Malaria: An Insight into Its Biology, Pathogenesis, Limitation and Opportunities associated with current therapy of Malaria.
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Abstract
The malaria disease is caused by five species of unicellular eukaryotic Plasmodium parasite that are spread by Anopheles mosquito’s bite. It remains one of the serious life- threatening infectious disease and causing millions of deaths in 2021. Malaria is controlled with the combination of vector control methods and medications for both treatment as well as prevention. The prevalent utilization of artemisinin-based polytherapy has attributed to significant reductions in malaria deaths, but drug resistance poses threat to overturn this advancement. Understanding the fundamental biological pathways of disease pathogenesis has aided the development of new medicines, insecticides and diagnostics. Several new combination therapy as well as new compounds with effective against medicine resistible plasmodium and their potential to be employed in mono-dose regimens to increase adherence are in clinical trial. This optimistic malaria-eradication programme includes novel strategies that could result in malaria vaccine or vector controlling strategies. However, despite these accomplishments, malaria elimination will require a well-coordinated global initiative on multiple fronts.
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References
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