A Study on Granules for Oral Suspension of Fixed Dose Combination of Analgesic Activities

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Published: May 29, 2023
Keywords:
Paracetamol Mefenamic acid Granules wet granulation analgesics

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Swetha M.
Sarojini Naidu Vanita Pharmacy Maha Vidhyalaya Tarnaka, Secunderabad
Lurdhumary K.
Associate professor, Department of pharmaceutical analysis, Nirmala college of pharmacy, NH 16 Service Rd, Mangalagiri, Mandal, Atmakur, Andhra Pradesh 522503
Rama B.
Department of pharmaceutics, Malla Reddy Institute of Pharmaceutical Sciences, Affiliated to JNTUH
K. Sudhamani
Department of pharmaceutics, Malla Reddy Institute of Pharmaceutical Sciences, Affiliated to JNTUH
Jahasultana Mohammed
Assistant professor, Department of pharmaceutics, koneru lakshmaiah education foundation, vaddeswaram, A.P, India
Sunil Mekala
Associate professor, Department of Pharmaceutics, Vishwa Bharathi College of Pharmaceutical Sciences, Perecherla, Guntur
Kiran Gerapati
Associate professor, Department of pharmacology, A.M Reddy memorial college of pharmacy, Petlurivaripalem, narasaopet, guntur

Abstract

Paracetamol and Mefenamic acid Granules for Oral Suspension formulation was prepared by granulation method. These two drugs are used as analgesics and the combination of the drug will increase the pharmacological activity. The formulations were prepared based on the release of the drug and taste of the suspension. These granules have shown increased bioavailability. The solubility of the drug can be increased. The granules formed by wet granulation using rapid mixer granulator have greater drug release. This type of formulation is not available in market. The drugs Paracetamol and Mefenamic acid are compatible with each other. The dosage form is Granules for Oral Suspension, so it should be dispensed in sachet, a readily available dosage form, which does not Effect the stability of drug. It is a unit dosage form, so it avoids over dosing. The drug release was rapid and has good pharmacological action.

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How to Cite
M., S. ., K., L. ., B., R. ., Sudhamani, K. ., Mohammed, J. ., Mekala, S. ., & Gerapati, K. . (2023). A Study on Granules for Oral Suspension of Fixed Dose Combination of Analgesic Activities. Journal of Coastal Life Medicine, 11(2), 1688 –. Retrieved from https://www.jclmm.com/index.php/journal/article/view/1237
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Vol. 11: Number 2, 2023
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