Iontophoresis in Dentistry: A Review

Main Article Content

Akshay Verma
Abhishek Choudhary
Shubhangi Pareek
Shreeyam Mohapatra
Abhishek Sharma
Romil Sharma

Abstract

Systemic and local drug administrations are the two basic classifications for drug delivery in the oral cavity. Efficient drug delivery in the oral cavity is necessary for the treatment of oral illnesses in both soft and hard oral tissues (e.g., mucosal and enamel, respectively). Improved local and systemic medicine administration is made possible by the non-invasive technology known as iontophoresis (IP). Iontophoresis was primarily researched for transbuccal medication administration in the oral cavity. For various drugs, buccal iontophoresis significantly improved drug delivery when compared to passive transport. For the purpose of treating oral problems locally in the oral cavity, iontophoresis can improve drug penetration into the oral tissues. Iontophoresis has been tested for use in dentistry to cure hypersensitivity as well as to create local anaesthesia.


Introduction: Iontophoresis has become one of the most promising tools for transdermal medication delivery among recent discoveries. A direct electrical current is used to introduce ions into the bodily tissues during iontophoresis, a therapeutic procedure.1 It was first developed by LeDuc in 1903 as a method of transferring molecules over a membrane using an electrical current as the driving force. It was first known as ion transfer. Iontophoresis has undergone a variety of uses and popularity trends since that time.2 Iontophoresis has recently received more attention and is now a frequently employed clinical treatment. Iontophoresis is a painless, sterile, noninvasive method for introducing particular ions into a tissue that has been shown to have a beneficial impact on the healing process. This method has various advantages over other conventional  methods.Iontophoresis is a simple and effective method that enhances local and systemic medicine delivery by using an electric field. In the oral cavity, transbuccal medicine administration was the main focus of iontophoresis research. When compared to passive transport, buccal iontophoresis greatly improved medication delivery for a number of different medicines. For local drug administration in the oral mucosa to treat oral problems, iontophoresis may enhance drug penetration into oral tissues. Iontophoresis has been testing to determine whether it may be used in dentistry to treat hypersensitivity and produce local anaesthetic.4 Aim of present review of literature is to discuss application of Iontophoresis in Dentistry.

Article Details

How to Cite
Verma, A. ., Choudhary, A. ., Pareek, S. ., Mohapatra, S. ., Sharma, A. ., & Sharma, R. . (2023). Iontophoresis in Dentistry: A Review. Journal of Coastal Life Medicine, 11(1), 1777–1782. Retrieved from https://www.jclmm.com/index.php/journal/article/view/587
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References

Semalty A, Semalty M, Singh R, Saraf SK, Saraf S. Iontophoretic drug delivery system: a review. Technol Health Care. 2007;15(4):237-245.

Rawat S, Vengurlekar S, Rakesh B, Jain S, Srikarti G. Transdermal delivery by iontophoresis. Indian J Pharm Sci. 2008 Jan;70(1):5-10. doi: 10.4103/0250-474X.40324. PMID: 20390073; PMCID: PMC2852061.

Batheja P, Thakur R, Michniak B. Transdermal iontophoresis [published correction appears in Expert Opin Drug Deliv. 2006 Mar;3(2):303.

Wanasathop A, Li SK. Iontophoretic Drug Delivery in the Oral Cavity. Pharmaceutics. 2018; 10(3):121. https://doi.org/10.3390/pharmaceutics10030121

Ragit R, Fulzele P, Rathi N V, et al. (October 25, 2022) Iontophoresis as an Effective Drug Delivery System in Dentistry: A Review. Cureus 14(10): e30658. DOI 10.7759/cureus.30658

Arowojolu MO: Fluoride iontophoresis versus topical fluoride application in the treatment of dentine hypersensitivity. Niger J Clin Pract. 2002, 5:87-90. 10.4314/njcp.v5i2.11117

Kalia YN, Naik A, Garrison J, Guy RH: Iontophoretic drug delivery. Adv Drug Deliv Rev. 2004, 56:619-58. 10.1016/j.addr.2003.10.026

Pikal MJ: The role of electroosmotic flow in transdermal iontophoresis . Adv Drug Deliv Rev. 2001, 46:281- 305. 10.1016/s0169-409x(00)00138-1

Costello CT, Jeske AH: Iontophoresis: applications in transdermal medication delivery . Phys Ther. 1995, 75:554-63. 10.1093/ptj/75.6.554

Becker SM, Kuznetsov AV: Transport In Biological Media. Elsevier, Oxford; 2013. 10.1016/C2011-0-05837-4

Rai R, Srinivas CR: Iontophoresis in dermatology. Indian J Dermatol Venereol Leprol. 2005, 71:236-41. 10.4103/0378-6323.16613

Karpiński TM: Selected medicines used in iontophoresis . Pharmaceutics. 2018, 10:204.

Fang JY, Hung CF, Wong WW. Skin Pharmacol Physiol 2006; 19:28-37.

Abramowitz D, Neoussikine B. Treatment by Ion Transfer, New York: Grune and Stratton; 1946. p. 87.

Schriber WJ, editor. A manual of electrotherapy, 4th ed., Philadelphia: Lea and Febiger; 1975. p. 125-31

Siddiqui O, Roberts MS, Polock AZ. The effect of iontophoresis and vehicle pH on the in-vitro permeation of lignocaine through human stratum corneum. J Pharm Pharmacol 1985;37:732-5.

Abramson HA, Alley A. Mechanisms of histamine iontophoresis from aqueous media. Arch Phys Ther 1937;18:327

Pikal MJ, Shah S. Transport mechanisms in iontophoresis II. Electroosmotic flow and transference number measurement for hairless mouse skin. Pharm Res 1990;7:313-21.

Meechan JG. Intra-oral topical anaesthetics: a review. J Dent 2000;28(1):3–14. DOI: 10.1016/s0300-5712(99)00041-x.

Thongkukiatkun W, Vongsavan K, Kraivaphan P, et al. Effects of the iontophoresis of lignocaine with epinephrine into exposed dentine on the sensitivity of the dentine in man. Arch Oral Biol 2015;60(8):1098–1103. DOI: 10.1016/j.archoralbio.2015. 04.006.

Cubayachi C, Couto ROD, de Gaitani CM, et al. Needle-free buccal anesthesia using iontophoresis and amino amide salts combined in a mucoadhesive formulation. Colloids Surf B Biointerfa 2015;136:1193– 1201. DOI: 10.1016/j.colsurfb.2015.11.005

American Academy of Periodontology. Glossary of periodontal Terms (2001).

Sandhu SP, Sharma RL, Bharti V. Comparative evaluation of different strengths of electrical current in the management of dentinal hypersensitivity. Indian Journal of Dental Research. 2010 ;21(2):207-12

Sethi R, Indurkar MS. Comparison of Fluoride Iontophoresis and Dentin Bonding Agent Application in the Treatment of Dentin Hypersensitivity: A clinical study. Indian J Dent Adv. 2015; 7(1):13-7.

Arowojolu MO. Fluoride Iontophoresis Versus Topical Fluoride Application in the treatment of Dentine Hypersensitivity. Nigerian Journal of clinical practice. 2002 Dec;5(2):87-90.

Kaur M. Methyl Prednisolone with Iontophoresis in the Treatment of Dentine Hypersensitivity. An In-Vitro and In-Vivo Study. IOSR Journal of Dental and Medical Sciences (IOSRJDMS). 2016;15(2):52-60.

Gergova RT, Gueorgieva T, Dencheva-Garova MS, Krasteva-Panova AZ, Kalchinov V, Mitov I, Kamenoff J: Antimicrobial activity of different disinfection methods against biofilms in root canals . J Investig Clin Dent. 2016, 7:254-62. 10.1111/jicd.12147

ST EC, TA JB: Influence of electrical potential on ion migration in teeth. 2. Quantitative measurements of I-131 penetration by an acid-leaching technique. J Dent Res. 1964, 43:175-86. 10.1177/00220345640430020401

Shirwaiker RA, Wysk RA, Kariyawasam S, Voigt RC, Carrion H, Nembhard HB: Interdigitated silver-polymerbased antibacterial surface system activated by oligodynamic iontophoresis - an empirical characterization study. Biomed Microdevices. 2014, 16:1-10. 10.1007/s10544-013-9800-x2122.

Lee YE, Baek HJ, Choi YH, Jeong SH, Park YD, Song KB: Comparison of remineralization effect of three opical fluoride regimens on enamel initial carious lesions. J Dent. 2010, 38:166-71.

Roustit M, Blaise S, Cracowski JL. Trials and tribulations of skin iontophoresis in therapeutics. Br J Clin Pharmacol. 2014;77(1):63-71. doi:10.1111/bcp.12128.