Pediatric Status Epilepticus Clinical Profile and Short-Term Results Prospective cohort study

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Chiranth Nadig


Introduction: In order to avoid permanent brain damage and death, “Status Epilepticus (SE)” is a medical emergency that needs to be treated right away. The motive of this research was to describe the clinical characteristics and immediate results of pediatric SE patients.

Methods: A prospective cohort study involving patients with SE from 1 month to 18 years old was carried out in a tertiary care facility. Data from the clinical, laboratory, and demographic sources were gathered and examined.

Results: The mean age of the 65 subjects who were enrolled was 7.6 ±4.2 years, and 35 (53.8%) of them were men. The two most prevalent causes of SE were acute symptoms (52.3%) and fever (30.8%). Generalized convulsive seizures were the most common seizure type (80.0%), and their median duration was 60 minutes. 56 (86.2%) patients received intravenous benzodiazepines as the first line of treatment, while 35 (53.8%) patients received antiepileptic medications as the second line of treatment. Within 60 minutes of the start of treatment, 35 patients (53.8%) had completely recovered from SE. Respiratory depression (6.2%) and SE refractory to therapy (7.7%) were the two main consequences, and the mortality rate was 7.7%.

Conclusion: This prospective cohort study sheds light on pediatric SE's short-term prognoses and clinical features in tertiary care hospitals. The findings show that most people recover from SE within 60 minutes of beginning treatment. Second-line phenytoin may worsen SE severity and decrease SE resolution

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How to Cite
Chiranth Nadig. (2023). Pediatric Status Epilepticus Clinical Profile and Short-Term Results Prospective cohort study. Journal of Coastal Life Medicine, 11(1), 2359–2365. Retrieved from


DeLorenzo RJ, Pellock JM, Towne AR, Boggs JG. Epidemiology of status epilepticus. J Clin Neurophysiol. 1995;12(4):316-325.

Abend NS, Loddenkemper T. Management of pediatric status epilepticus. Curr Treat Options Neurol. 2014;16(7):301. doi:10.1007/s11940-014-0301-x.

Owens J. Medical management of refractory status epilepticus. Semin Pediatr Neurol. 2010;17(3):176-181. doi:10.1016/j.spen.2010.06.006.

Shinnar S, Pellock JM. Update on the epidemiology and prognosis of pediatric epilepsy. J Child Neurol. 2002;17 Suppl 1:S4-S17.

Brophy GM, Bell R, Claassen J, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care. 2012;17(1):3-23.

Abend NS, Gutierrez-Colina AM, Dlugos DJ. Medical treatment of pediatric status epilepticus. Semin Pediatr Neurol. 2010;17(3):169-175. doi:10.1016/j.spen.2010.06.005.

Shorvon S. The management of status epilepticus. J Neurol Neurosurg Psychiatry. 2001;70 Suppl 2:ii22-ii27.

Chin RF, Neville BG, Peckham C, et al. Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study. Lancet Neurol. 2008;7(8):696-703.

Vossler DG, Bainbridge JL, Boggs JG, et al. Treatment of Refractory Convulsive Status Epilepticus: A Comprehensive Review by the American Epilepsy Society Treatments Committee. Epilepsy Curr. 2020;20(5):245-264. doi:10.1177/1535759720928269.

Glauser T, Shinnar S, Gloss D, et al. Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr. 2016;16(1):48-61.

Abend NS, Gutierrez-Colina AM, Topjian AA, et al. Non-convulsive seizures are common in critically ill children. Neurology. 2011;76(12):1071-1077.

Sánchez Fernández I, Abend NS, Arndt DH, et al. Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter study. J Pediatr. 2014;164(2):339-46.e462. doi:10.1016/j.jpeds.2013.09.032

Topjian AA, Gutierrez-Colina AM, Sanchez SM, et al. Electrographic status epilepticus is associated with mortality and worse short-term outcome in critically ill children. Crit Care Med. 2013;41(1):215-223. doi:10.1097/CCM.0b013e3182668035

Chetan C, Sharma S, Mathur SB, Jain P, Aneja S. Clinical Profile and Short-term Outcome of Pediatric Status Epilepticus at a Tertiary-care Center in Northern India. Indian Pediatr. 2020;57(3):213-217.

JanarthananM, JayaramanD, ScottJ, LathaMS, MargabandhuS, SundaramoorthyC, et al.Primary antiphospholipid syndrome in children: experience from two tertiary centres in South India. Int J Contemp Pediatr 2019;6:243-7.