Quality By Design (QBD) Approach in Processing of Nanoparticles Loading Antifungal Drugs
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Abstract
"Quality by Design" (QbD) is a strategic process for development and manufacturing, it is aimed to make sure that a final pharmaceutical product performs as expected, both in terms of purity and efficacy. To achieve this, QbD implementation in the manufacturing process must be done clearly with defined objectives and proper risk management. Considering that it provides drug developers with a better understanding of manufacturing processes, reduces the frequency of batch failures, and therefore is data-driven, the QbD methodology contributes to the progressive manufacturing environment and provides a higher return on investment. Applying QbD in nano formulation can greatly impact advanced drug delivery. Particles with a diameter of less than 100 nm are known as nanoparticles, are extensively studied in nanotechnology, and have wide application in novel drug delivery systems, targeted sites, and dosing regimens. Controlling particle size, surface characteristics, and the release of pharmacologically active substances are the main criteria when formulating nanoparticles as a delivery system. As fungal infections are increasing rapidly which affect the skin, hair, nails, or mucous membranes and can also infect the lungs or other parts of your body, implementing QbD in the processing of nanoparticles loading antifungals might be of great need.
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