Thyroid Dysfunction & Pregnancy

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Published: Nov 10, 2022
Keywords:
Pregnancy, Thyroid dysfunction, thyroid hormones

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Mr. Ekagra Panwar
MBBS Student, Batch 2019-20, Santosh Medical College and Hospital, Santosh deemed to be University, Ghaziabad, Uttar Pradesh -201009
Dr. Juhi Aggarwal
Professor & Head, Department of Biochemistry, Santosh Medical College and Hospital, Santosh deemed to be University, Ghaziabad, Uttar Pradesh -201009
Dr. Jyoti Batra
Professor, Department of Biochemistry, Santosh Medical College and Hospital, Santosh deemed to be University, Ghaziabad, Uttar Pradesh -201009.

Abstract

Thyroid disorder is the second most common endocrine disorder in pregnancy, after diabetes. The increased prevalence of thyroid disorders makes it necessary to start universal screening of pregnant women for thyroid disorders which would help in the early identification and rectification of thyroid disorders in pregnant women. Further, early screening and treatment of thyroid disorders would prevent to a large extent the incidence of thyroid disorders in the newborns, which is one of the leading causes of mental retardation.

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How to Cite
Mr. Ekagra Panwar, Dr. Juhi Aggarwal, & Dr. Jyoti Batra. (2022). Thyroid Dysfunction & Pregnancy. Journal of Coastal Life Medicine, 10(3), 57–67. Retrieved from https://www.jclmm.com/index.php/journal/article/view/142
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Vol. 10: Number 3, 2022
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References

Carney LA, Quinlan JD, West JM. Thyroid disease in pregnancy. American family physician. 2014 Feb 15;89(4):273-8.

Morganti S, Ceda GP, Saccani M, Milli B, Ugolotti D, Prampolini R, Maggio M, Valenti G, Ceresini G. Thyroid disease in the elderly: sex-related differences in clinical expression. Journal of endocrinological investigation. 2005 Jan 1;28(11 Suppl Proceedings):101-4.

Mahadik K, Choudhary P, Roy PK. Study of thyroid function in pregnancy, its feto-maternal outcome; a prospective observational study. BMC Pregnancy and Childbirth. 2020 Dec;20(1):1-7.

Nambiar V, Jagtap VS, Sarathi V, Lila AR, Kamalanathan S, Bandgar TR, Menon PS, Shah NS. Prevalence and impact of thyroid disorders on maternal outcome in Asian-Indian pregnant women. Journal of thyroid research. 2011 Mar 9;2011.

Mullur R, Liu YY, Brent GA. Thyroid hormone regulation of metabolism. Physiological reviews. 2014 Apr;94(2):355-82.

Visser TJ. Regulation of thyroid function, synthesis and function of thyroid hormones. Thyroid Diseases Endocrinology. Springer, Cham. 2018:1-30.

Alemu A, Terefe B, Abebe M, Biadgo B. Thyroid hormone dysfunction during pregnancy: A review. International Journal of Reproductive BioMedicine. 2016 Nov;14(11):677.

Leung AM. Thyroid function in pregnancy. Journal of trace elements in medicine and biology. 2012 Jun 1;26(2-3):137-40.

Rajput R, Singh B, Goel V, Verma A, Seth S, Nanda S. Trimester-specific reference interval for thyroid hormones during pregnancy at a Tertiary Care Hospital in Haryana, India. Indian journal of endocrinology and metabolism. 2016 Nov;20(6):810.

Ahmed RG. Maternal-fetal thyroid interactions. In the thyroid hormone. 2012 Jul 18:125-56.

Kennedy RL, Darne J. The role of hCG in regulation of the thyroid gland in normal and abnormal pregnancy. Obstetrics and gynecology. 1991 Aug 1;78(2):298-307.

Chung HR. Iodine and thyroid function. Annals of Pediatric Endocrinology & Metabolism. 2014 Mar;19(1):8.

Glinoer D, Lemone M. Goiter and pregnancy: a new insight into an old problem. Thyroid. 1992;2(1):65-70.

Prummel MF, Wiersinga WM. Thyroid autoimmunity and miscarriage. European Journal of Endocrinology. 2004 Jun 1;150(6):751-6.

Cignini P, Cafà EV, Giorlandino C, Capriglione S, Spata A, Dugo N. Thyroid physiology and common diseases in pregnancy: review of literature. Journal of prenatal medicine. 2012 Oct;6(4):64.

Bjoro T, Holmen J, Krüger O, Midthjell K, Hunstad K, Schreiner T, Sandnes L, Brochmann H. Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trondelag (HUNT). European journal of endocrinology. 2000 Nov 1;143(5):639-47.

Yassaee F, Farahani M, Abadi AR. Prevalence of subclinical hypothyroidism in pregnant women in Tehran-Iran. International journal of fertility & sterility. 2014 Jul;8(2):163.

Korevaar TI, Medici M, de Rijke YB, Visser W, de Muinck Keizer-Schrama SM, Jaddoe VW, Hofman A, Ross HA, Visser WE, Hooijkaas H, Steegers EA. Ethnic differences in maternal thyroid parameters during pregnancy: the Generation R study. The Journal of Clinical Endocrinology & Metabolism. 2013 Sep 1;98(9):3678-86.

Beynon ME, Pinneri K. An overview of the thyroid gland and thyroid-related deaths for the forensic pathologist. Academic forensic pathology. 2016 Jun;6(2):217-36.

https://www.niddk.nih.gov/health-information/endocrine-diseases/pregnancy-thyroid-disease.

https://www.slideshare.net/drcfng/thyroid-gland.

Lee J, Yi S, Kang YE, Kim HW, Joung KH, Sul HJ, Kim KS, Shong M. Morphological and functional changes in the thyroid follicles of the aged murine and humans. Journal of pathology and translational medicine. 2016 Nov;50(6):426.

http://www.biosciencenotes.com/thyroid-gland-and-thyroid-hormones.

Szkudlinski MW, Fremont V, Ronin C, Weintraub BD. Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. Physiological reviews. 2002 Apr 1;82(2):473-502.

Bizhanova A, Kopp P. The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology. 2009 Mar 1;150(3):1084-90.

Carvalho DP, Dupuy C. Thyroid hormone biosynthesis and release. Molecular and cellular endocrinology. 2017 Dec 15; 458:6-15.

Canaris GJ, Steiner JF, Ridgway EC. Do traditional symptoms of hypothyroidism correlate with biochemical disease? Journal of general internal medicine. 1997 Sep;12(9):544-50.

Brent GA. Mechanisms of thyroid hormone action. The Journal of clinical investigation. 2012 Sep 4;122(9):3035-43.

Gaitonde DY, Rowley KD, Sweeney LB. Hypothyroidism: an update. South African Family Practice. 2012 Sep 1;54(5):384-90.

Reid JR, Wheeler SF. Hyperthyroidism: diagnosis and treatment. American family physician. 2005 Aug 15;72(4):623-30.

Nilsson M, Fagman H. Development of the thyroid gland. Development. 2017 Jun 15;144(12):2123-40.

Pekonen F, Alfthan H, Stenman UH, Ylikorkala O. Human chorionic gonadotropin (hCG) and thyroid function in early human pregnancy: circadian variation and evidence for intrinsic thyrotropic activity of hCG. The Journal of Clinical Endocrinology & Metabolism. 1988 Apr 1;66(4):853-6.

Guillaume J, Schussler GC, Goldman J, Wassel P, Bach L. Components of the Total Serum Thyroid Hormone Concentrations during Pregnancy: High Free Thyroxine and Blunted Thyrotropin (TSH) Response to TSH Releasing Hormone in the First Trimester. The Journal of Clinical Endocrinology & Metabolism. 1985 Apr 1;60(4):678-84.

Soldin OP, Tractenberg RE, Hollowell JG, Jonklaas J, Janicic N, Soldin SJ. Trimester-specific changes in maternal thyroid hormone, thyrotropin, and thyroglobulin concentrations during gestation: trends and associations across trimesters in iodine sufficiency. Thyroid. 2004 Dec 1;14(12):1084-90.

Gahlawat P, Singh A, Nanda S, Kharb S. Thyroid dysfunction in early pregnancy and spontaneous abortion. Biomedical and Biotechnology Research Journal (BBRJ). 2017 Jan 1;1(1):81.

Lazarus J. Thyroid regulation and dysfunction in the pregnant patient. Endotext [Internet]. 2016 Jul 21.

Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M. Thyroid Regulation and Dysfunction in the Pregnant Patient--Endotext.

Burrow GN, Fisher DA, Larsen PR. Maternal and fetal thyroid function. New England Journal of Medicine. 1994 Oct 20;331(16):1072-8.

Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, O'Heir CE, Mitchell ML, Hermos RJ, Waisbren SE, Faix JD. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. New England Journal of Medicine. 1999 Aug 19;341(8):549-55.

Shan ZY, Chen YY, Teng WP, Yu XH, Li CY, Zhou WW, Gao B, Zhou JR, Ding B, Ma Y, Wu Y. A study for maternal thyroid hormone deficiency during the first half of pregnancy in China. European journal of clinical investigation. 2009 Jan;39(1):37-42.

Zarghami N, Rohbani-Noubar M, Khosrowbeygi A. Thyroid hormones status during pregnancy in normal Iranian women. Indian Journal of Clinical Biochemistry. 2005 Jul;20(2):182-5.

De Leo S, Pearce EN. Autoimmune thyroid disease during pregnancy. The Lancet Diabetes & Endocrinology. 2018 Jul 1;6(7):575-86.

Teng W, Shan Z, Patil-Sisodia K, Cooper DS. Hypothyroidism in pregnancy. The lancet Diabetes & endocrinology. 2013 Nov 1;1(3):228-37.

Dave A, Maru L, Tripathi M. Importance of Universal screening for thyroid disorders in first trimester of pregnancy. Indian journal of endocrinology and metabolism. 2014 Sep;18(5):735.

Kostoglou-Athanassiou I, Ntalles K. Hypothyroidism-new aspects of an old disease. Hippokratia. 2010 Apr;14(2):82.

Casey BM, Dashe JS, Wells CE, McIntire DD, Byrd W, Leveno KJ, Cunningham FG. Subclinical hypothyroidism and pregnancy outcomes. Obstetrics & Gynecology. 2005 Feb 1;105(2):239-45.

Sahay RK, Nagesh VS. Hypothyroidism in pregnancy. Indian journal of endocrinology and metabolism. 2012 May;16(3):364.

Nazarpour S, Tehrani FR, Simbar M, Azizi F. Thyroid dysfunction and pregnancy outcomes. Iranian journal of reproductive medicine. 2015 Jul;13(7):387.

Moog NK, Entringer S, Heim C, Wadhwa PD, Kathmann N, Buss C. Influence of maternal thyroid hormones during gestation on fetal brain development. Neuroscience. 2017 Feb 7; 342:68-100.

Grigoriu C, Cezar C, Grigoras M, Horhoianu I, Parau C, Vîrtej P, Lungu A, Horhoianu V, Poiana C. Management of hyperthyroidism in pregnancy. Journal of medicine and life. 2008 Nov 15;1(4):390.

Moleti M, Di Mauro M, Sturniolo G, Russo M, Vermiglio F. Hyperthyroidism in the pregnant woman: maternal and fetal aspects. Journal of clinical & translational endocrinology. 2019 Jun 1; 16:100190.

Kobaly K, Mandel SJ. Hyperthyroidism and pregnancy. Endocrinology and Metabolism Clinics. 2019 Sep 1;48(3):533-45.

Hage M, Zantout MS, Azar ST. Thyroid disorders and diabetes mellitus. Journal of thyroid research. 2011 Oct;2011.

Chiovato L, Magri F, Carlé A. Hypothyroidism in context: where we’ve been and where we’re going. Advances in therapy. 2019 Sep;36(2):47-58.

Soldin OP, Hilakivi-Clarke L, Weiderpass E, Soldin SJ. Trimester-specific reference intervals for thyroxine and triiodothyronine in pregnancy in iodine-sufficient women using isotope dilution tandem mass spectrometry and immunoassays. Clinica Chimica Acta. 2004 Nov 1;349(1-2):181-9.

Zhou M, Wang M, Li J, Luo X, Lei M. Effects of thyroid diseases on pregnancy outcomes. Experimental and therapeutic medicine. 2019 Sep 1;18(3):1807-15.

Nazarpour S, Ramezani Tehrani F, Simbar M, Azizi F. Pregnancy outcomes in pregnant women with hypothyroidism (A review Article). The Iranian Journal of Obstetrics, Gynecology and Infertility. 2014;17(126):17-26.

Sheehan MT. Biochemical testing of the thyroid: TSH is the best and, oftentimes, only test needed–a review for primary care. Clinical medicine & research. 2016 Jun 1;14(2):83-92.

Fröhlich E, Wahl R. Thyroid autoimmunity: role of anti-thyroid antibodies in thyroid and extra-thyroidal diseases. Frontiers in immunology. 2017 May 9;8:521.

Wang W, Teng W, Shan Z, Wang S, Li J, Zhu L, Zhou J, Mao J, Yu X, Li J, Chen Y. The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy. European Journal of Endocrinology. 2011 Feb 1;164(2):263-8.

Sarkar R. TSH comparison between chemiluminescence (Architect) and electrochemiluminescence (Cobas) immunoassays: an Indian population perspective. Indian journal of clinical biochemistry. 2014 Apr 1;29(2):189-95.

Cignini P, Cafà EV, Giorlandino C, Capriglione S, Spata A, Dugo N. Thyroid physiology and common diseases in pregnancy: review of literature. Journal of prenatal medicine. 2012 Oct;6(4):64.

Cooper DS. Subclinical hypothyroidism. New England Journal of Medicine. 2001 Jul 26;345(4):260-5.

Hennessey JV, Espaillat R. Subclinical hypothyroidism: a historical view and shifting prevalence. International journal of clinical practice. 2015 Jul;69(7):771-82.

Jacob JJ. Subclinical hypothyroidism in the first trimester of pregnancy in North India. Indian journal of endocrinology and metabolism. 2013 Oct;17(Suppl1): S160.

Grewal E, Khadgawat R, Gupta N. Assessment of iodine nutrition in pregnant north Indian subjects in three trimesters. Indian journal of endocrinology and metabolism. 2013 Mar;17(2):289.

Koulouri O, Gurnell M. How to interpret thyroid function tests. Clinical medicine. 2013 Jun;13(3):282.

Balucan FS, Morshed SA, Davies TF. Thyroid autoantibodies in pregnancy: their role, regulation and clinical relevance. Journal of thyroid research. 2013 Jan 1;2013.

Haddow JE, McClain MR, Lambert-Messerlian G, Palomaki GE, Canick JA, Cleary-Goldman J, Malone FD, Porter TF, Nyberg DA, Bernstein P, D'Alton ME. Variability in thyroid-stimulating hormone suppression by human chronic gonadotropin during early pregnancy. The Journal of Clinical Endocrinology & Metabolism. 2008 Sep 1;93(9):3341-7.

De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, Eastman CJ, Lazarus JH, Luton D, Mandel SJ, Mestman J. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism. 2012 Aug 1;97(8):25

Harshvardhan, Tomo, S.,Rawat, A., Aggarwal, J. The Increased Prevalence of Thyroid Dysfunction in First Trimester Pregnancy in a Tertiary Care Centre and the Significance of Universal Screening;2021.Journal of Datta Meghe Institute of Medical Sciences University, Volume 16, Issue 3, July-September 2021, Pages 457-461.