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Background: The clinical success of indirect restorations is influenced by a variety of factors, including the choice of appropriate cement. With the introduction of adhesive resin systems, the use of all-ceramic bonded coatings has increased. The purpose of this study was to review the adhesive agents and their clinical characteristics and requirements that help the dentist in selecting the appropriate adhesive cement in specific clinical conditions. Methods: The study was conducted using the keywords Clinical, Zirconia, Glass Ceramic, and Dental restoration (Toughening Transformation, Machining, Performance) and review of articles in library resources, books, PubMed, and ISI databases. The scope of the article search was mainly from 2000 onwards. Results: Since new materials are constantly marketed, it becomes more difficult to select the appropriate cement and teach the method of application. Proper selection and knowledge of the nature of the material are of great importance because only then the dentist can apply the appropriate surface preparation to be cemented. Conventional cement is superior when the desired compressive strength, minimum layer thickness, and low solubility in water are desired. Of course, these types of cement require the ideal preparation of the desired tooth. Ordinary cement is used to bond non-etching porcelain. On the other hand, resin cement is a better choice for metal-free restorations due to its superior physical properties and more beauty than conventional cement. Conclusion: Despite the appropriate clinical results in short-term research, long-term clinical and laboratory studies on zirconia and glass and ceramic restorations are still needed.
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