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MicroRNAs, also known as miRNAs, are tiny, non-coding RNAs that regulate gene expression by base pairing with target miRNAs in the 3' untranslated region. MiRNAs are degraded or translation is suppressed as a result. MiRNAs have been linked to a wide range of biological functions, including cell proliferation, cell death, stress tolerance, and metabolic regulation. Extreme pH, long-term room temperature storage, numerous freeze thaw cycles, and RNAase activity do not seem to affect the stability of miRNA in tissues and biological fluids. Relationships between neutrophil gelatinase associated lipocalin (ngal) or kidney injury molecule-1 (kim-1) are examined, as well as the role that mirna-196 plays in CKD and CKD of unclear aetiology.
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