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In this work, the least and optimum effective doses of Cd and aqueous bark extract of TA were determined in the liver and heart tissues of male Wister rats via dosage and duration dependent investigations. Subcutaneous administration of 0.44 mg/kg b.w. of Cd every other day for 15 days was shown to be the minimal efficacious dosage for eliciting tissue damage. When administered orally once daily for 15 days, the highest protective effect of TA (20 mg/kg b.w.) was shown at this dosage. The effects of cadmium on biomarkers of organ damage, oxidative stress, and antioxidant enzyme activities were investigated.
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