Anti-Inflammatory Activity of Ethanol Extract of Crateva Nurvala Stem Bark on Carrageenan Induced Paw Edema in Rats

Abstract

Natural medicines, which are abundant in various vitamins and flavonoids, have been increasingly popular in recent years for the treatment of inflammation. When compared to standard allopathic medications, these natural therapies are predicted to be both safe and cost effective. With the goal of approximating its traditional and pharmaceutical usage against pain and inflammation disorders, this research examined the anti-inflammatory action of ethanol extract of stem bark of crateva nurvala.The anti-inflammatory effects of crateva nurvala (varun), an ethanol extract of crateva nurvala stem bark, were studied using in-vivo models. This research set out to determine if crateva nurvala ethanol extract had  anti-inflammatory effects when used against carrageenan-induced paw edema in rats at two distinct doses (200 and 400 mg/kg body weight). In rat models of carrageenan-induced edema, the extract demonstrated considerable anti-inflammatory efficacy at a dose of 400 mg/kg body weight, with a reduction in paw volume of 41.61% at 4 hours comparable (P< 0.05) to that caused by the standard medication indomethacin 74.49%.Phytochemical constituents in the ethanol extract of crateva nurvala stem bark, such as alkaloid, flavonoids, saponins, and tannins, work together to suppress inflammation. These compounds inhibit arachidonic acid metabolism, neutrophil degranulation, and enzyme systems that promote cell proliferation and regulate the complement system. Although these results are promising, further preclinical and clinical testing is required to confirm them.