Formulation & Evaluation of Meletin Microspheres

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Kishor Dholwani
Bharat Vashistha
Zankhana Pramodchandra Sheth
Rajesh Dodiya
Vaishnav Sonal Hiralal
Divya Niranjan
Saurabh Sharma


An organoleptic property of the API is identified in this study, and it appears to be a yellow, tasteless, and odorless powder. It was found to be freely soluble in DMSO and other solvents, and its melting point was determined to be 333.20 C. Meletine in hydroalcholic solution's standard curve was drawn at 370 nm using various aliquots; the regression coefficient was r2=0.981. The API and polymer mixture was then subjected to an interaction study, and it was determined to be compatible, indicating that there was no interaction. Following first-order kinetics, the release study of various batches was conducted at various time intervals. The percentage of cumm. release was calculated by release of API at two hundred ten  minutes to be hundred percent API release. The chart is plotted between percent total delivery verses time and a semi log diagram is plotted between log percentage combined discharge verses time. Finally, the mucoadhesive strength of the various batches was measured, and batch F6 had the highest mucoadhesion. As a result, Meletine can be made into a mucoadhesive microsphere that can be used as an antidote to Toxic gases for sustained release, defense of the mucosa lining, and in the event of accident.

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Dholwani, K. ., Vashistha, B. ., Sheth, Z. P. ., Dodiya, R. ., Hiralal, V. S. ., Niranjan, D. ., & Sharma, S. . (2023). Formulation & Evaluation of Meletin Microspheres. Journal of Coastal Life Medicine, 11(1), 1909–1917. Retrieved from


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