Formulation and Evaluation of Polyherbal Cream-Gel for Treatment of Rosacea

Abstract

Rosacea is a widespread, recurrent inflammatory skin disorder that impacts a large number of people globally. Rosacea is a prevalent, persistent, inflammatory skin condition whose cause is unknown. Cream-gel is the combination of cream and gel. Cream-gel products are pleasantly light and aid in the delivery of hydration, emolliency, and active ingredients.  As their name implies, they are a cream in a moisturising gel form, therefore there is no need for any conventional emulsifiers. The primary goal of the research is to create a polyherbal cream-gel utilising several herbs, and the effectiveness of the created cream-gel is assessed. The herbs used in the preparation of cream-gel are dried green tea leaves, curcumin, calendula oil. Phenolic acid, flavonoids, terpenoids, glycosides, and saponins are all present in the green tea leaf extract, curcumin and calendula oil which has antibacterial, antifungal, anti-inflammatory properties. The cream-gel was prepared by using fusion method. The main excipient used in preparation of cream-gel was Sepiplus 400 which is a combination of polyacrylate-13, polyisobutene, polysorbate-20. The Sepiplus 400 is used as film forming polymer, polymer, and non-ionic surfactant. The formulation of cream-gel was further evaluated for the various parameters like pH, viscosity, phase separation, spreadability, extrudability, compatibility etc. The results show that all formulations gave satisfied result. In order to treat effectively Rosacea, the present study of green tea leaves, curcumin, calendula oil boost drug penetration from the affected area, which may result in the treatment exhibiting antiinflammation, antifungal and antibacterial activities. The created herbal formulation was more successful at treating Rosacea symptoms than synthetic formulations because it was more stable, safe, and effective.