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A young non diabetic male patient on treatment with sodium valproate for hypomanic phase of bipolar disorder, developed diabetic ketoacidosis and acute pancreatitis which is transient in nature after starting the patient on haloperidol and chlorpromazine medications. Patient condition improved and resolved completely with his sugar levels coming back to normal in six weeks of time. Acute pancreatitis and diabetic ketoacidosis manifesting combinedly is a very rare occurrence. This condition can be seen in patients who are on antipsychotic medications like sodium valproate, haloperidol and chlorpromazine. Hence it is important to monitor levels of blood glucose in patients who are on antipsychotic medications. This regular monitoring helps in preventing complications related to hyperglycaemia.
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Acute pancreatitis and diabetic ketoacidosis in non-diabetic person while on treatment with sodium valproate, chlorpromazine and haloperidol V D Laghate , S B Gupta