Beneficial Effect on Diabetic Nephropathy by Monotherapy as Well as their Combinations Therapy
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Abstract
Intracellular calcium has been found to play a major role in the development of renal damage in diabetic kidneys, and oxidative stress has been connected to diabetic nephropathy. Calcium antagonism may postpone diabetes-related renal deterioration. This research compared the effectiveness of monotherapy and combination treatment for treating diabetic nephropathy in people with type 2 diabetes that was produced in the lab. Experimentally induced type 2 diabetes in rats was evaluated using a variety of treatment regimens, including fosinopril (ACE Inh), olmesartan (ARB), glimepiride (SU), pioglitazone (TZDs), and diltiazem (CCB) alone and in combination. Due to their complementary mode of action and synergistic benefits, combination treatments are preferable to monotherapies for the treatment of diabetic nephropathy, as shown by the findings of the aforementioned studies.
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