Using of Amniotic Membrane Derivatives for the Treatment of Chronic Wounds
Main Article Content
Abstract
Background - Amniotic membrane (AM) can reset chronic wound healing, including re-epithelialization. Cell models have examined many AM effects on wound healing.
Materials and methods - This 18-month prospective observational study was conducted in the Surgery wards of Krishna Institute of Medical Sciences and Research Hospital, Karad. The study examined 100 patients.
Results - In this study, amniotic membrane dressings dramatically increased epithelialization and infection control on the 7th, 14th, and 21st days of follow-up. Amniotic membrane dressings considerably reduced exudation. Visual analogue scale pain scores were considerably lower in amniotic membrane dressing group. Thus, amniotic membrane is a low-bacterial biological skin replacement for diverse wounds. It also reduces fluid loss, infection, discomfort, wound healing, and handling.
Conclusion - This study concludes that amniotic membrane is one of the effective biological skin substitutes used in lesions of different etiologies, with minimal bacterial counts. In addition, it reduces the risk of infection, reduces pain, accelerates wound healing, and has excellent management properties.
Article Details
References
Dhall, S., Sathyamoorthy, M., Kuang, J. Q., Hoffman, T., Moorman, M., Lerch, A., Jacob, V., Sinclair, S. M., & Danilkovitch, A. (2018). Properties of viable lyopreserved amnion are equivalent to viable cryopreserved amnion with the convenience of ambient storage. PLOS ONE, 13(10), e0204060.
Fénelon, M., Catros, S., Meyer, C., Fricain, J. C., Obert, L., Auber, F., Louvrier, A., & Gindraux, F. (2021). Applications of Human Amniotic Membrane for Tissue Engineering. Membranes, 11(6), 387.
Fernandes, M., Sridhar, M. S., Sangwan, V. S., & Rao, G. N. (2005). Amniotic Membrane Transplantation for Ocular Surface Reconstruction. Cornea, 24(6), 643–653.
Fukuda, K., Chikama, T. I., Nakamura, M., & Nishida, T. (1999). Differential Distribution of Subchains of the Basement Membrane Components Type IV Collagen and Laminin Among the Amniotic Membrane, Cornea, and Conjunctiva. Cornea, 18(1), 73–79.
Gupta, A., Kedige, S. D., & Jain, K. (2015). Amnion and Chorion Membranes: Potential Stem Cell Reservoir with Wide Applications in Periodontics. International Journal of Biomaterials, 2015, 1–9.
Hanumanthappa, M. B., Gopinathan, S., Suvarna, R., Guruprasad, R. D., Shetty, G., Shetty, K., ... & Nazar, Z. (2012). Amniotic membrane dressing versus normal saline dressing in non-healing lower limb ulcers: A prospective comparative study at a Teaching Hospital. Journal of Clinical and Diagnostic Research, 6(3), 423-427.
Haugh, A. M., Witt, J. G., Hauch, A., Darden, M., Parker, G., Ellsworth, W. A., & Buell, J. F. (2017). Amnion Membrane in Diabetic Foot Wounds. Plastic and Reconstructive Surgery - Global Open, 5(4), e1302.
Hilmy, N., Yusof, N., & Nather, A. A. (Eds.). (2017). Human amniotic membrane: basic science and clinical application. World Scientific.
Hortensius, R. A., Ebens, J. H., & Harley, B. A. C. (2016). Immunomodulatory effects of amniotic membrane matrix incorporated into collagen scaffolds. Journal of Biomedical Materials Research Part A, 104(6), 1332–1342.
Kang, N. H., Hwang, K. A., Kim, S. U., Kim, Y. B., Hyun, S. H., Jeung, E. B., & Choi, K. C. (2012). Potential antitumor therapeutic strategies of human amniotic membrane and amniotic fluid-derived stem cells. Cancer Gene Therapy, 19(8), 517–522.
Lari, A. R., Alaghehbandan, R., & Akhlaghi, L. (2005). Burn wound infections and antimicrobial resistance in Tehran, Iran: an increasing problem. Annals of burns and fire disasters, 18(2), 68. (Lari et al., 2005)
Maan, Z. N., Rennert, R. C., Koob, T. J., Januszyk, M., Li, W. W., & Gurtner, G. C. (2015). Cell recruitment by amnion chorion grafts promotes neovascularization. Journal of Surgical Research, 193(2), 953–962.
Malhotra, C., & Jain, A. K. (2014). Human amniotic membrane transplantation: Different modalities of its use in ophthalmology. World Journal of Transplantation, 4(2), 111.
Mamede, A. C., Carvalho, M. J., Abrantes, A. M., Laranjo, M., Maia, C. J., & Botelho, M. F. (2012). Amniotic membrane: from structure and functions to clinical applications. Cell and Tissue Research, 349(2), 447–458.
Mohammadi, A. A., Bakhshaeekia, A., Alibeigi, P., Hasheminasab, M. J., Tolide-ei, H. R., Tavakkolian, A. R., & Mohammadi, M. K. (2009). Efficacy of Propranolol in Wound Healing for Hospitalized Burn Patients. Journal of Burn Care & Research, PAP.
Mohan, R., Bajaj, A., & Gundappa, M. (2017). Human amnion membrane: Potential applications in oral and periodontal field. Journal of International Society of Preventive and Community Dentistry, 7(1), 15.
Navas, A., Magaña-Guerrero, F. S., Domínguez-López, A., Chávez-García, C., Partido, G., Graue-Hernández, E. O., Sánchez-García, F. J., & Garfias, Y. (2018). Anti-Inflammatory and Anti-Fibrotic Effects of Human Amniotic Membrane Mesenchymal Stem Cells and Their Potential in Corneal Repair. Stem Cells Translational Medicine, 7(12), 906–917.
Omran, E., Hieneedy, H., Halwagy, A., Al-Inany, H., Al-Ansary, M., & Gad, A. (2016). Amniotic membrane can be a valid source for wound healing. International Journal of Women’s Health, Volume 8, 225–231.
Peterka, M., Peterková, R., & Likovský, Z. (2007). Chernobyl: Relationship between the Number of Missing Newborn Boys and the Level of Radiation in the Czech Regions. Environmental Health Perspectives, 115(12), 1801–1806.
Rahman, S., & Parvin, R. (2014). Therapeutic potential of Aegle marmelos (L.)-An overview. Asian Pacific Journal of Tropical Disease, 4(1), 71–77.
Robson, M. C., & krizek, T. J. (1973). The Effect of Human Amniotic Membranes on the Bacterial Population of Infected Rat Burns. Annals of Surgery, 177(2), 144–149.
Sheridan, R. L., & Thompkins, R. G. (2007). Alternative wound coverings. Total Burn Care, 239-245.
Singer, A. J., & Boyce, S. T. (2017). Burn Wound Healing and Tissue Engineering. Journal of Burn Care & Research, 38(3), e605–e613.
Ullah, M. S., Ferdous, K., Mullick, M. M. H., Alam, M. R., Rahman, M. S., & Khan, A. (2015). Amnion Membrane Graft Dressing in Superficial Partial Thickness Burn in Pediatric Patients. Chattagram Maa-O-Shishu Hospital Medical College Journal, 14(1), 22–25.
Weinhandl, E. D., Gilbertson, D. T., & Collins, A. J. (2016). Mortality, Hospitalization, and Technique Failure in Daily Home Hemodialysis and Matched Peritoneal Dialysis Patients: A Matched Cohort Study. American Journal of Kidney Diseases, 67(1), 98–110.
Zelen, C. M., Serena, T. E., Denoziere, G., & Fetterolf, D. E. (2013). A prospective randomised comparative parallel study of amniotic membrane wound graft in the management of diabetic foot ulcers. International Wound Journal, 10(5), 502–507.
Zhang, L., Zou, D., Li, S., Wang, J., Qu, Y., Ou, S., Jia, C., Li, J., He, H., Liu, T., Yang, J., Chen, Y., Liu, Z., & Li, W. (2016). An Ultra-thin Amniotic Membrane as Carrier in Corneal Epithelium Tissue-Engineering. Scientific Reports, 6(1).