Evaluation of Renal Growth and Function in Preterm Infants at Corrected Age of 12-18 Months a cross-sectional observational study
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Abstract
Introduction: The preterm birth is a significant risk factor for the development and function of a baby's kidneys. However, very little research has been done on the growth and function of the kidneys in preterm infants between the ages of 12 and 18 months. Evaluation of renal development and function in preterm infants at 12-18 months of corrected age is the goal of this study.
Methods: The methodology for this observational cross-sectional study was carried out at Indian tertiary care facilities. Included were neonatal intensive care unit-admitted preterm infants under 37 weeks. The length and volume of the kidneys were assessed using ultrasound technology to determine renal growth. Evaluation of renal function was accomplished by measuring creatinine in the serum, blood urea nitrogen, and eGFR.
Results: The findings demonstrated that preterm neonates had significantly lower kidney volumes and mean values compared to term newborns (p-value <0.001). Protein levels in preterm babies' urine ranged from 37.4 to 27.4 mg/dL, while levels of creatinine in term babies' urine ranged from 0.48 to 0.09 mg/dL. The p-values for urinary protein excretion and serum creatinine levels were respectively 0.72 and 0.53. A person was considered to have hypertension if either their systolic or diastolic blood pressure was higher than the 95th percentile for their age, gender, and height. There was a significant difference in the prevalence of hypertension between preterm infants (8.2%) and term newborns (2.1%) (p-< 0.05).
Conclusion: This study helps evaluate renal growth and function in preterm infants between the ages of 12 and 18 months when they were corrected for age. The proper growth and function of the kidneys in preterm babies at this age can help guide clinical care and follow-up.
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References
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