Formulation and Evaluation of Skin Alleviating Suntan SLN Lotion of Herbal Extracts

Main Article Content

Sonam Bendre
Revan Karodi
Revan Karodi
Shubham Dange
Shital Rajad

Abstract

Natural plant extracts have recently been regarded as viable sunscreen resources due to their strong UV radiation absorption and antioxidant activity. In order to lessen the risk of skin cancer, herbal suntan lotion works to shield the skin from the sun's ultraviolet rays. This lowers the chance of skin damage. Because it has anti-inflammatory, antioxidant, and wound-healing characteristics, the Carica papaya L. (Caricaceae) and mulberry (Moraceae) extract is beneficial for the skin. The goal is to create an SLN lotion that increases the medicinal effectiveness, bioavailability, and stability of plant ingredients as well as activities such as whitening, acne control, and anti-aging. The melt dispersion ultrasonication method was used to create a solid lipid nanoparticle lotion with Carica papaya and mulberry extracts, and several combinations recommended by the design expert were created. As a result, mulberry and papaya extract can be used to create cosmetic formulations with depigmenting activity. The sunscreen creams were tested for stability, safety, and SPF using three distinct compositions: F1, F2, and F3. The sunscreen lotions were found to be non-mutagenic, non-irritant, stable, and to have SPF for normal skin, and the batch with the best results was compared to the commercial formulation.

Article Details

How to Cite
Sonam Bendre, Revan Karodi, Revan Karodi, Shubham Dange, & Shital Rajad. (2023). Formulation and Evaluation of Skin Alleviating Suntan SLN Lotion of Herbal Extracts. Journal of Coastal Life Medicine, 11(1), 1691–1712. Retrieved from https://www.jclmm.com/index.php/journal/article/view/574
Section
Articles

References

Rasheed, A., Shama, S. N., Mohanalakshmi, S., & Ravichandran, V. (2012). Formulation, characterization and in vitro evaluation of herbal sunscreen lotion. Oriental Pharmacy and Experimental Medicine, 12(4), 241-246.

Donglikar, M. M., & Deore, S. L. (2017). Development and evaluation of herbal sunscreen. Pharmacognosy Journal, 9(1).

Burger, P., Landreau, A., Azoulay, S., Michel, T., & Fernandez, X. (2016). Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners. Cosmetics, 3(4), 36.

Hanif, N., Al-Shami, A., Khalid, K., & Hadi, H. (2020). Plant-based skin lightening agents: A review. The Journal Of Phytopharmacology, 9(1), 54-60.

Seo, S., Ngo,H., Hwang,E., Park, B., Yi,T . (2020). Protective effects of Carica papaya leaf against skin photodamage by blocking production of matrix metalloproteinases and collagen degradation in UVB-irradiated normal human dermal fibroblasts, South African Journal of Botany, 131, 398-405.

Kumar ,M., Swarnkar, S., Sharma, V., Baldi, S., Ashish. (2012). Herbal Cosmetics: Used for Skin and Hair. Inventi Rapid Cosmeceuticals, 1-7.

Asmah R, M., (2014). Proximate Analysis, Antioxidant and Anti Proliferative Activities of Different Parts of Carica papaya. Journal of Tissue Science & Engineering, 5(01)

Wissing, S. (2003). Cosmetic applications for solid lipid nanoparticles (SLN). International Journal Of Pharmaceutics, 254(1), 65-68.

Nageen, A., Shilpi, A., Murthy, R. (2012). Latest Technology Advances in Cosmaceuticals. Int. J. Pharm. Sci. Drug Research , 4.

Le, N., Cao, V., Nguyen, T., Le, T., Tran, T. and Hoang Thi, T.(2019). Soy Lecithin-Derived Liposomal Delivery Systems: Surface Modification and Current Applications. International Journal of Molecular Sciences, 20(19), 4706

Yu, Y., Yang, X., Wu, X. and Fan, Y.( 2021). Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications. Frontiers in Bioengineering and Biotechnology, 9.

Duan, Y., Dhar, A., Patel, C., Khimani, M., Neogi, S., Sharma, P., Siva Kumar, N. and Vekariya, R.(2020). A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems. RSC Advances, 10(45), 26777-26791.

Sharma, A., Sharma, R., Sharma, M., Kumar, M., Barbhai, M. D., Lorenzo, J. M., ... & Mekhemar, M. (2022). Carica papaya L. Leaves: Deciphering Its Antioxidant Bioactives, Biological Activities, Innovative Products, and Safety Aspects. Oxidative Medicine and Cellular Longevity, 2022.

Omidiwura, B. R. O. (2017). Qualitative and quantitative analysis of pawpaw (Carica papaya) leaf extract and its antimicrobial effect in animal production. Nigerian Journal of Animal Production, 44(3), 76-83.

Singh, P., Tanwar, N., Saha, T., Gupta, A., & Verma, S. (2018). Phytochemical screening and analysis of Carica papaya, Agave americana and Piper nigrum. Int J Curr Microbiol Appl Sci, 7(2), 1786-1794.

Iyer, D., Sharma, B. K., & Patil, U. K. (2011). Effect of ether-and water-soluble fractions of Carica papaya ethanol extract in experimentally induced hyperlipidemia in rats. Pharmaceutical biology, 49(12), 1306-1310.

Singh, P., Tanwar, N., Saha, T., Gupta, A., & Verma, S. (2018). Phytochemical screening and analysis of Carica papaya, Agave americana and Piper nigrum. Int J Curr Microbiol Appl Sci, 7(2), 1786-1794

Palanisamy, P. R. A. D. E. E. P., & Basalingappa, K. M. (2020). Phytochemical analysis and antioxidant properties of leaf extracts of Carica papaya. Phytochemical Analysis, 13(11), 58-62.

De, S., Rr, L., Vabeiryureilai, M., Senthil, N., & Lalnunmawii, E. (2015). An investigation of the antioxidant property of Carica papaya leaf extracts from Mizoram, Northeast India. Research & Reviews: Journal of BotanicalSciences.

50 Ramesh, H & Venkataramegowda, Sivaram & Murthy,. (2014). Antioxidant and Medicinal properties of Mulberry (Morus sp.): A Review. World Journal of Phramaceutical Reserach Research ,3, 320-343.

Vuong, Q. V., Hirun, S., Roach, P. D., Bowyer, M. C., Phillips, P. A., & Scarlett, C. J. (2013). Effect of extraction conditions on total phenolic compounds and antioxidant activities of Carica papaya leaf aqueous extracts. Journal of herbal medicine, 3(3), 104-111.

Hu, L., Wang, C., Guo, X., Chen, D., Zhou, W., Chen, X. and Zhang, Q. (2021). Flavonoid Levels and Antioxidant Capacity of Mulberry Leaves: Effects of Growth Period and Drying Methods. Frontiers in Plant Science, 12.

Sánchez-Salcedo, E., Mena, P., García-Viguera, C., Hernández, F. and Martínez, J.(2015). (Poly)phenolic compounds and antioxidant activity of white (Morus alba) and black (Morus nigra) mulberry leaves: Their potential for new products rich in phytochemicals. Journal of Functional Foods, 18, 1039-1046.

Shinde, Devanand & Chavan, Machindra & Wakte, Pravin. (2011). HPTLC in herbal drug quantification. High-Performance Thin-Layer Chromatography (HPTLC).

Shivatare, Rakesh & Nagore, Dheeraj & Nipanikar, Sanjay. (2013). 'HPTLC' an important tool in standardization of herbal medical product: A review. 2. 1086-1096.

Sangeetha, R., Ravi, T., Sudhakaran, T., et al . (2020). Estimation of Tannic Acid by RP-HPLC and Gallic Acid by HPTLC Method in the Methanolic Extract of Carica papaya Linn. Leaves and its Formulation. Der Pharmacia Lettre, 12, 1-18.

Bunaciu, Andrei A. & Aboul-Enein, Hassan & Fleschin, Serban. (2011). Recent Applications of Fourier Transform Infrared Spectrophotometry in Herbal Medicine Analysis. Applied Spectroscopy Reviews. 46. 251-260

Nugraha, M., Iswandana, R., & Jufri, M. (2020). Preparation, Characterization, And Formulation Of Solid Lipid Nanoparticles Lotion From Mulberry Roots (Morus Alba L.). International Journal Of Applied Pharmaceutics, 182-186.

Sastri, K. T., Radha, G. V., Pidikiti, S., & Vajjhala, P. (2020). Solid lipid nanoparticles: Preparation techniques, their characterization, and an update on recent studies. Journal of Applied Pharmaceutical Science, 10(6), 126-141.

Saptarini, N., & Hadisoebroto, G. (2020). Formulation And Evaluation Of Lotion And Cream Of Nanosized Chitosan-Mangosteen (Garcinia Mangostana L.) Pericarp Extract. Rasayan Journal Of Chemistry, 13(02), 789-795.

Vijapur, L. S., Desai, A. R., & Shidramshettar, S. Formulation, Characterization and In-vitro Evaluation of Herbal Sunscreen Gel Containing Anthocyanin.

Arora, S., Sharma, N., Mahajan, A., Kaur, J., & Singh, S. (2015). Development, physicochemical characterization and in-vitro evaluation of herbal sunscreen lotion. Journal of Pharmaceutical Technology, Research and Management, 3(2), 113-125.

Sayre, R.M. Agin, P.P. Levee, G.J. and Marlowe, E. (1979) A Comparison of in-vivo and in-vitro testing of sun screening formulas. Photochem and Photobio, 29, 559-566.