Incidence of Cleft Lip and Palate Between Siblings in South Indian Population
Main Article Content
Aim: This study set out to look at the incidence of cleft lip and palate between siblings in the South Indian population
Materials and methods: Saveetha Dental College and Hospital's Oral & Maxillofacial Surgery Unit treated fifty cleft patients who also have siblings. The incidence of clefting in the family was researched using the history of consanguineous marriage.
Results: Eighty percent of patients had a cleft history, most commonly in younger siblings, while also there is an Increased incidence of the cleft with parents who have consanguineous marriage.
Conclusion: There is a strong correlation between CP and being related by blood. This study's findings on the frequency of consanguinity and the resulting heaviness of congenital disabilities highlight the critical importance of establishing a national registry for congenital anomalies such as craniofacial defects.
Centers for Disease Control and Prevention (CDC). Economic costs of birth defects and cerebral palsy – United States, 1992. MMWR Morb Mortal Wkly Rep 1995;44:6949.
Shaw W. Global strategies to reduce the health care burden of craniofacial anomalies: Report of WHO Meetings on International Collaborative Research on Craniofacial Anomalies. Cleft Palate Craniofac J 2004;41:23843.
Reddy SG, Reddy RR, Bronkhorst EM, Prasad R, Ettema AM, Sailer HF, et al. Incidence of cleft Lip and palate in the state of Andhra Pradesh, South India. Indian J PlastSurg2010;43:1849.
Mossey P, Little J. Addressing the challenges of cleft lip and palate research in India. Indian J PlastSurg 2009;42 Suppl1:S918.
Aljohar A, Ravichandran K, Subhani S. Pattern of cleft lip and palate in hospitalbased population in Saudi Arabia: Retrospective study. Cleft Palate Craniofac J 2008;45:5926.
Bittles AH, Black ML. Evolution in health and medicine Sackler colloquium: Consanguinity, human evolution, and complex diseases. Proc Natl Acad Sci U S A 2010;107 Suppl 1:177986.
Bittles AH, Black ML. Global Prevalence of Consanguinity; 2015. Available from: http://www.consang.net/index.php/Global_ prevalence. [Last accessed on 2015 Mar 20].
Mehndiratta MM, Paul B, Mehndiratta P. Arranged marriage, consanguinity, and epilepsy. Neurol Asia 2007;12:157.
Bittles AH, Black ML. The impact of consanguinity on neonatal and infant health. Early Hum Dev 2010;86:73741.
Bittles AH, Shami SA Appaji Rao N. Consanguineous marriage in Southern Asia: Incidence, causes, and effects. In: Bittles AH, Roberts DF, editors. Minority Populations: Genetics, Demography, and Health. London: Macmillan; 1992. p. 1028
Hagberg C, Larson O, Milerad J. Incidence of cleft lip and palate and risks of additional malformations. Cleft Palate Craniofac J 1998;35:40–5.
Census India. Literacy and Level of Education in India; 2011. Available from: http://www.censusindia.gov.in/2011census/ population_enumeration.html. [Last accessed on 2015 Mar 22].
Jose BA, Subramani SA, Mokhasi V, Jayan M. Consanguinity and clefts in the craniofacial region: A retrospective casecontrol study. J Cleft Lip Palate Craniofacial Anomalies 2015;2:1137.
Ravichandran K, Shoukri M, Aljohar A, Shazia NS, AlTwaijri Y, Al Jarba I. Consanguinity and occurrence of cleft lip/palate: A hospitalbased registry study in Riyadh. Am J Med Genet A 2012;158A: 5416.
Shahin H, Sharaha U, Lee MK, Watts A, King MC, van Aalst J, et al. Targeted Capture and Sequencing Identify Causative Alleles in Simplex and Multiplex Consanguineous Palestinian Families with Orofacial Clefts. 63rd Annual Meeting of the American Society of Human Genetics, Boston, USA; 2226 October, 2013.
World Health Organisation. Global registry and database on craniofacial anomalies. Human genetics programme: International Collaborative Research on Craniofacial Anomalies. Geneva, Switzerland: WHO Publications; 2003.
World Health Organisation. Addressing the global challenges of craniofacial anomalies. Human genetics programme: Report of a WHO Meeting on International Collaborative Research on Craniofacial Anomalies. Geneva, Switzerland: WHO Publications; 2006.
Akshay Mohan, Harish Babu, Nivethigaa B. Assessment Of Association Between Age, Gender, Consanguinity And Cleft Deformity - A Retrospective Analysis. Int J Dentistry Oral Sci. 2020;S1:02:0010:48-51. doi: dx.doi.org/10.19070/2377-8075-SI02-010010