Formulation and Evaluation of Bifonazole Ethosomal Gel for Enhanced Topical Delivery
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Abstract
The goal of this study was to create and test an ethosomal gel formulation of bifonazole. Ethosomes are a new lipid carrier that can be utilised to deliver drugs transdermally. The study's main goal is to improve the permeability of Bifonazole, a broad-spectrum antifungal imidazole medication. It is a class IV medicine with limited permeability and solubility, hence it has been loaded into one of the best vesicular systems, ethosomes, to boost permeability and solubility. Ethosomes are made using hot process by taking varying quantities of ethanol and lecithin. The drug entrapment efficiency, vesicle shape, and size of the produced formulations were all examined. The highest entrapment efficiency (95.99%) was found in F5 ethosomal vesicles containing 3% w/w lecithin and 30% w/w ethanol and were put into three different percentages of Carbopol gels (1%, 1.5%, and 2%). pH, drug content, viscosity, spreadability, and in-vitro diffusion investigations are performed on all gels. EG1 (1%) demonstrated the highest penetration rate and was proven to be stable. The study revealed that bifonazole ethosomal gel can successfully improve drug bioavailability by penetration enhancement, reduce the frequency of administration, and improve patient compliance. The ethosomal gel could be successfully made at a low cost and had better drug release than traditional dosage forms.
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References
Gangwar S, Singh S, Garg G. Ethosomes: A Novel tool for Drug Delivery through the Skin. Journal of Pharmacy Research. 2010;3(4):688-691.
Kumar KP, Radhika PR, Sivakumar T. Ethosomes: A Priority in Transdermal Drug Delivery. International Journal of Advances in Pharmaceutical Sciences. 2010; 1:111-121.
Heeremans JLM, Gerristen HR, Meusen SP, Mijnheer FW, Gangaram RS, Panday G, Prevost R, Kluft C, Crommelin DJA. The preparation of tissue type plasminogen activator (t- PA) containing liposomes: entrapment efficacy and ultracentrifugation damage. Journal of Drug Targeting. 1995; 3:301.
Asbill CS, El-Kattan AF, Michniak B. Enhancement of transdermal drug delivery: chemical and physical approaches. Critical Reviews in Therapeutic Drug Carrier Systems. 2000; 17:621.
Touitou E, Dayan N, Levi-Schaffer F, Piliponsky A. Novel lipid vesicular system for enhanced delivery. Journal of Lipid Research. 1998; 8:113.
Verma P, Pathak K. Therapeutic and cosmeceutical potential of ethosomes: An overview. Journal of Advanced Pharmaceutical Technology & Research. 2010; 1:274-82.
Ainbinder D, Touitou E. Testosterone ethosomes for enhanced transdermal delivery. Drug delivery. 2005; 12(5):297-303.
Barry B W. Novel mechanisms and devices to enable successful transdermal drug delivery. European Journal of Pharmaceutical Sciences. 2001; 14(2):101-114.
Paolino Donatella, Lucania Giuseppe, Mardente Domenico. Ethosome for skin delivery of ammonium glycyrrhizinate: In vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. Journal of Controlled Release. 2005; 106(1-2):99-110.
Nandy BC, Gupta RN, Rai VK. Transdermal Iontophoresis delivery of Atenolol in combination with penetration enhancers: optimization and evaluation on solution and gels. International Journal of Pharmaceutical Sciences and Drug Research. 2009; 1(2):91-99.
Divya Aggarwal, Ujjwal Nautiyal. Ethosomes: A Review. International journal of pharmaceutical and medicinal research. 2016; 4(4):354-363.
Verma P, Ram A. Effect of different penetration enhancers on skin permeation of drug using ethosomal carrier systems. Journal of Current Pharma Research. 2011; 5:42–44.
Prasanthi D, Lakshmi PK. Development of ethosomes with Taguchi robust design-based studies for transdermal delivery of alfuzosin hydrochloride. International Current Pharmaceutical Journal. 2012; 1(11):370– 375.
Limsuwan T, Amnuaikit T. Development of ethosomes containing mycophenolic acid. Procedia Chemistry. 2012; 4:328–335.
Xingyan Liu, Hong Liu, Jianqiang Liu, Zhiwei He. Preparation of a ligustrazine ethosome patch and its evaluation in vitro and in vivo. International Journal of Nanomedicine. 2011; 6:241–247.
Xiaoliang Zhu, Fuli Li, Xuebiao Peng, Kang Zeng. Formulation and Evaluation of lidocaine base ethosomes for transdermal delivery. Anesthesia and analgesia. 2013; 117(2):352–357.
Jian-Ping Zhang, Yu-Hui Wei, Yan Zhou, Yu-Qing Li. Ethosomes, binary ethosomes and transferosomes of terbinafine hydrochloride: a comparative study. Archives of Pharmacal Research. 2012; 35(1):109–117.
K Pavan Kumar, P. R. Radhika, T Shiva Kumar. Ethosomes: A Priority in Transdermal Drug Delivery. International Journal of Advances in Pharmaceutical Sciences. 2010;1(2):111-121.
Kavita Verma Shukla, Anamika Sharma, Monika Yadav. Formulation Development and Evaluation of Ethosomal Gel of Acyclovir for the Treatment of Herpes Zoster. Journal of drug delivery and therapeutics. 2019; 9(4-A):664-668.
Rekha B. Formulation and Characterization of Atorvastatin Ethosomal Gel. Journal of Drug Development and Delivery. 2018 ;1(1): 13-20.