Iontophoresis in Dentistry: A Review

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Akshay Verma
Abhishek Choudhary
Shubhangi Pareek
Shreeyam Mohapatra
Abhishek Sharma
Romil Sharma


Systemic and local drug administrations are the two basic classifications for drug delivery in the oral cavity. Efficient drug delivery in the oral cavity is necessary for the treatment of oral illnesses in both soft and hard oral tissues (e.g., mucosal and enamel, respectively). Improved local and systemic medicine administration is made possible by the non-invasive technology known as iontophoresis (IP). Iontophoresis was primarily researched for transbuccal medication administration in the oral cavity. For various drugs, buccal iontophoresis significantly improved drug delivery when compared to passive transport. For the purpose of treating oral problems locally in the oral cavity, iontophoresis can improve drug penetration into the oral tissues. Iontophoresis has been tested for use in dentistry to cure hypersensitivity as well as to create local anaesthesia.

Introduction: Iontophoresis has become one of the most promising tools for transdermal medication delivery among recent discoveries. A direct electrical current is used to introduce ions into the bodily tissues during iontophoresis, a therapeutic procedure.1 It was first developed by LeDuc in 1903 as a method of transferring molecules over a membrane using an electrical current as the driving force. It was first known as ion transfer. Iontophoresis has undergone a variety of uses and popularity trends since that time.2 Iontophoresis has recently received more attention and is now a frequently employed clinical treatment. Iontophoresis is a painless, sterile, noninvasive method for introducing particular ions into a tissue that has been shown to have a beneficial impact on the healing process. This method has various advantages over other conventional  methods.Iontophoresis is a simple and effective method that enhances local and systemic medicine delivery by using an electric field. In the oral cavity, transbuccal medicine administration was the main focus of iontophoresis research. When compared to passive transport, buccal iontophoresis greatly improved medication delivery for a number of different medicines. For local drug administration in the oral mucosa to treat oral problems, iontophoresis may enhance drug penetration into oral tissues. Iontophoresis has been testing to determine whether it may be used in dentistry to treat hypersensitivity and produce local anaesthetic.4 Aim of present review of literature is to discuss application of Iontophoresis in Dentistry.

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Verma, A. ., Choudhary, A. ., Pareek, S. ., Mohapatra, S. ., Sharma, A. ., & Sharma, R. . (2023). Iontophoresis in Dentistry: A Review. Journal of Coastal Life Medicine, 11(1), 1777–1782. Retrieved from


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