Nt Pro Brain Natriuretic Peptide Levels in Cardiac Asymptomatic Type 2 Diabetes Mellitus Patients

Main Article Content

Sai Santosh Jajimi
S. S. Devarmani
Basavaraj Devaranavadagi
S. M. Biradar


Background of the story
Heart failure is twice more common in diabetics than in non-diabetics. Nt pro-BNP level increases in symptomatic and asymptomatic left ventricular dysfunction with hemodynamic overload. Recent advances in treating heart failure have improved survival for diabetics and non-diabetics. However, the case fatality rate is double in people with diabetes compared with non-diabetics. Thus, Nt Pro-BNP is beneficial for screening heart failure risk in diabetic patients.
AIM: To estimate Nt Pro Brain Natriuretic Peptide (Nt Pro-BNP) levels in asymptomatic cardiac type 2 diabetes mellitus patients.
METHODS: Patients attending BLDE (Deemed to be University) Shri BM Patil Medical College Hospital with diagnosed Diabetes Mellitus as per WHO criteria were selected for the study. The study’s nature and purpose were explained to patients, and informed consent was taken from those willing to participate.
RESULTS: The study evaluated the correlation between Nt pro-BNP levels, left ventricular diastolic dysfunction, and left ventricular ejection fraction. There was a positive correlation between Nt pro-BNP levels and diastolic dysfunction. (P value is < 0.0001) .There was a negative correlation between Nt pro-BNP and ejection fraction. (‘r’- 0.882; ‘p’ < 0.001).

CONCLUSION: Grades of diastolic dysfunction and pro-BNP had a positive correlation, and LVEF pro-BNP BNP had a negative correlation. This study can therefore infer that measuring the levels of Nt pro-BNP in patients with diabetes will therefore be helpful in the early detection of heart failure and predicting its prognosis and adverse outcomes.

Article Details

How to Cite
Sai Santosh Jajimi, S. S. Devarmani, Basavaraj Devaranavadagi, & S. M. Biradar. (2023). Nt Pro Brain Natriuretic Peptide Levels in Cardiac Asymptomatic Type 2 Diabetes Mellitus Patients . Journal of Coastal Life Medicine, 11(2), 1625–1630. Retrieved from https://www.jclmm.com/index.php/journal/article/view/1214


Domanski M, Krause-Steinrauf H, Deedwania P, Follmann D, Ghali JK, Gilbert E, Haffner S, Katz R, Lindenfeld J, Lowes BD, Martin W, McGrew F, Bristow MR, BEST Investigators The effect of diabetes on outcomes of patients with advanced heart failure in the BEST trial. J Am Coll Cardiol. 2003;42:914–922 DOI: 10.1016/s0735-1097(03)00856-8

Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979;241:2035–2038. DOI: 10.1001/jama.241.19.2035

Farnsworth CW, Bailey AL, Jaffe AS, Scott MG. Diagnostic concordance between Pro BNP and BNP for suspected heart failure. Clin Biochem 2018;59(6):50-5. DOI: 10.1016/j.clinbiochem.2018.07.002

Song BG, Jeon ES, Kim YH, Kang MK, Doh JH, Kim PH, Ahn SJ, Oh HL, Kim HJ, Sung JD, Lee SC, Gwon HC, Kim JS, Kim DK, Lee SH, Hong KP, Park JE, Lee SY, Lee JK. Correlation between levels of N-terminal pro-B-type natriuretic peptide and degrees of heart failure. Korean J Intern Med. 2005 Mar;20(1):26-32. doi: 10.3904/kjim.2005.20.1.26.

Dhungana SP, Karki P, Lamsal M. Utility of N-terminal pro-brain natriuretic peptide in detecting diastolic dysfunction in asymptomatic hypertensive patients: comparison with echocardiography. J Cardiovasc Thorac Res. 2019;11(1):14-18. Epub 2019 Mar 13. doi: 10.15171/jcvtr.2019.03.

Gong H, Wang X, Shi YJ, Shang WJ, Ling YI, Pan LJ, Shi HM. Correlation between brain natriuretic peptide levels and the prognosis of patients with left ventricular diastolic dysfunction. Exp Ther Med. 2016 Jun;11(6):2583-2589. Epub 2016 Mar 30. doi: 10.3892/etm.2016.3203.

Hamano K, Nakadaira I, Suzuki J, Gonai M. N-terminal fragment of probrain natriuretic peptide is associated with diabetes microvascular complications in type 2 diabetes. Vasc Health Risk Manag. 2014 Oct 3;10:585-9.. Erratum in: Vasc Health Risk Manag. 2014;10:649. doi: 10.2147/VHRM.S67753

Rosiak M, Postula M, Kaplon-Cieslicka A, Trzepla E, Czlonkowski A, Filipiak KJ, Opolski G. Metformin treatment may be associated with decreased levels of NT-proBNP in patients with type 2 diabetes. Adv Med Sci. 2013;58(2):362-8.. doi: 10.2478/ams-2013-0009

Bertoni AG, Hundley WG, Massing MW, Bonds DE, Burke GL, Goff DC Jr. Heart failure prevalence, incidence, and mortality in the elderly with diabetes. Diabetes Care. 2004 Mar;27(3):699-703. doi: 10.2337/diacare.27.3.699.