Pemphigus Vulgaris : Oral and Skin Manifestations

Article Sidebar

PDF
Published: Mar 23, 2023
Keywords:
Pemphigus vulgaris oral skin vesiculobullous lesion

Main Article Content

Wasim Kamate
Senior Lecturer, Dept. of Oral Pathology, and Microbiology, School of Dental Sciences, Krishna Vishwa Vidyapeeth, Karad, Dist.: Satara; Maharashtra
Nupura Vibhute
Professor and Head of Department Dept. of Oral Pathology and Microbiology, School of Dental Sciences, Krishna Vishwa Vidyapeeth, Karad, Dist.: Satara; Maharashtra
Uzma Belgaumi
Reader, Dept. of Oral Pathology and Microbiology, School of Dental Sciences, Krishna Vishwa Vidyapeeth, Karad, Dist.: Satara; Maharashtra
Vidya Kadashetti
Reader, Dept. of Oral Pathology and Microbiology, School of Dental Sciences, Krishna Vishwa Vidyapeeth, Karad, Dist.: Satara; Maharashtra

Abstract

Pemphigus vulgaris is the most common blistering disease of oral mucosa and skin. Itcomprises of group of autoimmune diseases where antibodies are targeted towards self-antigen particularly of desmoglein family (Dsg 3 and Dsg1) of desmosomal junctions.


Autoantibodies of IgG class are targeted against these desmosomal junctions. Thisreview gives an overview of important characteristic features of Pemphigus vulgaris withits various oral and skin manifestations.

Article Details

How to Cite
Kamate, W. ., Vibhute, N. . ., Belgaumi, U. ., & Kadashetti, V. . (2023). Pemphigus Vulgaris : Oral and Skin Manifestations. Journal of Coastal Life Medicine, 11(1), 1234–1237. Retrieved from https://www.jclmm.com/index.php/journal/article/view/499
Issue
Vol. 11: Number 1, 2023
Section
Articles

References

Neville BW.;Damm DD.; Allen CM, Bouquot, JE. Oral &Maxillofacial Pathology. 3rd ed. St. Louis, Saunders Elsevier, 2009.

Deuter M, Turnbull J. Advanced Oxford Dictionary. 8th edition. Oxford university press. 9th edition. 2014.

Walker HK, Hall WD, Hurst JW. Clinical methods: The history, physical and laboratory examinations. 3 rd ed. Boston: Butterworths; 1990. p101-18.

Suran LF, Jamma Li, Schifter M (2013). Pemphigus Vulgaris and Pemphigus Foliaceus, Skin Biopsy - Diagnosis and Treatment, Prof. Suran Fernando (Ed.), InTech, DOI: 10.5772/56423. Available from:http://www.intechopen.com/books/skin-biopsy-diagnosis-and treatment/pemphigus-vulgaris-and-pemphigus-foliaceus

Scully C, Challacombe S. Pemphigus vulgaris: update on etiopathogenesis,Oralmanifestations, and management. Crit Rev Oral Biol Med 2002;13(5):397-408

Fellner MJ, Sapadin AN. Current therapy of pemphigus vulgaris. Mt Sinai J Med.2001; 68(4-5):268–78.

Thivolet J, Jablonska S. Bullous disorders: from histology to molecular biology. ClinDermatol2001; 19(5):538–43.

Turr E, Brenner S. Diet and pemphigus in pursuit of exogenous factors in pemphigus andfogo selvage. Arch Dermat. 1998; 134:1406-1410.

Ben Lagha N, Poulesquen V, Roujeau JC, Alantar A, Maman L. Pemphigus vulgaris: a case-based update. J Can Dent Assoc. 2005;71(9):667-72.

Lever WF, Schaumburg-Lever G. Treatment of pemphigus vulgaris. Results obtained in 84 patients between 1961 and 1982. Arch Dermatol1984;120(1):44–47.

Ruocco E, Baroni A, Wolf R, Ruocco V. Life-threatening bullous dermatoses: Pemphigus vulgaris. ClinDermatol. 2005; 23: 223-26.

Gumbiner BM, McCrea PD. Catenins as mediators of the cytoplasmic functions of cadherins. J Cell Sci Suppl. 1993;17:155-58.

Bhol K, Natarajan K, Nagarwalla N, Mohimen A, Aoki V, Ahmed AR. Correlation of peptide specificity and IgG subclass with pathogenic and nonpathogenic autoantibodies in pemphigus vulgaris: a model for autoimmunity. Proc Natl Acad Sci. 1995;92:5239-43.

Hertl M. Humoral and Cellular Autoimmunity in Autoimmune Bullous Skin Disorders. Int Arch Allergy Immunol. 2000;122:91-100.

Gniadecki R. Desmoglein autoimmunity in the pathogenesis of pemphigus. Autoimmunity. 2006;39:541-47.

Weinberg MA, Insler MS, Campen RB. Mucocutaneous features of autoimmune blistering diseases. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 1997;84(5):517-34.

Stanley JR, Koulu L, Thivolet C. Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies. J Clin Invest 1984;74:313-20.

Vaillant L. [Bullous autoimmune diseases of the oral mucosa]. Rev StomatolChirMaxillofac1999; 100(5):230–9.

Laskaris G, Satriano RA. Drug-induced blistering oral lesions. ClinDermatol1993;11:545-50.

Nikitakis N.Oral soft tissue lesions: A guide to differential diagnosis Part II: Surface alterations. Braz J Oral Sci. 2005; 4(13):707-15.

Shamim T, Varghese VI, Shameena PM, Sudha S. Pemphigus vulgaris in oral cavity: clinical analysis of 71 cases. Med Oral Patol Oral Cir Bucal. 2008; 13: 622-26

Shamimul Hasan et al. Pemphigus vulgaris: an insight on conventional and emerging treatment modalities. Int. Res. J. Pharm. 2013, 4 (3):8-12.

Femiano F, Gombos F, Nunziata M, Esposito V, Scully C. Pemphigus mimicking apthous stomatitis. J. Oral path. Med. 2005; 34; 508 – 10.

Shklar G, Frim S, Flynn E. Gingival lesions of pemphigus. J of Periodontology. 1978; 49:428-35.

Bystryn JC, Rudolph JL. Pemphigus. Lancet. 2005;366(9479):61-73.

Mourellou O, Chaidemenos GC, Koussidou T, Kapetis E. The treatment of pemphigus vulgaris. Experience with 48 patients seen over an 11-year period. Br J Dermatol. 1995;133:83-7.