Overview of the Biological Activities of Quinazolines
Main Article Content
Quinazoline is a renowned and significant heterocyclic molecule containing nitrogen atom with the chemical formula C8H6N2, and numerous techniques for their synthesis have been developed. Due to its numerous applications, quinazoline, which is composed of two six-membered hetero aromatic rings one is benzene and second one is pyrimidine. Quinazoline derivatives were found to be a versatile molecules and exhibit a broad range of pharmacological activities which made interest to this area of study. Quinazolines and their derivatives are among the most pharmacologically potent compounds, with variety of biological activities and proved an activity against to an infectious diseases such as malaria and tuberculsois, inflammation, cancer, and hypertension. They also act as anti convulsant. Quinazoline posses mild to moderate anti bacterial and ani fungal activity.When quinazoline fused with pyrazoline leads to the formation of potent analgesics.Some phenyl quinazoline derivatives have showed greater anti inflammatory activity even than indomethacin. Benzimidazo quinazolines proved an effective anti cancer agents.If smaller alkoxy groups such as methoxy groups attached to quinazoline nucleus led to the development of new leads for an antihypertensive activity. Development of novel dihydro benzo(h)quinazolines were proved as an effective anti retro viral molecules.The derivatives of dichloro quinazolines showed an excellent anti convulsant activiy.Development of 2,3- di substitited quinazolinones have prepared and studied their antiplasmodiall activity. Study of anti tubercular activity of 2-trichloro methyl quinazolines reveals that this moiety may also serve as potent leads for anti tubercular activity.The overall intention of this review is to seeks the attention of researchers to explore medicinal and biological importance of quinazoline nucleus.
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