Anti-Diabetic Effects of Leucas URTICAEFOLIA –HAM. in STZ-Induced Diabetic Rats

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Test procedure with a starting dose of 50mg/kg body weight
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Published: Dec 15, 2022
Keywords:
Leucas Urticaefolia Pharmacological aspects anti-diabetic medicinal plants STZ-induced diabetic rats

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J. John Wesley
Research scholar, department of pharmacy,faculty of engineering and technology, Annamalai University, Chidambaram, Tamilnadu, India.
A. Anton Smith
Associate professor, department of pharmacy, faculty of engineering and technology, Annamalai University, Chidambaram, Tamilnadu, India.
N. Balakrishnan
Professor, S.A.Raja pharmacy college, vadakkankulam, Tirunelveli district, Tamilnadu, India

Abstract

Aims/hypothesis The main objective of this study is to explore the anti-diabetic effects of Leucas Urticaefolia (LU) in STZ-induced diabetic rats.


Methods In this research, we executed in vivo tests on a diabetic Wistar rat model. The studies were carried out, and we orally administered a LU extract and a control medication to streptozotocin (STZ)-induced diabetic rats to assess their anti-diabetic properties.


Results We discovered that a LU extract at a therapeutic dose of 400 mg/kg/body weight had a substantial effect on insulin reduction in STZ-induced rats as compared with the control group (P<0.001). Our histology results also revealed that the extract significantly improved pancreatic and liver histopathology.


Conclusion/ interpretation In vivo investigations demonstrated that LU has an anti-diabetic effect in STZ-induced diabetic rats.

Article Details

How to Cite
J. John Wesley, A. Anton Smith, & N. Balakrishnan. (2022). Anti-Diabetic Effects of Leucas URTICAEFOLIA –HAM. in STZ-Induced Diabetic Rats. Journal of Coastal Life Medicine, 10(3), 352–359. Retrieved from https://www.jclmm.com/index.php/journal/article/view/204
Issue
Vol. 10: Number 3, 2022
Section
Articles

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