Intrathecal Buprenorphine for Extended Postoperative Analgesia in Patients Undergoing Cesarean Section

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Priyanka Deshmukh
Sohal Parate
Pratibha Deshmukh
Shweta Takalkar


Background: For cesarean section analgesia, opioids are still the gold standard, but they do have a few potentially dangerous side effects that need to be taken into consideration. As a secondary objective, we looked at how long analgesia took to kick in and how severe the side effects were in both the mother and fetus in each of the two groups after surgery. Materials and methods: Subarachnoid block for elective cesarean birth enlisted the participation of 72 pregnant women in this randomized, double-blind trial. Participants in Group B got 45ug of buprenorphine dissolved in 45ug of 10% hyperbaric bupivacaine in 1.5ml saline, whereas those in Group C received 1.5ml saline mixed with 0.5 percent hyperbaric bupivacaine in 2ml (10mg). Motor block, sensory block, analgesia duration, the requirement for rescue analgesia, and any neonatal adverse effects were all detected. Students' t-test and the Chi-square test were used to determine the significance of the difference between the quantitative and subjective components. P-upsides of less than 0.05 were considered enormous. Results: The buprenorphine group had considerably longer analgesic duration (790.33±271.49 minutes) than the control group (296.55±75.13 minutes). The parturients in the research group needed much fewer rescue analgesic doses, and their pain scores were reduced as a result. Both groups saw very minor adverse effects. Conclusion: The current study shows that when low-dose buprenorphine (45g) is combined with bupivacaine, it can offer sustained analgesia during cesarean section without causing severe maternal or newborn adverse effects.

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Priyanka Deshmukh, Sohal Parate, Pratibha Deshmukh, & Shweta Takalkar. (2023). Intrathecal Buprenorphine for Extended Postoperative Analgesia in Patients Undergoing Cesarean Section. Journal of Coastal Life Medicine, 11(1), 2602–2607. Retrieved from


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