Water Qualification in Pharmaceutical Industry

Main Article Content

Sneha.H
Yashwanth.C.P
Kiran kumar Desai
Praveen Halagali
H V Gangadharappa

Abstract

Water is a critical component in the manufacturing process of pharmaceuticals. The quality of water used in pharmaceuticals can have a significant impact on product quality, efficacy, and patient safety. Therefore, it is essential to ensure that the water used in pharmaceutical manufacturing meets the required standards. This article provides an overview of the water qualification process in the pharmaceutical industry, including the different types of water used and the standards that must be met. The article also highlights the various techniques used to qualify water, such as physical, chemical, and microbiological testing. Additionally, the article discusses the critical role of validation in the water qualification process, including the need for ongoing monitoring to ensure water quality remains within acceptable limits. Finally, the article emphasizes the importance of a robust water management system, including maintenance and control procedures, to ensure water quality is maintained throughout the pharmaceutical manufacturing process. Overall, this article emphasizes the importance of water qualification in the pharmaceutical industry and highlights the measures necessary to ensure the quality of water used in pharmaceutical manufacturing.

Article Details

How to Cite
Sneha.H, Yashwanth.C.P, Kiran kumar Desai, Praveen Halagali, & H V Gangadharappa. (2023). Water Qualification in Pharmaceutical Industry. Journal of Coastal Life Medicine, 11(1), 1918–1932. Retrieved from https://www.jclmm.com/index.php/journal/article/view/608
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Articles

References

Kelly M, Bennett C, Coste M, Delgado C, Delmas F, Denys L, et al. A comparison of national approaches to setting ecological status boundaries in phytobenthos assessment for the European Water Framework Directive: results of an intercalibration exercise. Hydrobiologia. 2009;621(1):169–82.

General Chapters: <1231> WATER FOR PHARMACEUTICAL PURPOSES [Internet]. [cited 2023 Mar 6]. Available from: http://pharmacopeia.cn/v29240/usp29nf24s0_c1231.html

Muroi M, Sasaki T, Urayama Y, Katayama H, Yakuhin B, Kokubo LM, et al. Guidance on the Manufacture of Sterile Pharmaceutical Products by Aseptic Processing Pharmaceuticals and Medical Devices Agency: Guidance on the Manufacture of Sterile Pharmaceutical Products by Aseptic Processing.

Microbiological Quality Considerations in Non-sterile Drug Manufacturing Guidance for Industry DRAFT GUIDANCE. [cited 2023 Mar 8]; Available from: https://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm

Haigney S. What Goes Wrong When API Quality is Compromised? Pharmaceutical Technology [Internet]. 2022 [cited 2023 Mar 8];46(8):16–9. Available from: https://www.pharmtech.com/view/what-goes-wrong-when-api-quality-is-compromised-

Szilágyi F, Ács É, Borics G, Halasi-Kovács B, Juhász P, Kiss B, et al. Application of water framework directive in Hungary: development of biological classification systems. Water Science and Technology. 2008;58(11):2117–25.

What are the differences between Purified Water (PW) and Water for Injection (WFI)? - AQUA-CHEM [Internet]. [cited 2023 Mar 6]. Available from: https://aqua-chem.com/difference_purified_water_pw_water_for_injection_wfi/

Medicines Agency E. Committee for Medicinal Products for Human Use (CHMP) Committee for Medicinal Products for Veterinary Use (CVMP) Guideline on the quality of water for pharmaceutical use. 2020 [cited 2023 Mar 8]; Available from: www.ema.europa.eu/contact

(PDF) Water for Pharmaceutical Uses: Quality control and validation [Internet]. [cited 2023 Mar 6]. Available from: https://www.researchgate.net/publication/259081307_Water_for_Pharmaceutical_Uses_Quality_control_and_validation

Nassiri Koopaei N, Abdollahi M. Health risks associated with the pharmaceuticals in wastewater. DARU Journal of Pharmaceutical Sciences [Internet]. 2017 Apr 12 [cited 2023 Mar 6];25(1). Available from: /pmc/articles/PMC5389172/

Types of water in pharmaceutical Pharmaguddu [Internet]. [cited 2023 Mar 8]. Available from: https://pharmaguddu.com/types-water-pharmaceutical/

Types of Water used in Pharmaceutical Processes : Pharmaguideline [Internet]. [cited 2023 Mar 8]. Available from: https://www.pharmaguideline.com/2011/12/types-of-water-used-in-pharmaceutical.html

Design & Control of Pharma Water System to Minimize Microbiological Contamination | Pharmaceutical Engineering [Internet]. [cited 2023 Mar 8]. Available from: https://ispe.org/pharmaceutical-engineering/july-august-2017/design-control-pharma-water-system-minimize

Microbiological monitoring of pharmaceutical water systems [Internet]. [cited 2023 Mar 8]. Available from: https://www.europeanpharmaceuticalreview.com/article/77414/microbiological-monitoring-of-pharmaceutical-water-systems/

General Chapters: <1231> WATER FOR PHARMACEUTICAL PURPOSES [Internet]. [cited 2023 Mar 8]. Available from: http://www.uspbpep.com/usp29/v29240/usp29nf24s0_c1231.html

Pharmaceutical Water : Pharmaguideline [Internet]. [cited 2023 Mar 6]. Available from: https://www.pharmaguideline.com/2012/09/pharmaceutical-water.html

Pharmaceutical Residues in Freshwater Hazards and Policy Responses Pharmaceutical Residues in Freshwater Hazards and Policy Responses Contents.

Strade E, Kalnina D, Kulczycka J. Water efficiency and safe re-use of different grades of water - Topical issues for the pharmaceutical industry. Water Resour Ind. 2020 Dec 1;24:100132.

Patel M, Kumar R, Kishor K, Mlsna T, Pittman CU, Mohan D. Pharmaceuticals of emerging concern in aquatic systems: Chemistry, occurrence, effects, and removal methods. Chem Rev [Internet]. 2019 Mar 27 [cited 2023 Mar 8];119(6):3510–673. Available from: https://pubs.acs.org/doi/full/10.1021/acs.chemrev.8b00299

Annex 1 WHO good practices for pharmaceutical quality control laboratories.

Water in Pharma – All About Drugs [Internet]. [cited 2023 Mar 8]. Available from: https://www.allfordrugs.com/water-in-pharma/

QUALITY OF WATER FOR PHARMACEUTICAL USE: AN OVERVIEW | PharmaTutor [Internet]. [cited 2023 Mar 8]. Available from: https://www.pharmatutor.org/articles/quality-of-water-for-pharmaceutical-use-an-overview

Water for Pharmaceutical Use | FDA [Internet]. [cited 2023 Mar 6]. Available from: https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/inspection-technical-guides/water-pharmaceutical-use

Coulliette AD, Arduino MJ. Hemodialysis and Water Quality. Semin Dial [Internet]. 2013 Jul [cited 2023 Mar 6];26(4):427. Available from: /pmc/articles/PMC4596525/

Pharmaceutical Water : Pharmaguideline [Internet]. [cited 2023 Mar 8]. Available from: https://www.pharmaguideline.com/2012/09/pharmaceutical-water.html

WATER FOR PHARMACEUTICAL PURPOSES - PharmaState Academy [Internet]. [cited 2023 Mar 8]. Available from: https://pharmastate.academy/water-for-pharmaceutical-purposes/

Annex 2 WHO good manufacturing practices: water for pharmaceutical use 1.

Rutala WA, Weber DJ. Disinfection, Sterilization, and Control of Hospital Waste. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases [Internet]. 2015 Aug 28 [cited 2023 Mar 6];2:3294. Available from: /pmc/articles/PMC7099662/

Toledo Thornton M. Pharmaceutical Waters Guide for Regulatory Compliance, Analysis and Real-Time Release courtesy of Alliance Technical Sales [Internet]. Available from: www.alliancets.com

PHARMACEUTICAL Pure Water Guide.

Sandle T. Assessment of Pharmaceutical Water Systems. Biocontamination Control for Pharmaceuticals and Healthcare. 2019 Jan 1;213–24.

Purified water - Wikipedia [Internet]. [cited 2023 Mar 6]. Available from: https://en.wikipedia.org/wiki/Purified_water

Water for Injection (WFI) | Veolia [Internet]. [cited 2023 Mar 8]. Available from: https://www.veoliawatertech.com/en/expertise/applications/water-injection

METHODS OF PRODUCING WFI - WATER FOR INJECTION [Internet]. [cited 2023 Mar 8]. Available from: https://waterforinjection.com/pharmaceutical-water-for-injection-methods-to-produce-wfi

Preparation Process for Water for Injection (WFI) in Pharmaceuticals : Pharmaguideline [Internet]. [cited 2023 Mar 6]. Available from: https://www.pharmaguideline.com/2017/07/preparation-process-for-water-for-injection.html

Medicines Agency E. Committee for Medicinal Products for Human Use (CHMP) Committee for Medicinal Products for Veterinary Use (CVMP) Guideline on the quality of water for pharmaceutical use. 2020 [cited 2023 Mar 6]; Available from: www.ema.europa.eu/contact

Water for Injection (WFI) [Internet]. [cited 2023 Mar 8]. Available from: https://www.evoqua.com/en/markets/applications/water-for-injection-wfi/

USP42-NF37_221.

What is Water For Injection (WFI)? | Technical Safety Services [Internet]. [cited 2023 Mar 8]. Available from: https://techsafety.com/blog/what-is-water-for-injection

fda, cder. Sterile Water for Injection, USP in VIAFLEX Plastic Container For Drug Diluent Use Only.

Sterile Water for Injection: Package Insert / Prescribing Information - Drugs.com [Internet]. [cited 2023 Mar 6]. Available from: https://www.drugs.com/pro/sterile-water-for-injection.html

fda, cder. Sterile Water for Injection, USP in VIAFLEX Plastic Container For Drug Diluent Use Only.

Water for injection - Wikipedia [Internet]. [cited 2023 Mar 8]. Available from: https://en.wikipedia.org/wiki/Water_for_injection

Organization WHealth. World Health Organization Model Formulary 2008. 2009;645.

PHARMACEUTICAL WATER - PharmaState Academy [Internet]. [cited 2023 Mar 6]. Available from: https://pharmastate.academy/pharmaceutical-water/

Understanding USP Water for Pharmaceutical Use [Internet]. [cited 2023 Mar 8]. Available from: https://www.pharmtech.com/view/understanding-usp-water-pharmaceutical-use

Water for Pharmaceutical Purposes - New USP Requriements [Internet]. [cited 2023 Mar 8]. Available from: https://www.slideshare.net/shettyuc/water-for-pharmaceutical-purposes-new-usp-requriements

Guidelines for Drinking-water Quality FOURTH EDITION INCORPORATING THE FIRST ADDENDUM.

Shintani H. Validation study and quality assurance of pharmaceutical water, waterborne microorganisms and endotoxins. Biocontrol Sci [Internet]. 2016 [cited 2023 Mar 6];21(4):203–14. Available from: https://www.researchgate.net/publication/311780605_Validation_Study_and_Quality_Assurance_of_Pharmaceutical_Water_Waterborne_Microorganisms_and_Endotoxins

General Chapters: <1231> WATER FOR PHARMACEUTICAL PURPOSES [Internet]. [cited 2023 Mar 6]. Available from: http://pharmacopeia.cn/v29240/usp29nf24s0_c1231.html

Aquatech | Industrial Uses of Water | Essential Guide [Internet]. [cited 2023 Mar 8]. Available from: https://www.aquatechtrade.com/news/industrial-water/industrial-water-essential-guide/

Quality of Water for Pharmaceutical Use - YouTube [Internet]. [cited 2023 Mar 8]. Available from: https://www.youtube.com/watch?v=JepGvnzVyvM

Quality assurance of pharmaceuticals A compendium of guidelines and related materials. 2007;

Purified Water Is Key In Pharmaceutical Quality Control Testing [Internet]. [cited 2023 Mar 8]. Available from: https://www.smacgigworld.com/blog/purified-water-is-key-in-pharmaceutical-quality-control-testing.php

Drug Quality Sampling and Testing Programs | FDA [Internet]. [cited 2023 Mar 8]. Available from: https://www.fda.gov/drugs/science-and-research-drugs/drug-quality-sampling-and-testing-programs

Boboc M, Curti F, Fleaca AM, Jianu ML, Rosu AM, Curutiu C, et al. Preparation and Antimicrobial Activity of Inorganic Nanoparticles: Promising Solutions to Fight Antibiotic Resistance. Nanostructures for Antimicrobial Therapy: Nanostructures in Therapeutic Medicine Series. 2017 May 31;325–40.

What is total viable count in water testing and why is it important? [Internet]. [cited 2023 Mar 6]. Available from: https://www.wcs-group.co.uk/wcs-blog/total-viable-count-in-water-testing

Associates of Cape Cod, Inc. - Endotoxin & Glucan Reference Info [Internet]. [cited 2023 Mar 6]. Available from: https://www.acciusa.com/products-and-services/contract-test-services/endotoxin-and-glucan-reference-info/

Endotoxin Detection Methods for Pharmaceuticals [Internet]. [cited 2023 Mar 6]. Available from: https://www.rapidmicrobiology.com/test-method/endotoxin-detection-methods-for-pharmaceuticals-and-medical-devices

Popek E. Practical Approach to Sampling. Sampling and Analysis of Environmental Chemical Pollutants. 2018 Jan 1;145–225.

Why Conductivity Is Important in Purified Water Quality Testing [Internet]. [cited 2023 Mar 6]. Available from: https://blog.jencoi.com/why-conductivity-is-important-in-purified-water-quality-testing

Pharmaceutical and Healthcare Sciences Society. Beckman Coulter. European Pharmacopoeia EP 2.2.44 and Total Organ. 2008 [cited 2023 Mar 6];44. Available from: https://www.news-medical.net/whitepaper/20200519/Measuring-Total-Organic-Carbon-in-Pharma-Water-Systems.aspx

Total Organic Carbon (TOC): Back to Basics | American Pharmaceutical Review - The Review of American Pharmaceutical Business & Technology [Internet]. [cited 2023 Mar 8]. Available from: https://www.americanpharmaceuticalreview.com/Featured-Articles/569558-Total-Organic-Carbon-TOC-Back-to-Basics/

Analytical Methods for the Comprehensive Characterization of Produced Water - ScienceDirect [Internet]. [cited 2023 Mar 8]. Available from: https://www.sciencedirect.com/science/article/abs/pii/B9780128157305000090

Johnston A, Holt DW. Substandard drugs: a potential crisis for public health. Br J Clin Pharmacol [Internet]. 2014 [cited 2023 Mar 8];78(2):218. Available from: /pmc/articles/PMC4137817/

Europe I. Qualification of Excipients for Use in Pharmaceuticals. 2008;

qas20-842-rev1-gmp-water-for-pharmaceutical-use.

Nataraj HM, Vishal GN, Ravi G. Validation of water purification system. Asian Journal of Pharmaceutical and Clinical Research. 2017 Apr 1;10(4):409–16.

Dufour A, Snozzi M, Koster W, Bartram J, Ronchi E, Fewtrell L, et al. Pathogenic Mycobacteria in Water: A Guide to Public Health Consequences, Monitoring and Management [Internet]. 2003. Available from: www.iwapublishing.com

Water purification - Wikipedia [Internet]. [cited 2023 Mar 8]. Available from: https://en.wikipedia.org/wiki/Water_purification

STATUS OF WATER TREATMENT PLANTS IN INDIA CENTRAL POLLUTION CONTROL BOARD (MINISTRY OF ENVIRONMENT AND FORESTS) Website : www.cpcb.nic.in e-mail : cpcb@nic.in. [cited 2023 Mar 8]; Available from: www.cpcb.nic.in

Kartono R, Basuki YT. Strategic of Applying Free Chemical Usage In Purified Water System For Pharmaceutical Industry Toward CPOB (Cara Pembuatan Obat yang Baik) Indonesia To Reducing Environmental Pollution. [cited 2023 Mar 8]; Available from: http://www.epj-conferences.org

Aquatech | Water Treatment Technologies | Essential Guide [Internet]. [cited 2023 Mar 8]. Available from: https://www.aquatechtrade.com/news/water-treatment/water-treatment-essential-guide/

Water Purification Methods | Atlas Scientific [Internet]. [cited 2023 Mar 8]. Available from: https://atlas-scientific.com/blog/water-purification-methods/

Drinking water distribution systems: Assessing and reducing risks. Drinking Water Distribution Systems: Assessing and Reducing Risks. 2007 Jan 22;1–391.

Fick J, Söderström H, Lindberg RH, Phan C, Tysklind M, Larsson DGJ. Contamination of surface, ground, and drinking water from pharmaceutical production. Environ Toxicol Chem [Internet]. 2009 Dec [cited 2023 Mar 8];28(12):2522–7. Available from: https://pubmed.ncbi.nlm.nih.gov/19449981/

Pharmaceutical Contamination: Types, Causes and Prevention - Lindström [Internet]. [cited 2023 Mar 8]. Available from: https://lindstromgroup.com/in/article/pharmaceutical-contamination-types-causes-and-prevention/

Gadipelly C, Pérez-González A, Yadav GD, Ortiz I, Ibáñez R, Rathod VK, et al. Pharmaceutical industry wastewater: Review of the technologies for water treatment and reuse. Ind Eng Chem Res [Internet]. 2014 Jul 23 [cited 2023 Mar 8];53(29):11571–92. Available from: https://www.researchgate.net/publication/270342353_Pharmaceutical_Industry_Wastewater_Review_of_the_Technologies_for_Water_Treatment_and_Reuse

Annex 2 WHO good manufacturing practices: water for pharmaceutical use 1.

Standard Methods for the Examination of Water and Wastewater. 1999;

Purified Water Storage and Distribution System : Pharmaguideline [Internet]. [cited 2023 Mar 8]. Available from: https://www.pharmaguideline.com/2013/08/purified-water-storage-and-distribution-system.html

Water Purification Systems in Pharmaceutical Industry [Internet]. [cited 2023 Mar 8]. Available from: https://tsaprocessequipments.com/many-forms-of-water-purification-systems-in-the-pharmaceutical-industry/

Chapter 2 - WATER QUALITY MONITORING, STANDARDS AND TREATMENT [Internet]. [cited 2023 Mar 8]. Available from: https://www.fao.org/3/x5624e/x5624e05.htm

Corrosion Prevention in Aboveground and Underground Tanks [Internet]. [cited 2023 Mar 6]. Available from: https://www.corrosionpedia.com/corrosion-prevention-in-aboveground-and-underground-tanks/2/6965

Prevent Contamination and Corrosion in Demineralized Water Storage Tanks Using Nitrogen Sparging and Blanketing [Internet]. [cited 2023 Mar 6]. Available from: https://www.powermag.com/prevent-contamination-and-corrosion-in-demineralized-water-storage-tanks-using-nitrogen-sparging-and-blanketing/

Water Safety in Distribution Systems.

Ermer J, John JH. Method Validation in Pharmaceutical Analysis: A Guide to Best Practice. Method Validation in Pharmaceutical Analysis: A Guide to Best Practice [Internet]. 2005 Aug 5 [cited 2023 Mar 8];1–403. Available from: https://onlinelibrary.wiley.com/doi/book/10.1002/3527604685

Food and Drug Administration (FDA) - Safety Guidelines [Internet]. [cited 2023 Mar 8]. Available from: https://www.drugwatch.com/fda/

USP Standards For Purified Water | Pharmate Systems [Internet]. [cited 2023 Mar 6]. Available from: https://pharmatesystems.com/usp-standards-for-purified-water/

Quality of water for pharmaceutical use - Scientific guideline | European Medicines Agency [Internet]. [cited 2023 Mar 6]. Available from: https://www.ema.europa.eu/en/quality-water-pharmaceutical-use-scientific-guideline

4 Committee for Medicinal Products for Human Use (CHMP) 5 Committee for Medicinal Products for Veterinary Use (CVMP) 6 7 Guideline on the quality of water for pharmaceutical use. 2018 [cited 2023 Mar 6]; Available from: www.ema.europa.eu/contact

Fda. Guidance for Industry ANDAs: Pharmaceutical Solid Polymorphism Chemistry, Manufacturing, and Controls Information. 2007 [cited 2023 Mar 8]; Available from: http://www.fda.gov/cder/guidance/index.htm

International Council for Harmonisation-Quality | FDA [Internet]. [cited 2023 Mar 8]. Available from: https://www.fda.gov/drugs/guidances-drugs/international-council-harmonisation-quality

ICH Topic Q 6 A Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances Step 5 NOTE FOR GUIDANCE SPECIFICATIONS: TEST PROCEDURES AND ACCEPTANCE CRITERIA FOR NEW DRUG SUBSTANCES AND NEW DRUG PRODUCTS: CHEMICAL SUBSTANCES. 2000 [cited 2023 Mar 8]; Available from: http://www.emea.eu.int

Singh R. Hybrid membrane systems – applications and case studies. Hybrid Membrane Systems for Water Purification. 2005 Jan 1;131–96.

Medicines Agency E. Committee for Medicinal Products for Human Use (CHMP) Committee for Medicinal Products for Veterinary Use (CVMP) Guideline on the quality of water for pharmaceutical use. 2020 [cited 2023 Mar 8]; Available from: www.ema.europa.eu/contact

FAQs: Water for Pharmaceutical and Analytical Purposes | USP [Internet]. [cited 2023 Mar 8]. Available from: https://www.usp.org/frequently-asked-questions/water-pharmaceutical-and-analytical-purposes

Purified Water Specification as per IP/BP/USP : Pharmaguideline [Internet]. [cited 2023 Mar 8]. Available from: https://www.pharmaguideline.com/2011/08/purified-water-specification-as-per-ip.html

Prüfungsarbeit zur Erlangung des Titels W, Wolfram Gering H. Basic Requirements For Aseptic Manufacturing Of Sterile Medicinal Products A Comparison Between Europe And USA.

REVISED ANNEX 1 (MANUFACTURE OF STERILE MEDICINAL PRODUCTS) TO GUIDE TO GOOD MANUFACTURING PRACTICE FOR MEDICINAL PRODUCTS. 2022;

Medicines Agency E. Committee for Medicinal Products for Human Use (CHMP) Committee for Medicinal Products for Veterinary Use (CVMP) Guideline on the quality of water for pharmaceutical use. 2020 [cited 2023 Mar 6]; Available from: www.ema.europa.eu/contact

ICH Official web site : ICH [Internet]. [cited 2023 Mar 6]. Available from: https://www.ich.org/page/quality-guidelines

Corporate Compliance | Pfizer [Internet]. [cited 2023 Mar 6]. Available from: https://www.pfizer.com/about/responsibility/compliance

Wang Y. Pfizer Pharmaceuticals: Green Chemistry Innovation and Business Strategy Pharmaceuticals and Personal Care Products (PPCPs). 2009 [cited 2023 Mar 8]; Available from: http://www.epa.gov/ppcp/

Environmental, Social & Governance Report.

AstraZeneca - Research-Based BioPharmaceutical Company [Internet]. [cited 2023 Mar 6]. Available from: https://www.astrazeneca.com/

The Expert Committee on Specifications for Pharmaceutical WHO Expert Committee on Specifications for Pharmaceutical Preparations Forty-sixth report. [cited 2023 Mar 8]; Available from: www.who.int/bookorders

Industrial UV Water Disinfection System Applications - Membracon [Internet]. [cited 2023 Mar 8]. Available from: https://www.membracon.co.uk/blog/industrial-uv-water-disinfection-system-applications/

Industrial UV For Water Disinfection & Treatment Systems | Water Sterilizer [Internet]. [cited 2023 Mar 8]. Available from: https://www.alfaauv.com/markets/industrial/

What we do [Internet]. [cited 2023 Mar 6]. Available from: https://www.novonordisk.com/about/what-we-do.html

Who we are [Internet]. [cited 2023 Mar 6]. Available from: https://www.novonordisk.com/about/who-we-are.html

Novo Nordisk | Pharmaceutical Industry Case Study | Blue Ocean Strategy Example [Internet]. [cited 2023 Mar 8]. Available from: https://www.blueoceanstrategy.com/blue-ocean-strategy-examples/novo-nordisk/

Stanford University Case Study: Novo Nordisk [Internet]. [cited 2023 Mar 8]. Available from: https://www.slideshare.net/sstrumello/stanford-university-case-study-novo-nordisk

Elix® 20/35/70/100 Water Purification System - Elix - Type 2 Pure Water [Internet]. [cited 2023 Mar 6]. Available from: https://www.merckmillipore.com/IN/en/product/Elix-20-35-70-100-Water-Purification-System,MM_NF-C8673

Merck and Safe Water Network Launch Initiative to Improve Water Access and Help Reduce the Impact of Water-Borne Disease in India - Merck.com [Internet]. [cited 2023 Mar 6]. Available from: https://www.merck.com/news/merck-and-safe-water-network-launch-initiative-to-improve-water-access-and-help-reduce-the-impact-of-water-borne-disease-in-india/

Grote F, Ditz R, Strube J. Downstream of downstream processing: development of recycling strategies for biopharmaceutical processes. Journal of Chemical Technology & Biotechnology [Internet]. 2012 Apr 1 [cited 2023 Mar 8];87(4):481–97. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/jctb.2727

Environmental, Social & Governance (ESG) Progress Report 2020/2021.

Bhagwat VR. Safety of Water Used in Food Production. Food Safety and Human Health [Internet]. 2019 Jan 1 [cited 2023 Mar 6];219. Available from: /pmc/articles/PMC7150035/

Palmer RN, Lundberg K V. INTEGRATED WATER RESOURCE PLANNING PREPARED BY.

Laboratory NRC (US) C on PP in the. Environmental Health and Safety Management System. 2011 [cited 2023 Mar 8]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK55873/