, “Preliminary comparative analysis of medicinal plants used in the traditional medicine of Bulgaria and Italy,” Journal of Ethnopharmacology, vol. 87, no. 2-3, pp. 123–142, 2003.View at: Publisher Site | Google Scholar
P. N. Pushparaj, H. K. Low, J. Manikandan, B. K. H. Tan, and C. H. Tan, “Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats,” Journal of Ethnopharmacology, vol. 111, no. 2, pp. 430–434, 2007.View at: Publisher Site | Google Scholar
B. Ahmed, T. A. Al-Howiriny, and A. B. Siddiqui, “Antihepatotoxic activity of seeds of Cichorium intybus,” Journal of Ethnopharmacology, vol. 87, no. 2-3, pp. 237–240, 2003.View at: Publisher Site | Google Scholar
E. Miraldi, S. Ferri, and V. Mostaghimi, “Botanical drugs and preparations in the traditional medicine of West Azerbaijan (Iran),” Journal of Ethnopharmacology, vol. 75, no. 2-3, pp. 77–87, 2001.View at: Publisher Site | Google Scholar
P. M. Guarrera, G. Forti, and S. Marignoli, “Ethnobotanical and ethnomedicinal uses of plants in the district of Acquapendente (Latium, Central Italy),” Journal of Ethnopharmacology, vol. 96, no. 3, pp. 429–444, 2005.View at: Publisher Site | Google Scholar
M. C. Loi, L. Maxia, and A. Maxia, “Ethnobotanical comparison between the villages of Escolca and Lotzorai (Sardinia, Italy),” Journal of Herbs, Spices & Medicinal Plants, vol. 11, no. 3, pp. 67–84, 2005.View at: Publisher Site | Google Scholar
A. Pieroni, “Medicinal plants and food medicines in the folk traditions of the upper Lucca Province, Italy,” Journal of Ethnopharmacology, vol. 70, no. 3, pp. 235–273, 2000.View at: Publisher Site | Google Scholar
A. Pieroni, C. Quave, S. Nebel, and M. Heinrich, “Ethnopharmacy of the ethnic Albanians (Arbëreshë) of northern Basilicata, Italy,” Fitoterapia, vol. 73, no. 3, pp. 217–241, 2002.View at: Publisher Site | Google Scholar
H. Jouad, M. Haloui, H. Rhiouani, J. El Hilaly, and M. Eddouks, “Ethnobotanical survey of medicinal plants used for the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez-Boulemane),” Journal of Ethnopharmacology, vol. 77, no. 2-3, pp. 175–182, 2001.View at: Publisher Site | Google Scholar
J. El-Hilaly, M. Hmammouchi, and B. Lyoussi, “Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco),” Journal of Ethnopharmacology, vol. 86, no. 2-3, pp. 149–158, 2003.View at: Publisher Site | Google Scholar
M. Ahmad, R. Qureshi, M. Arshad, M. A. Khan, and M. Zafar, “Traditional herbal remedies used for the treatment of diabetes from district attock (Pakistan),” Pakistan Journal of Botany, vol. 41, no. 6, pp. 2777–2782, 2009.View at: Google Scholar
European Medicines Agency, “Assessment report on Cichorium intybus L., radix,” EMA/HMPC/113041/2010, 2013.View at: Google Scholar
K. Šavikin, G. Zdunića, N. Menković et al., “Ethnobotanical study on traditional use of medicinal plants in South-Western Serbia, Zlatibor district,” Journal of Ethnopharmacology, vol. 146, no. 3, pp. 803–810, 2013.View at: Publisher Site | Google Scholar
K. Monde, T. Oya, A. Shirata, and M. Takasugi, “A guaianolide phytoalexin, cichoralexin, from Cichorium intybus,” Phytochemistry, vol. 29, no. 11, pp. 3449–3451, 1990.View at: Google Scholar
101L. Kokoska, Z. Polesny, V. Rada, A. Nepovim, and T. Vanek, “Screening of some Siberian medicinal plants for antimicrobial activity,” Journal of Ethnopharmacology, vol. 82, no. 1, pp. 51–53, 2002.View at: Publisher Site | Google Scholar
C. L. Marley, R. Cook, R. Keatinge, J. Barrett, and N. H. Lampkin, “The effect of birdsfoot trefoil (Lotus corniculatus) and chicory (Cichorium intybus) on parasite intensities and performance of lambs naturally infected with helminth parasites,” Veterinary Parasitology, vol. 112, no. 1-2, pp. 147–155, 2003.View at: Publisher Site | Google Scholar
I. Süntar, E. K. Akkola, H. Kelesb, E. Yesiladac, S. D. Sarkerd, and T. Baykala, “Comparative evaluation of traditional prescriptions from Cichorium intybus L. for wound healing: stepwise isolation of an active component by in vivo bioassay and its mode of activity,” Journal of Ethnopharmacology, vol. 143, no. 1, pp. 299–309, 2012.View at: Publisher Site | Google Scholar
E. Sezik, E. Yeşilada, G. Honda, Y. Takaishi, Y. Takeda, and T. Tanaka, “Traditional medicine in Turkey X. Folk medicine in Central Anatolia,” Journal of Ethnopharmacology, vol. 75, no. 2-3, pp. 95–115, 2001.View at: Publisher Site | Google Scholar
F. Tetik, S. Civelek, and U. Cakilcioglu, “Traditional uses of some medicinal plants in Malatya (Turkey),” Journal of Ethnopharmacology, vol. 146, no. 1, pp. 331–346, 2013.View at: Google Scholar
A. Judžentienė and J. Būdienė, “Volatile constituents from aerial parts and roots of Cichorium intybus L. (chicory) grown in Lithuania,” Chemija, vol. 19, pp. 25–28, 2008.View at: Google Scholar
A. Pieroni, “Medicinal plants and food medicines in the folk traditions of the upper Lucca Province, Italy,” Journal of Ethnopharmacology, vol. 70, no. 3, pp. 235–273, 2000.View at: Publisher Site | Google Scholar
S. Jarić, Z. Popović, M. Mačukanović-Jocić et al., “An ethnobotanical study on the usage of wild medicinal herbs from Kopaonik Mountain (Central Serbia),” Journal of Ethnopharmacology, vol. 111, no. 1, pp. 160–175, 2007.View at: Publisher Site | Google Scholar
E. Leclercq, “Determination of lactucin in roots of chicory (Cichorium intybus L.) by high-performance liquid chromatography,” Journal of Chromatography A, vol. 283, pp. 441–444, 1984.View at: Google Scholar
W. Kisiel and K. Zielińska, “Guaianolides from Cichorium intybus and structure revision of Cichorium sesquiterpene lactones,” Phytochemistry, vol. 57, no. 4, pp. 523–527, 2001.View at: Publisher Site | Google Scholar
J. S. Pyrek, “Sesquiterpene lactones of Cichorium intybus and Leontodon autumnalis,” Phytochemistry, vol. 24, no. 1, pp. 186–188, 1985.View at: Google Scholar
P. Bridle, R. S. Thomas Loeffler, C. F. Timberlake, and R. Self, “Cyanidin 3-malonylglucoside in Cichorium intybus,” Phytochemistry, vol. 23, no. 12, pp. 2968–2969, 1984.View at: Google Scholar
E. O. Krebsky, J. M. C. Geuns, and M. de Proft, “Polyamines and sterois in Cichorium heads,” Phytochemistry, vol. 50, no. 4, pp. 549–553, 1999.View at: Publisher Site | Google Scholar
J. Malarz, A. Stojakowskaa, E. Sznelerb, and W. Kisiel, “A new neolignan glucoside from hairy roots of Cichorium intybus,” Phytochemistry Letters, vol. 6, pp. 59–61, 2013.View at: Publisher Site | Google Scholar
F. M. Hardeep and D. K. Pandey, “Anti-diabetic activity of methanolic extract of chicory roots in streptozocin induced diabetic rats,” International Journal of Pharmacy, vol. 3, no. 1, pp. 211–216, 2013.View at: Google Scholar
D. Tousch, A.-D. Lajoix, E. Hosy et al., “Chicoric acid, a new compound able to enhance insulin release and glucose uptake,” Biochemical and Biophysical Research Communications, vol. 377, no. 1, pp. 131–135, 2008.View at: Publisher Site | Google Scholar
C. Carazzone, D. Mascherpa, G. Gazzani, and A. Papetti, “Identification of phenolic constituents in red chicory salads (Cichorium intybus) by high-performance liquid chromatography with diode array detection and electrospray ionisation tandem mass spectrometry,” Food Chemistry, vol. 138, pp. 1062–1071, 2013.View at: Publisher Site | Google Scholar
K. Monde, T. Oya, A. Shirata, and M. Takasugi, “A guaianolide phytoalexin, cichoralexin, from Cichorium intybus,” Phytochemistry, vol. 29, no. 11, pp. 3449–3451, 1990.View at: Google Scholar
A. Papetti, D. Mascherpaa, C. Carazzonea et al., “Identification of organic acids in Cichorium intybus inhibiting virulence-related properties of oral pathogenic bacteria,” Food Chemistry, vol. 138, no. 2-3, pp. 1706–1712, 2013.View at: Publisher Site | Google Scholar
Bais, H. P., & Ravishankar, G. A. (2001). Cichorium intybus L–cultivation, processing, utility, value addition and biotechnology, with an emphasis on current status and future prospects. Journal of the Science of Food and Agriculture, 81(5), 467-484.v
Van Arkel, J., Vergauwen, et al (2012). Sink filling, inulin metabolizing enzymes and carbohydrate status in field grown chicory (Cichorium intybus L.). Journal of Plant Physiology, 169(15), 1520-1529
Ahmed, F. F., Ghareeb, O. A., & Al-Bayti, A. A. H. (2022). Nephro Defensive Efficiency of Cichorium Intybus Against Toxicity Caused by Copper Oxide Nanoparticles. Pakistan Journal of Medical & Health Sciences, 16(03), 542-542.
Sahan et al., 2017 Phenolics, antioxidant capacity and bioaccessibility of chicory varieties (Cichorium spp.) grown in Turkey.Food Chemistry, 217, 483–489.
Perović, J., Šaponjac, V. T., Kojić, J., Krulj, J., Moreno, D. A., García-Viguera, C., ... & Ilić, N. (2021). Chicory (Cichorium intybus L.) as a food ingredient–Nutritional composition, bioactivity, safety, and health claims: A review. Food chemistry, 336, 127676.
Kaur, N., & Gupta, A. K. (2002). Applications of inulin and oligofructose in health and nutrition. Journal of biosciences, 27(7), 703-714.
Janda, K., Gutowska, I., Geszke-Moritz, M., & Jakubczyk, K. (2021). The common cichory (Cichorium intybus L.) as a source of extracts with health-promoting properties—A review. Molecules, 26(6), 1814.
Street, R.A.; Sidana, J.; Prinsloo,2020 G. Cichorium Intybus: Traditional Uses, Phytochemistry, Pharmacology, andToxicology.Availableonline: https://www.hindawi.com/journals/ecam/2013/579319/ (accessed on 10 July 2020).
Duke, J. A. (2004). Handbook of medicinal herbs. CRC Press, Boca Raton, FL.
Bais, HP., Venkafesh, RT., Chandrashkar, A. and Ravishankar, GA. (2001). Agrobactenium rhizogenes mediated transformation of Witloof chicory - In vitro shoot regeneration and induction of flowering. Curr. Sci., 80: 83-87.
Chang, S.T. and Cheng, S.S. (2002). Antitermitic activity of leaf essential oils and components from Cinnamomum osmophleum. J. Agric. Food Chem., 50: 1389- 1392.
Edris, A.E. (2007). Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: A Review. Phytother. Res., 21: 308-323.
Flores, H.E., Vivanco, J.M. and Loyola-Vargas, V.M. (1999). Radicle biochemistry: the biology of root-specific metabolism. Trends Plant Sci., 4: 220-226.
Goel, M. K., Goel, S., Banerjee, S., Shanker, K., & Kukreja, A. K. (2010). Agrobacterium rhizogenes-mediated transformed roots of Rauwolfia serpentina for reserpine biosynthesis. Med Aromat Plant Sci Biotechnol, 4, 8-14.