Phytochemical Evaluation, Nephroprotective and Hematological Modulating Effects of Ethanol leaf extract of Jatropha tanjorensis on Wistar Rats
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Abstract
Aim: This study is aimed at invstigating the effect of Jatrophatanjorensis leaves extract on modulating hematology, renal function of wistar rats and phytochemicals.
Method: A total of thirtyfive adult wistar rats were randomly divided into five groups, with 7 rats each respectively in each of the group. Normal control (group A) was administered distilled water, Group B, C, D & E was administered 250, 350, 450, and 550mg/kg b.w, respectively of the plant extract. The extraction and all biochemical analysis were carried out using standard laboratory techniques.
Results: The results showed that Jatrophatanjorensis extract caused significant changes at (P < 0.05) in the packed cell volume (PCV) of the administered groups compared to the normal control group due to the extract. However, the administered group showed no significant increase at (P < 0.05) in white blood cell count (WBC) of administered groups compared to the control group. The results of the renal was significantly reduced at (P < 0.05) sodium chloride potassium and no significant difference (P < 0.05) in urea concentration in comparison to the normal control groups of sodium, chloride, potassium,and urea respectively. Phytochemical screening revealed the presence of tannins, quinone, terpenonid, steroid, phenols, anthraquinones and flavonoids in Jatrophatanjorensis leaf extract.
Conclusion:Jatrophatanjorensis improve the blood volume and may be used in the management of anaemic conditions in patients , It has no toxic effects on the renal function and it also contains phytochemicals, which may be used as pharmacological probe.
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Aim: This study is aimed at invstigating the effect of Jatrophatanjorensis leaves extract on modulating hematology, renal function of wistar rats and phytochemicals.
Method: A total of thirtyfive adult wistar rats were randomly divided into five groups, with 7 rats each respectively in each of the group. Normal control (group A) was administered distilled water, Group B, C, D & E was administered 250, 350, 450, and 550mg/kg b.w, respectively of the plant extract. The extraction and all biochemical analysis were carried out using standard laboratory techniques.
Results: The results showed that Jatrophatanjorensis extract caused significant changes at (P < 0.05) in the packed cell volume (PCV) of the administered groups compared to the normal control group due to the extract. However, the administered group showed no significant increase at (P < 0.05) in white blood cell count (WBC) of administered groups compared to the control group. The results of the renal was significantly reduced at (P < 0.05) sodium chloride potassium and no significant difference (P < 0.05) in urea concentration in comparison to the normal control groups of sodium, chloride, potassium,and urea respectively. Phytochemical screening revealed the presence of tannins, quinone, terpenonid, steroid, phenols, anthraquinones and flavonoids in Jatrophatanjorensis leaf extract.
Conclusion:Jatrophatanjorensis improve the blood volume and may be used in the management of anaemic conditions in patients , It has no toxic effects on the renal function and it also contains phytochemicals, which may be used as pharmacological probe.