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The goal of this study was to create and test an ethosomal gel formulation of bifonazole. Ethosomes are a new lipid carrier that can be utilised to deliver drugs transdermally. The study's main goal is to improve the permeability of Bifonazole, a broad-spectrum antifungal imidazole medication. It is a class IV medicine with limited permeability and solubility, hence it has been loaded into one of the best vesicular systems, ethosomes, to boost permeability and solubility. Ethosomes are made using hot process by taking varying quantities of ethanol and lecithin. The drug entrapment efficiency, vesicle shape, and size of the produced formulations were all examined. The highest entrapment efficiency (95.99%) was found in F5 ethosomal vesicles containing 3% w/w lecithin and 30% w/w ethanol and were put into three different percentages of Carbopol gels (1%, 1.5%, and 2%). pH, drug content, viscosity, spreadability, and in-vitro diffusion investigations are performed on all gels. EG1 (1%) demonstrated the highest penetration rate and was proven to be stable. The study revealed that bifonazole ethosomal gel can successfully improve drug bioavailability by penetration enhancement, reduce the frequency of administration, and improve patient compliance. The ethosomal gel could be successfully made at a low cost and had better drug release than traditional dosage forms.
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