Clinical Evaluation of Chewable Probiotic Tablets as an Adjunct to Non-Surgical Periodontal Therapy in the Treatment of Periodontal Disease- A Pilot Project

Main Article Content

Shreya Shetty
Dara Kamal Mohammed Khan
Mawadah Mohammed Najeeb Khayat
Sarah Ali Hakami
Layan Samer Alsaadawi
Dania Basil Alsibaie


Introduction: Probiotics have been recently investigated as a promising adjunctive treatment along with scaling and roots planning for treating periodontal disease owing to their antimicrobial and anti-inflammatory characteristics. The present study set out to determine how probiotics affected several clinical markers of periodontal health. Methods: 62 Subjects diagnosed with Periodontitis were subjectively allocated to examination and controlling clusters based on such exclusion and inclusion criteria. The test group participants were administered probiotic chewable tablets (2 billion CFU) for 7 days following scaling and root planing (non-surgically  periodontal therapy) at baseline whereas the control group participants were only observed following scaling and root planning alone.Clinical periodontal parameters viz, oral hygiene index, bleeding index, periodontal pocket depth and clinical attachment loss were assessed at baseline, 30 days( 1 month)and 90 days( 3 months) follow-up. Results: Considering an intra-group P-value of less than 0.001, medical metrics significantly improved in both the experimental and control groups. Even though the test group's average variations were greater, intergroup interactions and analyses among the two groups showed no statistically significant variations (P > 0.05). Compared to the control group, the experimental( test) group had more obvious modifications to the disease condition. Conclusion: Probiotics may be beneficial as an adjunct to non-surgical periodontal rehabilitation in treating patients with periodontal disease.

Article Details

How to Cite
Shreya Shetty, Dara Kamal Mohammed Khan, Mawadah Mohammed Najeeb Khayat, Sarah Ali Hakami, Layan Samer Alsaadawi, & Dania Basil Alsibaie. (2023). Clinical Evaluation of Chewable Probiotic Tablets as an Adjunct to Non-Surgical Periodontal Therapy in the Treatment of Periodontal Disease- A Pilot Project. Journal of Coastal Life Medicine, 11(1), 3092–3104. Retrieved from


Retamal-Valdes, B., Teughels, W., Oliveira, L. M., da Silva, R. N., Fritoli, A., Gomes, P., & Feres, M. Clinical, microbiological, and immunological effects of systemic probiotics in periodontal treatment: study protocol for a randomized controlled trial. Trials, 22, 2021, 1-9.

Seligman, L., Huggins, C., & Gonzalez, M. J. Microbial ecology and probiotics in oral health. Journal of the American College of Nutrition, 37(6), 2018, 495-500.

Twetman, S. Probiotics and oral health effects in children. International Journal of Paediatric Dentistry, 30(2), 2020, 132-138.

Williams, Nancy Toedter. "Probiotics." American Journal of Health-System Pharmacy 67.6 (2010): 449-458.‏

Chatterjee, A., Bhattacharya, H., Kandwal, A. Probiotics in periodontal health and disease. Journal of Indian society of periodontology, 2011 Jan; 15(1):23.

Ishikawa, K. H., Mayer, M. P. A., Miyamoto, M., & Azevedo, J. L. Probiotics and oral health: A systematic review. Brazilian Oral Research, 29(1), 2015, 1-8.

Retamal-Valdes, B., Beltran-Aguilar, E. D., Herrera, D., Baelum, V., Lopez, R., & Aguilar, J. Clinical evaluation of chewable probiotic tablets as an adjunct to non-surgical periodontal therapy in the treatment of periodontal disease: A pilot study. Journal of Clinical Periodontology, 48(3), 2021, 383-390.

Kumar, P., Gupta, N., & Pal, M. Comparative evaluation of the efficacy of non-surgical periodontal therapy alone and in combination with low-level laser therapy in chronic periodontitis: A randomized controlled clinical trial. Journal of Indian Society of Periodontology, 25(1), 2021, 27-34.

Berezow, A. B., & Darveau, R. P. (2011). Microbial shift and periodontitis. Periodontology 2000, 55, 36– 47.

Tekce, M., Ince, G., Gursoy, H., Dirikan Ipci, S., Cakar, G., Kadir, T., & Yılmaz, S. Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: a 1‐year follow‐up study. Journal of clinical periodontology, 42(4), 2015, 363-372.

Martin‐Cabezas, R., Davideau, J. L., Tenenbaum, H., & Huck, O. Clinical efficacy of probiotics as an adjunctive therapy to non‐surgical periodontal treatment of chronic periodontitis: a systematic review and meta‐analysis. Journal of clinical periodontology, 43(6), 2016, 520-530.

Hojo, K., Nagaoka, S., Ohshima, T., Maeda, N., & Amano, A. Clinical evaluation of chewable probiotic tablets as an adjunct to non-surgical periodontal therapy in the treatment of periodontal disease- A pilot project. Journal of oral science, 49(4), 2007, 295-301.

Jothika M, Vanajassun PP, Someshwar B. Effectiveness of probiotic, chlorhexidine and fluoride mouthwash against Streptococcus mutans - Randomized, single-blind, in vivo study. J Int Soc Prevent Communit Dent; 2015, 5:44-8.

Shetty S, Srigiri SK and Sheikh KH A Comparative Clinical, Microbiological and Biochemical Evaluation of Guided Periodontal Pocket Recolonisation (GPR) using Synbiotics as an Adjunct to Scaling and Root Planing in Patients with Chronic Periodontitis: A Pilot Project. International Journal of Medical Research & Health Sciences, 2020, 9(5): 20-32

Feres, M., Figueiredo, L. C., Barreto, I. M., Coelho, M. H., Araujo, M. W., & Cortelli, S. C. In vitro antimicrobial activity of plant extracts and propolis in saliva samples of healthy and periodontally-involved subjects. Journal of the International Academy of Periodontology, 14(2), 2012, 28-34.

Saleh, M. H., Rincon, J., Tan, B., & Firth, J. D. The clinical effectiveness of probiotic chewing gum in the control of plaque and gingivitis: A systematic review. Journal of Clinical Periodontology, 43(7), 2016, 662-670.

Silva, L. B., Farias, A. C., Fraga, A. F., Prokopowitsch, I., & Rodrigues, L. K. The use of probiotics as an adjunctive therapy in the treatment of chronic periodontitis: A systematic review. Archives of Oral Biology, 56(9), 2011, 964-979.