Effect and Potential Mechanism of First-Line Oral Antitubercular Therapy Safety and Effectiveness with Adjuvant Drugs

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V. M. Thorat
D. V. Sarvaiya
Akash Devi


The purpose of this study is to examine the impact of adjuvant drugs on the safety and efficacy of first-line oral antitubercular therapy. This study was conducted at the pulmonary medicine outpatient department in Delhi, India, and was prospective and non-interventional. Adverse events occurred in 9 patients (18.75%) who did not take metformin and in 7 patients (14.58%) who did take it. (Chi-square test, P=.84) There was no discernible difference between the two groups. All of the reported side effects and problems involved the digestive system and were rather minor in nature. Given that our results suggest metformin might be used as an adjuvant antitubercular drug, particularly in those who have had both diabetes and TB, they are important for many stakeholders and policymakers.

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Thorat, V. M. . . . . . . . . ., Sarvaiya, D. V. . ., & Devi, A. (2023). Effect and Potential Mechanism of First-Line Oral Antitubercular Therapy Safety and Effectiveness with Adjuvant Drugs. Journal of Coastal Life Medicine, 11(1), 2818–2825. Retrieved from https://www.jclmm.com/index.php/journal/article/view/762


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