Subclinical Hypothyroidism: Biochemical and Molecular Cardiovascular Disease Risks

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Published: Jan 11, 2023
Keywords:
Cardiovascular disease Risks Subclinical Hypothyroidism

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Mandakini S. Kshirsagar
Assistant Professor, Department of Biochemistry Krishna Institute of Medical Sciences,Krishna Vishwa Vidyapeeth “Deemed To Be University”,Karad –415110,Maharashtra
R. Ajit V. Sontakke
Professor & Head, Department of Biochemistry Krishna Institute of Medical Sciences,Krishna Vishwa Vidyapeeth “Deemed To Be University”,Karad –415110,Maharashtra

Abstract

This research aims to find biochemical and molecular indicators of subclinical hypothyroidism that may be used to diagnose cardiovascular disease at an early stage. To determine which biochemical and molecular indicators are most useful for the early diagnosis of cardiovascular disease in people with subclinical hypothyroidism, a case-control research design was used in the current investigation. Results suggest that the mean CBMN frequency was higher in men than in women, and that the mean MN frequency was higher in those with lower HDL-C.

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How to Cite
Kshirsagar, M. S. ., & Sontakke, R. A. V. . (2023). Subclinical Hypothyroidism: Biochemical and Molecular Cardiovascular Disease Risks. Journal of Coastal Life Medicine, 11(1), 2850–2856. Retrieved from https://www.jclmm.com/index.php/journal/article/view/766
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Vol. 11: Number 1, 2023
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Articles

References

Cooper DS, Biondi B. Subclinical thyroid disease. Lancet. 2012;379:1142–1154.

Leese GP, Flynn RV, Jung RT, Macdonald TM, Murphy MJ, Morris AD. Increasing prevalence and incidence of thyroid disease in Tayside, Scotland: the Thyroid Epidemiology Audit and Research Study (TEARS) Clin Endocrinol (Oxf) 2008;68:311–316.

Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004;291:228–238.

Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008;29:76–131.

Kim YA, Park YJ. Prevalence and risk factors of subclinical thyroid disease. Endocrinol Metab (Seoul) 2014;29:20–29.

Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160:526–534.

Kim TH, Choi HS, Bae JC, Moon JH, Kim HK, Choi SH, et al. Subclinical hypothyroidism in addition to common risk scores for prediction of cardiovascular disease: a 10-year community-based cohort study. Eur J Endocrinol. 2014;171:649–657.

Knudsen N, Laurberg P, Rasmussen LB, Bulow I, Perrild H, Ovesen L, et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab. 2005;90:4019–4024.

Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU. The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab. 2007 Sep;92(9): 1715-23.

Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frölich M, Westendorp RG. Thyroid status, disability and cognitive function, and survival in old age. JAMA. 2004 Dec 1;292(21):2591-9.

Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010 Sep 22;304(12):1365-74.

Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008 Feb;29(1):76-131.