Study of Thyroid Dysfunction in Patients with Metabolic Syndrome

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Sakshi Bhaleghare
Nitin Jadhav
Nikhilesh Rayannavar


Background: Thyroid impairment is common in patients with metabolic syndrome. The study's goal was to learn more about the interplay between tests for thyroid function and other markers of metabolic syndrome. Subject matter and method: According to the NCEP- ATP III diagnostic criteria for metabolic syndrome, 61 individuals with the condition were included in the research and divided into three groups. Thyroid tests were performed and compared to criteria for metabolic syndrome. The results showed that out of a total of 61 patients diagnosed with MetS, 24 (39.3 percent) were men, while 37 (60.7 percent) were female, for a ratio of men to women of 1:1.5. The average age of participants was 53.69 14.78 years old.  A majority of the patients belonged to the age group of ≥ 61 years. Of the 61 patients with MetS, 31 (50.8%) subjects had 3 components of MetS, 17 (27.9%) had 4 components of MetS and 13 (21.3%) had 5 components of MetS. The prevalence of metabolic syndrome in euthyroid, subclinical hypothyroid, hypothyroid, subclinical hyperthyroid and hyperthyroid patients was 67.2%, 9.8%, 13.1%, 6.6% and 3.3% respectively. The prevalence of thyroid dysfunction was 32.8%. Among 13 patients who had 5 components of MetS, only 5 (38.5%) patients were euthyroid and 8 (61.5%) had thyroid dysfunction. Conclusion: Overt hypothyroidism was the most frequent thyroid dysfunction observed in the present study. This study concludes that thyroid dysfunction increases as the number of metabolic syndrome components increases. Therefore, every patient with metabolic syndrome should be screened for thyroid function tests.

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Sakshi Bhaleghare, Nitin Jadhav, & Nikhilesh Rayannavar. (2023). Study of Thyroid Dysfunction in Patients with Metabolic Syndrome . Journal of Coastal Life Medicine, 11(1), 2107–2115. Retrieved from


Expert Panel on Detection, Evaluation, andTreatment of High Blood Cholesterol in Adults.Executive summary of the third report of thenational cholesterol education program (NCEP)expert panel on detection, evaluation, andtreatment of high blood cholesterol in adults(Adult Treatment Panel III). JAMA 2001; 285:2486–2497

Alberti KG, Zimmet P, Shaw J, et al. The metabolic syndrome – a new worldwide definition. Lancet 2005; 366: 1059–1062

Cappola AR et al., Hypothyroidism and atherosclerosis J Clin Endocrinol Metab 2003; 88:2438-2444.

Deshmukh V, Farishta F, Bhole M. Thyroid Dysfunction in Patients with Metabolic Syndrome: A Cross-Sectional, Epidemiological, Pan-India Study. Int J Endocrinol. 2018 Dec 25;2018:2930251. doi: 10.1155/2018/2930251. PMID: 30675157; PMCID: PMC6323507.

He J, Lai Y, Yang J, Yao Y, Li Y,Teng W and Shan Z (2021). The Relationship Between Thyroid Function and Metabolic Syndrome and Its Components: A Cross-Sectional Study in a Chinese Population. Front. Endocrinol. 12:661160. doi: 10.3389/fendo.2021.661160

Prabin Gyawali, Jyoti Shrestha Takanche, Raj Kumar Shrestha. Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome. Diabetes Metab J 2015;39:66-73.

Saroj Khatiwada, Santosh Kumar Sah, Rajendra KC. Thyroid dysfunction in metabolic syndrome patients and its relationship with components of metabolic syndrome. Clinical Diabetes and Endocrinology (2016) 2:3. DOI 10.1186/s40842-016-0021-0.

Ritu Gupta, Akhil K Vijayan, Sushma Choudhary. Thyroid dysfunction in patients of metabolic syndrome: A study from a tertiary care center in India. Asian Journal of Medical Sciences. DOI: 10.3126/ajms.v12i10.38313.

Ghanshyam Palamaner Subash Shantha, Anita A Kumar,Vijay Jeyachandran. Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross–sectional study from South India. Thyroid Research 2009, 2:2 doi:10.1186/1756-6614-2-2.

Dr E. Prabhu, Dr M.S. Senthil Kumar. A Study of Thyroid Dysfunction in Patients with Metabolic Syndrome. JMSCR.