Structural Changes in the Prostate of Old Rats with Chronic Alcoholism

Main Article Content

Radjabov Akhtam Boltaevich


Morphological and structural alterations in the prostate of aged rats due to prolonged drinking are discussed in this article. 18-month-old animals show moderate lymphocytic infiltration without tissue damage and lymphoid nodular development along with other modifications such as proliferative changes in the epithelium of the secretory sections, the detection of nodules inside the acini, and congestive, vascular abnormalities. As chronic alcoholism progresses in animals, the glandular parenchyma of the affected organs shrinks, lymphocytic infiltration causes tissue damage, and lymphoid nodules appear. As shown in the experiment, papillary structures develop and expand as a result of involutive changes including flattening of the acinar epithelium, reduction in the size of the acinus, and suppression of secretory activity.

Article Details

How to Cite
Radjabov Akhtam Boltaevich. (2023). Structural Changes in the Prostate of Old Rats with Chronic Alcoholism. Journal of Coastal Life Medicine, 11(2), 1757–1764. Retrieved from


Medical Morphometry / G. G. Avtandilov. - M: Medicine, 1990. - 384 pages. 1.

Second: E.N. Gorbunova and Davydova Risk factors for prostatic intraepithelial neoplasia and prostate cancer: a review of the literature D.A. Krupin V.N. Clinical Medicine. - 2011. - No. 1. - P. 79-83

Narcology and national leadership. Ivanets N.N., I.P. Anokhina, and M.A. Vinnikova. 2016; 944 pages: M.: GEOTAR - Media.

4. KamolovKh.Yo. Morphological features of the lung in chronic alcoholism // Journal "New Day in Medicine". - 2021. - No. 2 (34). - S. 235-237.

A.A. Muzhikyan, Ya.A. Gushchin, E.V. Belyaeva, M.N. Makarova, and V.G. Laboratory rat autopsy and organ retrieval technique // Message 1. Animals in laboratories for medical and scientific study: 2018. 2. DOI: 10.29296/10.29296/2618723X-2018-02-08.

Alcoholism, by Moiseev V.S. Toxic effects on vital organs, updated with new information for the second edition 2014, 480 M.: GEOTAR - Media.

Morphological alterations in organs in different kinds of alcoholic illness // Questions of Narcology. - 2012. - No. 3. - P. 34-40. 7. Pavlov A. L., Pavlova A. Z., Bogomolov D. V., Larev Z. V., Trofimova I. N.

Guidelines for the use of animals in toxicological research. 8. Sidorov, P.I. Arkhangelsk: P.I. Sidorova, 2002; 15 p.

9 Khokhryakov A.V. Abstract of the thesis. dis.... cand. honey. Sciences. - Nizhny Novgorod, 2009. Morpho-functional features of the male reproductive system in acute and chronic alcohol intoxication. - 22p.10.Alcohol's impact on the heart. In: Gardner J.D. and Mouton A.J. 2015; 5(2):791-802 in Compr Physiol.

Reduction in excessive drinking as a treatment result in alcohol dependency. Gastfriend, D.R., Garbutt, J.C., Pettinati, H.M., Forman, R.F. Journal of Substance Abuse Treatment. Vol.33, No.1. (2017), pp.71-80.

Constrictor responses of cerebral resistance arterioles in male and female rats exposed to prenatal alcohol // 2019 Physiological Reports, 9, e15079 Cananzi, S., and Mayhan, W. Physiological Reports 9 (April 2019): e15079.

Postnatal ontogenetic changes in the body mass index and prostate morphological characteristics in male rats. Radjabov, A.B., British Medical Journal, 2022, volume 2, issue 1, pages 278-283.

Prostate microanatomy of adult rats and its response modifications in chronic drinking // American Journal of Medicine and Medical Sciences. 2023. Vol. 13. No. 7. Pages 867-871.