A Potential Use of Dopamine Agonist and Monoamine Oxidase B Inhibitor in Parkinson’s Disease as Apply by Transdermal Patch.
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Abstract
Parkinson's disease (PD) is an advancing neurological disorder. The characteristic physical symptoms, which also include dopaminergic neuron loss and Lewy pathology, include rigidity, postural instability, bradykinesia, and resting tremors. Clinical symptoms in the elderly worsen over time due to decreased neurotransmitter levels, protein homeostasis disruption, mitochondrial malfunction, and oxidative stress. Parkinson's disease (PD) pathogenesis is likewise reliant on protein misfolding. and malfunction of the ubiquitin-proteasome system. The main purpose of continuous drug administration in PD is to maintain continuous dopaminergic activation, provide higher drug concentrations, prolong benefits, and reduce side effects. For example, transdermal delivery of monoamine oxidase-B or dopamine agonists inhibitors the drug delivery method itself may have an impact on a drug's bioavailability, which may therefore have an impact on a drug's effectiveness and tolerability, as well as on patient compliance. Additionally, examine the pharmacological and pharmacokinetic characteristics of dopamine agonists and MAO-B inhibitors for the treatment of Parkinson's disease in both its early and advanced stages
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References
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