Differentially Expressed Genes in Patients with Peri-Implantitis

Abstract

Peri-implantitis is a biological complication that comprises a range of destructive inflammatory processes causing progressive loss of peri-implant bone and connective tissues, leading to morbidity and eventual implant failure. There is no gold standard treatment currently for this particular problem faced in the branch of dental implantology. Due to the absence of predictable and effective therapeutic interventions for the treatment of peri-implantitis, scientific evidence concerning the host response profile around dental implants could be of significant importance. In the future a wider preventive and/or therapeutic window for this aspect in peri-implant lesions exists, indicating efficient use of biomarkers that provide quantifiable measures of response to peri-implant therapy. The aim of this study was to compare messenger RNA (mRNA) expression profiles between peri-implantitis and healthy controls.  Differentially expressed genes (DEGs) in 6 peri-implantitis patients and 6 healthy individuals were analysed using mRNAs gene expression microarrays. 20792 common DEGs between healthy individuals and peri-implantitis patients groups were identified. Results indicated that peri-implantitis exhibit significantly different mRNAs expression profiles. Therefore, these findings highlight potential molecular targets for peri-implantitis therapy development.