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Background: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. It primarily affects the lungs, but can also affect other parts of the body. Symptoms include coughing, chest pain, fever, and weight loss. TB is spread through the air when an infected person coughs, sneezes, or talks. It is treated with a combination of antibiotics for a period of several months. Tuberculosis is one of the most serious health issues of the world which is associated with antitubercular drug resistance. Methods: Sputum was collected from presumptive TB patients, those who attended OPD of nine BPHC of Kamrup district, Assam and determined the drug susceptibility of Mycobacterium tuberculosis isolated from sputum positive patients with freshly diagnosed pulmonary TB by using ZN microscope. and DST (culture independent). Results: Out of 199, sputum of 85 number of TB patients were subjected to GeneXpert and LPA. It was observed that, 20% and 6% samples were resistant to the antibiotics rifampicin and Isoniazid respectively. Moreover, multidrug resistance pattern was also observed. 21.17% were found to be both rifampicin and isoniazid resistant, 1.17% Rifampicin and Isoniazid and levofloxacin resistant, 1.17% were rifampicin, levofloxacin and moxifloxacin resistant, again another 1.17% Rifampicin and Levofloxacin resistant. Conclusion: The study highlights the burden of antitubercular drug resistance and established that need of DST in the affected area.
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