Assessment of Stress and Related Biochemical Alterations in Type 2 Diabetes Mellitus and Obesity Patients
Main Article Content
The metabolic illness known as type 2 diabetes mellitus (T2DM) is still linked to physiological impairment and affects a sizable percentage of the world's population. There are a number of risk factors for developing type 2 diabetes, but obesity and altered basal metabolic rate are among the most prominent. About 80% of those with T2DM are also found to be obese; those with obesity have a higher risk of acquiring depression, and the disease is thought to double that risk. The vast majority of studies show that T2DM affects neuronal physiology via changing cortisol and adiponectin levels in the blood. This research looked at the correlation between metabolic disorders including type 2 diabetes and the stress and depression risk factors cortisol and adiponectin.
Pasquali R, Vicennati V, Cacciari M, Pagotto U. The hypothalamic-pituitary-adrenal axis activity in obesity and the metabolic syndrome. Ann N Y Acad Sci. 2016;1083:111-128.
Kim Y, Kim J, Kim KJ, et al. Association of depression with newly diagnosed type 2 diabetes among adults aged 50 or older: The Korean National Health and Nutrition Examination Survey 2017-2016. Psychiatry Investig. 2020;17(7):689-697.
Wallerius S, Rosmond R, Ljung T, Holm G, Björntorp P. Rise in morning saliva cortisol is associated with abdominal obesity in men: a preliminary report. J Endocrinol Invest. 2020;26(7):616-619.
Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell. 2021;116(2):337-350.
Goldstein DS. Adrenal responses to stress. Cell Mol Neurobiol. 2019;30(8):1433-1440.
Björntorp P. Do stress reactions cause abdominal obesity and comorbidities? Obes Rev. 2019;2(2):73-86.
Dallman MF, Pecoraro NC, la Fleur SE. Chronic stress and comfort foods: self-medication and abdominal obesity. Brain Behav Immun. 2017,19(4):275-280.
Bouayed J, Rammal H, Soulimani R. Oxidative stress and anxiety: relationship and cellular pathways. Oxid Med Cell Longev. 2019 (2):63-67.
Li C, Li X, Han H, et al. Chronic psychological stress induces liver injury via cortisol/GR pathway in diet-induced obesity mice. Psychoneuroendocrinology. 2018;96:39-47.
Qin F, Ye F, Luo R, et al. Chronic restraint stress-induced obesity-related outcomes in male C57BL/6J mice: a potential animal model of stress-induced obesity. J Neuroendocrinol. 2021;33(6):e12959.