Nonsurgical Infraorbital Rejuvenation: A Study on the use of Cost-effective Autologous Biofiller

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MC. Prashant
Kapil Lahoti
Khushboo Chhabaria Peswani
Akshay Kumar Mavani
Aakanksha Sharma
Manish Jain


Background– The aging of the mandibular area is influenced in part by the infraorbital region, a very impressionable area. Traditional treatments included surgical removal of skin, muscles, and fat, in addition to other non-invasive procedures like as chemical peels and dermal fillers. Autologous plasma gelbiofiller is a gelatinous material created from the patient's platelet-poor plasma.

Aim and Objectives- The purpose of this study is to assess the efficacy of Biofiller in reducing wrinkle depth and improving infraorbital skin texture.

Methods– Twenty-five people, ages 40 to 65, were recruited at random to participate in a prospective observational study at the RKDF Dental College and Research Center in Bhopal. Biofiller and platelet deficient plasma gel are injected using a 30 gauge needle. Per eyelid, the volume using the linear thread method may be anything from 0.1 to 0.45 ml. Lemperle's defect scale, a visual simple scale (VAS), and a visual record recorded before and after four months of therapy were used to assess the cases.

Result– The research had 25 total participants. Average wrinkle severity was 2.29 before treatment and 1 after. This result was supported by statistical analysis. Only 4 patients reported only moderate improvement (VAS 2+), while 1 patient reported no change in texture or volume. Two people had side effects of bruising, and one person experienced side effects of swelling after 24 hours.

Conclusion– An alternate and more cost-effective method for infraorbital rejuvenation is the use of a platelet deficient plasma gel or biofiller.

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How to Cite
MC. Prashant, Kapil Lahoti, Khushboo Chhabaria Peswani, Akshay Kumar Mavani, Aakanksha Sharma, & Manish Jain. (2023). Nonsurgical Infraorbital Rejuvenation: A Study on the use of Cost-effective Autologous Biofiller. Journal of Coastal Life Medicine, 11(1), 2099–2106. Retrieved from


Narurkar V, Shamban A, Sissins P, Stonehouse A, Gallagher C. Facial treatment preferences in aesthetically aware women. Dermatol Surg. 2015;41(suppl 1):S153–S160.

Sadick NS, Bosniak SL, Cantisano-Zilkha M, Glavas IP, Roy D. Definition of the tear trough and the tear trough rating scale. J Cosmet Dermatol. 2007;6(4):218–222.

Sharad J. Dermal fillers for the treatment of tear trough deformity: a review of anatomy, treatment techniques, and their outcomes. J CutanAesthet Surg. 2012;5(4):229–238.

Lee JH, Hong G. Definitions of groove and hollowness of the infraorbital region and clinical treatment using soft-tissue filler. Arch Plast Surg. 2018;45(3):214–221.

Flowers RS. Tear trough implants for correction of tear trough deformity. Clin Plast Surg. 1993;20(2):403–415.

Swift A, Liew S, Weinkle S, Garcia JK, Silberberg MB. The facial aging process from the “inside out”. Aesthet Surg J. 2021;41(10):1107–1119.

Peng PH, Peng JH. Treating the tear trough: a new classification system, a 6-step evaluation procedure, hyaluronic acid injection algorithm, and treatment sequences. J Cosmet Dermatol. 2018;17(3):333–339.

Lipp M, Weiss E. Nonsurgical treatments for infraorbital rejuvenation: a review. Dermatol Surg. 2019;45(5):700–710.

Stutman RL, Codner MA. Tear trough deformity: review of anatomy and treatment options. Aesthet Surg J. 2012;32(4):426–440.

Diwan Z, Trikha S, Etemad-Shahidi S, Alli Z, Rennie C, Penny A. A prospective study on safety, complications and satisfaction analysis for tear trough rejuvenation using hyaluronic acid dermal fillers. PlastReconstr Surg Glob Open. 2020;8(4):e2753.

Rzany B, Cartier H, Kestermont P, et al.. Correction of tear troughs and periorbital lines with a range of customized hyaluronic acid fillers. J Drugs Dermatol. 2012;11(1 Suppl):s27–s34.

Morley AM, Malhotra R. Use of hyaluronic acid filler for tear-trough rejuvenation as an alternative to lower eyelid surgery. OphthalPlastReconstr Surg. 2011;27(2):69–73.

Fabi S, Zoumalan C, Fagien S, Yoelin S, Sartor M, Chawla S. A prospective, multicenter, single-blind, randomized, controlled study of VYC-15L, a hyaluronic acid filler, in adults for correction of infraorbital hollowing. Aesthet Surg J. 2021;41(11):NP1675–NP1685.

Raspaldo H, Gassia V, Niforos FR, Michaud T. Global, 3-dimensional approach to natural rejuvenation: part 1—recommendations for volume restoration and the periocular area. J Cosmet Dermatol. 2012;11(4):279–289.

Glaser DA, Lambros V, Kolodziejczyk J, Magyar A, Dorries K, Gallagher CJ. Relationship between midface volume deficit and the appearance of tear troughs and nasolabial folds. Dermatol Surg. 2018;44(12):1547–1554.

Weinkle SH, Werschler WP, Teller CF, et al.. Impact of comprehensive, minimally invasive, multimodal aesthetic treatment on satisfaction with facial appearance: the HARMONY study. Aesthet Surg J. 2018;38(5):540–556.

Few J, Cox SE, Paradkar-Mitragotri D, Murphy DK. A multicenter, single-blind randomized, controlled study of a volumizing hyaluronic acid filler for midface volume deficit: patient-reported outcomes at 2 years. Aesthet Surg J. 2015;35(5):589–599.

Anido J, Fernández JM, Genol I, Ribé N, Pérez Sevilla G. Recommendations for the treatment of tear trough deformity with cross-linked hyaluronic acid filler. J Cosmet Dermatol. 2021;20(1):6–17.

Palermo EC. Anatomy of the periorbital region. Surg Cosmet Dermatol. 2013;5(3):245–256.

Codner MA, Locke MB. Applied anatomy of the eyelids and orbit. In: Nahai F, ed. The Art of Aesthetic Surgery: Principles & Techniques, 2nd ed.St. Louis, MO: Quality Medical Publishing; 2011:807–830.

Woodward J. Review of periorbital and upper face: pertinent anatomy, aging, injection techniques, prevention, and management of complications of facial fillers. J Drugs Dermatol. 2016;15(12):1524–1531.

Woodward JA. Periocular fillers and related anatomy. Cutis 2016;98(5):330–335.

Griepentrog GJ, Lemke BN, Burkat CN, RoseJG, Jr., Lucarelli MJ. Anatomical position of hyaluronic acid gel following injection to the infraorbital hollows. OphthalPlastReconstr Surg. 2013;29(1):35–39.

Gierloff M, Stohring C, Buder T, Gassling V, Acil Y, Wiltfang J. Aging changes of the midfacial fat compartments: a computed tomographic study. PlastReconstr Surg. 2012;129(1):263–273.

Surek CC, Beut J, Stephens R, Jelks G, Lamb J. Pertinent anatomy and analysis for midface volumizing procedures. PlastReconstr Surg. 2015;135(5):818e–829e.