Nt Pro Brain Natriuretic Peptide Levels in Cardiac Asymptomatic Type 2 Diabetes Mellitus Patients
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Abstract
Heart failure is twice more common in diabetics than in non-diabetics. Nt pro-BNP level increases in symptomatic and asymptomatic left ventricular dysfunction with hemodynamic overload. Recent advances in treating heart failure have improved survival for diabetics and non-diabetics. However, the case fatality rate is double in people with diabetes compared with non-diabetics. Thus, Nt Pro-BNP is beneficial for screening heart failure risk in diabetic patients.
AIM: To estimate Nt Pro Brain Natriuretic Peptide (Nt Pro-BNP) levels in asymptomatic cardiac type 2 diabetes mellitus patients.
METHODS: Patients attending BLDE (Deemed to be University) Shri BM Patil Medical College Hospital with diagnosed Diabetes Mellitus as per WHO criteria were selected for the study. The study’s nature and purpose were explained to patients, and informed consent was taken from those willing to participate.
RESULTS: The study evaluated the correlation between Nt pro-BNP levels, left ventricular diastolic dysfunction, and left ventricular ejection fraction. There was a positive correlation between Nt pro-BNP levels and diastolic dysfunction. (P value is < 0.0001) .There was a negative correlation between Nt pro-BNP and ejection fraction. (‘r’- 0.882; ‘p’ < 0.001).
CONCLUSION: Grades of diastolic dysfunction and pro-BNP had a positive correlation, and LVEF pro-BNP BNP had a negative correlation. This study can therefore infer that measuring the levels of Nt pro-BNP in patients with diabetes will therefore be helpful in the early detection of heart failure and predicting its prognosis and adverse outcomes.
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References
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