Effect of Sustained Released Tablet of Different Herbal Plants on Histone Deacetylase Enzyme-1 Level in Various Tissues of Wistar Rats
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Abstract
The aim of this work was to compare sustained-release tablets of different herbal plants. Antiarthritic activity of Trapa bispinosa, Cassia uniflora, Bosevillaserrata, and Cissus quadragularis. One or more joints can get inflamed with arthritis, causing aches, swellings, rigidity, cartilage damage, and erosion of the underlying bone. Researchers are looking for new potential anti anti-inflammatory treatment options because of the adverse side effects of steroidal and non-steroidal anti-inflammatory medications time-release tablets made from various herbal plants. Trapa bispinosa, Cassia uniflora, Bosevillaserrata, and Cissus quadragularis were tested for Histone Deacetylase 1 assay and anti-arthritic activity against Carrageenan, Histamine, and Freund's complete adjuvant-induced rat paw edema. Extended-release tablets showed substantial activity (p<0.01) against all inflammatory agents used in adose-dependent manner. Diclofenac sodium (20 mg/kg) was used as reference for comparison.
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Shaikh S, Dubey R, Joshi Y, Kadam V. World J Pharm Pharm Sci 2012;1(3):911-921.
Ambikar DB, Harle UN, Khandare RA, Bore VV, Vyawahare NS. Ind J ExpBiol 2009;48:378-82.
Parasuraman S, Thing GS, Dhanaraj SA. Polyherbal formulation: Concept of ayurveda. Pharmacogn Rev 2014;8:73-80.
Jayakumar RV. Herbal medicine for type-2 diabetes. Int J Diabetes Dev Ctries 2010;30:111-2.
Petchi RR, Vijaya C, Parasuraman S. Antidiabetic activity of polyherbal formulation in streptozotocin-Nicotinamide induced diabetic Wistar rats. J Tradit Complement Med 2014;4:108-17.
Rajendran R, Krishnakumar E. Anti-Arthritic Activity of Premna serratifolia Linn., Wood against Adjuvant Induced Arthritis. Avicenna J Med Biotechnol. 2010;2:101-6.
OECD. Guideline for testing of chemicals 423 (online); 2001 [ cited on 2010 Feb 11]. Available from URL: http://iccvam. Niehs. Nih. Gov/SuppDocs/ OECD/OECD GL423. pdf.Surender Singh, Vinod Nair and Y.K. Gupta, Antiarthritic Activity of Majoon suranjan ( a polyherbal unani formulation) in rat. Indian Journal of Medical Research, 2011; vol 134, pp-384-388.
OECD. Guideline for testing of chemicals 425 (online); 2001 [ cited on 2010 Feb 11]. Available from URL: http://iccvam. Niehs. Nih. Gov/SuppDocs/ OECD/OECD GL425. pdf.
Rajaram, Cuddapah et al. “Evaluation of anti-arthritic activity of caesalpinia pulcherrima in freund’s complete adjuvant induced arthritic rat model.” Journal of Young Pharmacists 7 (2015): 132.
GraunsenburgerR,GurkinJ,ZupkavitzG,LaggerS,HagelkruysA,KennerL,SeiserC.CellCycle2011;10:406-12.