Effects of Anesthesia Technics on Certain Cytokines for Patients Undergoing Surgery: A Clinical Diagnostic Study
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Abstract
Background: Change of circulating cytokines level were normally low and may be uncleared within 30 - 60 minutes during anesthesia. The concentration of most of cytokines increases at 2 - 4 hours after operation.
Materials and Methods: The prospective clinical diagnostic study was performed on 100 patients undergoing surgery. First blood samples were collected from the patients before induction and second samples were collected 6 hours after operation. Cytokine serum level tests were performed for all samples to diagnose the level of cytokine cell interleukin -6 (IL-6), interleukin -10 (IL-10), tumor necrosis factor -alpha (TNF-α) and interferon - gamma (INF-γ) pre- and post-operative.
Results: Most of patients operated with general anesthesia, The mean level of serum IL-6, IL-10 and TNF-α slightly increased after operation and significant differences were shown in patients whom under surgery for 2-3 hours (p<0.05) but significant changes of IFN-γ were higher (p<0.001). Significant elevations were seen after operation during general and mixed (spinal + general) anesthesia for IL-10 and TNF-α and IFN-γ. Post operative changes in mean serum level for IFN-γ was higher than the changes for IL-6, IL-10 and TNF-α and clearly significant were shown for patients who operated under GA or mix (SA+GA). Highly significant mean differences ratio (Before : After) anesthesia and surgery were shown for IL-10 during GA and SA+GA and INF-γ p<0.001.
Conclusion: General anesthesia significantly increases the serum level of IL-10, TNF-α and INF-γ rather than spinal anesthesia after operation. Therefore, spinal anesthesia and short-term operations not considerable and changes in the immune response for patients undergoing surgery
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References
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