A Study on Granules for Oral Suspension of Fixed Dose Combination of Analgesic Activities

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Swetha M.
Lurdhumary K.
Rama B.
K. Sudhamani
Jahasultana Mohammed
Sunil Mekala
Kiran Gerapati


Paracetamol and Mefenamic acid Granules for Oral Suspension formulation was prepared by granulation method. These two drugs are used as analgesics and the combination of the drug will increase the pharmacological activity. The formulations were prepared based on the release of the drug and taste of the suspension. These granules have shown increased bioavailability. The solubility of the drug can be increased. The granules formed by wet granulation using rapid mixer granulator have greater drug release. This type of formulation is not available in market. The drugs Paracetamol and Mefenamic acid are compatible with each other. The dosage form is Granules for Oral Suspension, so it should be dispensed in sachet, a readily available dosage form, which does not Effect the stability of drug. It is a unit dosage form, so it avoids over dosing. The drug release was rapid and has good pharmacological action.

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M., S. ., K., L. ., B., R. ., Sudhamani, K. ., Mohammed, J. ., Mekala, S. ., & Gerapati, K. . (2023). A Study on Granules for Oral Suspension of Fixed Dose Combination of Analgesic Activities. Journal of Coastal Life Medicine, 11(2), 1688 –. Retrieved from https://www.jclmm.com/index.php/journal/article/view/1237


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